STRINGSTRING
EME1 EME1 syf2 syf2 LOC100555945 LOC100555945 GPNMB GPNMB CCDC84 CCDC84 MSH2 MSH2 MRE11 MRE11 BLM BLM GAS1 GAS1 BRD7 BRD7 WAPL WAPL bub1b bub1b FBXO31 FBXO31 EIF2AK4 EIF2AK4 RINT1 RINT1 TAOK2 TAOK2 NUBP1 NUBP1 FBXO7 FBXO7 DACT1 DACT1 FOXO4 FOXO4 AVEN AVEN RPS6KA2 RPS6KA2 E2F8 E2F8 CDKN2D CDKN2D CCND1 CCND1 mrnip mrnip SPDL1 SPDL1 NEK2 NEK2 RBL2 RBL2 TIMELESS TIMELESS G1KSV5_ANOCA G1KSV5_ANOCA dot1l dot1l clspn clspn INIP INIP TTK TTK Tom1l1 Tom1l1 BUB3 BUB3 INHBA INHBA BCL2 BCL2 PRPF19 PRPF19 KAT2A KAT2A MOS MOS G1KUZ5_ANOCA G1KUZ5_ANOCA pttg1 pttg1 H9GQS0_ANOCA H9GQS0_ANOCA H9GQZ2_ANOCA H9GQZ2_ANOCA G1KVF2_ANOCA G1KVF2_ANOCA G1KVM7_ANOCA G1KVM7_ANOCA H9GRB7_ANOCA H9GRB7_ANOCA G1KVT4_ANOCA G1KVT4_ANOCA G1KWK2_ANOCA G1KWK2_ANOCA H9GSH6_ANOCA H9GSH6_ANOCA MTBP MTBP LOC100567301 LOC100567301 LOC100567826 LOC100567826 H9GTZ6_ANOCA H9GTZ6_ANOCA H9GU83_ANOCA H9GU83_ANOCA G1KY24_ANOCA G1KY24_ANOCA H9GUR8_ANOCA H9GUR8_ANOCA LOC103282695 LOC103282695 ATF5 ATF5 FBXO43 FBXO43 LOC103282543 LOC103282543 NABP2 NABP2 PIDD1 PIDD1 H9GVW7_ANOCA H9GVW7_ANOCA R4G943_ANOCA R4G943_ANOCA R4G9N3_ANOCA R4G9N3_ANOCA ENSACAP00000022017 ENSACAP00000022017 R4GA53_ANOCA R4GA53_ANOCA PINX1 PINX1 R4GAZ5_ANOCA R4GAZ5_ANOCA R4GCF9_ANOCA R4GCF9_ANOCA R4GCI0_ANOCA R4GCI0_ANOCA R4GCV3_ANOCA R4GCV3_ANOCA R4GDA8_ANOCA R4GDA8_ANOCA LOC103281644 LOC103281644 R4GDH7_ANOCA R4GDH7_ANOCA LOC103282748 LOC103282748 XPC XPC PSMG2 PSMG2 CDT1 CDT1 brca1 brca1 MAD2L1 MAD2L1 BUB1 BUB1 TAOK1 TAOK1 PKD2 PKD2 FOXN3 FOXN3 CTDSP2 CTDSP2 RBM14 RBM14 EEF1AKNMT EEF1AKNMT cacnb4 cacnb4 apbb1 apbb1 PLK1 PLK1 PRKDC PRKDC Apbb2 Apbb2 gpr132 gpr132 ERCC6 ERCC6 nop53 nop53 TRIM37 TRIM37 LOC103282856 LOC103282856 CDK1 CDK1 ABRAXAS1 ABRAXAS1 LOC100557521 LOC100557521 PPP1R10 PPP1R10 MAD1L1 MAD1L1 NBN NBN G1KJZ5_ANOCA G1KJZ5_ANOCA RAD17 RAD17 DNA2 DNA2 MAD2L1BP MAD2L1BP ZNF207 ZNF207 ZWILCH ZWILCH ZNF830 ZNF830 DCUN1D3 DCUN1D3 BABAM2 BABAM2 crlf3 crlf3 CEP63 CEP63 TRIP13 TRIP13 FHL1 FHL1 ZW10 ZW10 ATRIP ATRIP atrx atrx E2F1 E2F1 MFSD11 MFSD11 RAD1 RAD1 nme6 nme6 TICRR TICRR Cdc73 Cdc73 ORC1 ORC1 hus1 hus1 RAD9A RAD9A FANCD2 FANCD2 GTSE1 GTSE1 CHFR CHFR WAC WAC TPRA1 TPRA1 RBL1 RBL1 CASP2 CASP2 CDK5RAP3 CDK5RAP3 nabp1 nabp1 INTS7 INTS7 DTL DTL RFWD3 RFWD3 JADE1 JADE1 CDCA7 CDCA7 MAP3K20 MAP3K20 SDE2 SDE2 GPER1 GPER1 FBXO5 FBXO5 CTDSPL CTDSPL E2F7 E2F7 UIMC1 UIMC1 atm atm LOC103282074 LOC103282074 USP47 USP47 ATR ATR DONSON DONSON H9G988_ANOCA H9G988_ANOCA Kank2 Kank2 TAOK3 TAOK3 topbp1 topbp1 TIPIN TIPIN MDM1 MDM1 baz1b baz1b LOC103281294 LOC103281294 tmem67 tmem67 RB1 RB1 ZFYVE19 ZFYVE19 LOC100556408 LOC100556408 TNKS TNKS NAE1 NAE1 HINFP HINFP CDC6 CDC6 CTDSP1 CTDSP1 RAD9B RAD9B KNTC1 KNTC1 TPR TPR NEK11 NEK11 CCP110 CCP110 MACROH2A1 MACROH2A1 RGCC RGCC BRCC3 BRCC3 CHEK1 CHEK1 KAT2B KAT2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EME1Essential meiotic structure-specific endonuclease 1. (590 aa)
syf2Uncharacterized protein. (204 aa)
LOC100555945BTB domain-containing protein. (635 aa)
GPNMBGlycoprotein nmb. (573 aa)
CCDC84Coiled-coil domain containing 84. (354 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (953 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa)
BLMBLM RecQ like helicase. (1396 aa)
GAS1Growth arrest specific 1. (298 aa)
BRD7Bromodomain containing 7. (573 aa)
WAPLWAPL cohesin release factor. (1192 aa)
bub1bBUB1 N-terminal domain-containing protein. (1062 aa)
FBXO31F-box protein 31. (563 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1647 aa)
RINT1RAD50 interactor 1. (815 aa)
TAOK2TAO kinase 2. (1018 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (328 aa)
FBXO7F-box protein 7. (513 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (795 aa)
FOXO4Forkhead box O4. (539 aa)
AVENApoptosis and caspase activation inhibitor. (390 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
E2F8E2F transcription factor 8. (844 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (163 aa)
CCND1Cyclin D1. (154 aa)
mrnipUncharacterized protein. (120 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (629 aa)
NEK2NIMA related kinase 2. (446 aa)
RBL2RB transcriptional corepressor like 2. (1125 aa)
TIMELESSTimeless circadian regulator. (1204 aa)
G1KSV5_ANOCAANK_REP_REGION domain-containing protein. (1197 aa)
dot1lHistone-lysine N-methyltransferase, H3 lysine-79 specific. (139 aa)
clspnUncharacterized protein. (283 aa)
INIPINTS3 and NABP interacting protein. (124 aa)
TTKTTK protein kinase. (883 aa)
Tom1l1VHS domain-containing protein. (169 aa)
BUB3BUB3 mitotic checkpoint protein. (326 aa)
INHBAInhibin subunit beta A. (422 aa)
BCL2BCL2 apoptosis regulator. (170 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
KAT2ALysine acetyltransferase 2A. (853 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (350 aa)
G1KUZ5_ANOCAProtein kinase domain-containing protein. (429 aa)
pttg1Uncharacterized protein. (198 aa)
H9GQS0_ANOCACDC73_C domain-containing protein. (219 aa)
H9GQZ2_ANOCAUncharacterized protein. (166 aa)
G1KVF2_ANOCAPID domain-containing protein. (183 aa)
G1KVM7_ANOCAUncharacterized protein. (297 aa)
H9GRB7_ANOCAUncharacterized protein. (301 aa)
G1KVT4_ANOCAReverse transcriptase domain-containing protein. (399 aa)
G1KWK2_ANOCAReverse transcriptase domain-containing protein. (294 aa)
H9GSH6_ANOCAUncharacterized protein. (248 aa)
MTBPMDM2 binding protein. (922 aa)
LOC100567301Fibronectin type-III domain-containing protein. (250 aa)
LOC100567826Uncharacterized protein. (730 aa)
H9GTZ6_ANOCAUncharacterized protein. (621 aa)
H9GU83_ANOCAUncharacterized protein. (145 aa)
G1KY24_ANOCAReverse transcriptase domain-containing protein. (317 aa)
H9GUR8_ANOCASEA domain-containing protein. (648 aa)
LOC103282695SOSS complex subunit B2. (111 aa)
ATF5Activating transcription factor 5. (274 aa)
FBXO43F-box protein 43. (693 aa)
LOC103282543Uncharacterized protein. (158 aa)
NABP2Nucleic acid binding protein 2. (215 aa)
PIDD1P53-induced death domain protein 1. (885 aa)
H9GVW7_ANOCAReverse transcriptase domain-containing protein. (356 aa)
R4G943_ANOCAReverse transcriptase domain-containing protein. (305 aa)
R4G9N3_ANOCAReverse transcriptase domain-containing protein. (295 aa)
ENSACAP00000022017annotation not available (305 aa)
R4GA53_ANOCAUncharacterized protein. (146 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (344 aa)
R4GAZ5_ANOCAReverse transcriptase domain-containing protein. (767 aa)
R4GCF9_ANOCAReverse transcriptase domain-containing protein. (771 aa)
R4GCI0_ANOCAReverse transcriptase domain-containing protein. (300 aa)
R4GCV3_ANOCAReverse transcriptase domain-containing protein. (933 aa)
R4GDA8_ANOCAReverse transcriptase domain-containing protein. (1252 aa)
LOC103281644Uncharacterized protein. (459 aa)
R4GDH7_ANOCAUncharacterized protein. (271 aa)
LOC103282748Protein kinase domain-containing protein. (173 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (960 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (265 aa)
CDT1Chromatin licensing and DNA replication factor 1. (570 aa)
brca1Uncharacterized protein. (772 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1056 aa)
TAOK1TAO kinase 1. (1012 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (873 aa)
FOXN3Forkhead box N3. (495 aa)
CTDSP2CTD small phosphatase 2. (272 aa)
RBM14Uncharacterized protein. (607 aa)
EEF1AKNMTEEF1A lysine and N-terminal methyltransferase. (700 aa)
cacnb4SH3 domain-containing protein. (502 aa)
apbb1PID domain-containing protein. (125 aa)
PLK1Polo like kinase 1. (416 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4100 aa)
Apbb2WW domain-containing protein. (239 aa)
gpr132G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (296 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1440 aa)
nop53Uncharacterized protein. (294 aa)
TRIM37Tripartite motif containing 37. (967 aa)
LOC103282856Uncharacterized protein. (158 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (313 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (404 aa)
LOC100557521BTB domain-containing protein. (617 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (888 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (723 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (761 aa)
G1KJZ5_ANOCAUncharacterized protein. (266 aa)
RAD17RAD17 checkpoint clamp loader component. (678 aa)
DNA2DNA replication helicase/nuclease 2. (1065 aa)
MAD2L1BPMAD2L1 binding protein. (237 aa)
ZNF207Zinc finger protein 207. (315 aa)
ZWILCHZwilch kinetochore protein. (600 aa)
ZNF830Zinc finger protein 830. (376 aa)
DCUN1D3DCN1-like protein. (304 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
crlf3Fibronectin type-III domain-containing protein. (438 aa)
CEP63Centrosomal protein 63. (655 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
FHL1Four and a half LIM domains 1. (297 aa)
ZW10Zw10 kinetochore protein. (809 aa)
ATRIPATR interacting protein. (836 aa)
atrxUncharacterized protein. (2338 aa)
E2F1E2F transcription factor 1. (374 aa)
MFSD11Major facilitator superfamily domain containing 11. (396 aa)
RAD1RAD1 checkpoint DNA exonuclease. (216 aa)
nme6NDK domain-containing protein; Belongs to the NDK family. (188 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1882 aa)
Cdc73CDC73_N domain-containing protein. (289 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa)
FANCD2FA complementation group D2. (1450 aa)
GTSE1G2 and S-phase expressed 1. (719 aa)
CHFRCheckpoint with forkhead and ring finger domains. (676 aa)
WACWW domain containing adaptor with coiled-coil. (624 aa)
TPRA1Transmembrane protein adipocyte associated 1. (374 aa)
RBL1RB transcriptional corepressor like 1. (1052 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (446 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (512 aa)
nabp1OB domain-containing protein. (212 aa)
INTS7Integrator complex subunit 7. (966 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (709 aa)
RFWD3Ring finger and WD repeat domain 3. (701 aa)
JADE1Jade family PHD finger 1. (883 aa)
CDCA7Cell division cycle associated 7. (420 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (937 aa)
SDE2SDE2 telomere maintenance homolog. (362 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (347 aa)
FBXO5F-box protein 5. (389 aa)
CTDSPLCTD small phosphatase like. (258 aa)
E2F7E2F transcription factor 7. (875 aa)
UIMC1Ubiquitin interaction motif containing 1. (714 aa)
atmUncharacterized protein; Belongs to the PI3/PI4-kinase family. (423 aa)
LOC10328207453-BP1_Tudor domain-containing protein. (1012 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa)
DONSONDownstream neighbor of SON. (327 aa)
H9G988_ANOCAUncharacterized protein. (230 aa)
Kank2ANK_REP_REGION domain-containing protein. (89 aa)
TAOK3TAO kinase 3. (898 aa)
topbp1Uncharacterized protein. (946 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (246 aa)
MDM1Mdm1 nuclear protein. (729 aa)
baz1bWSD domain-containing protein. (105 aa)
LOC103281294Uncharacterized protein. (588 aa)
tmem67Uncharacterized protein. (983 aa)
RB1RB transcriptional corepressor 1. (901 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (397 aa)
LOC100556408FAT domain-containing protein. (2448 aa)
TNKSPoly [ADP-ribose] polymerase. (1286 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (575 aa)
HINFPHistone H4 transcription factor. (525 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (399 aa)
KNTC1Kinetochore associated 1. (2143 aa)
TPRTranslocated promoter region, nuclear basket protein. (2366 aa)
NEK11NIMA related kinase 11. (610 aa)
CCP110Centriolar coiled-coil protein 110. (985 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
RGCCRegulator of cell cycle. (114 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (261 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
KAT2BLysine acetyltransferase 2B. (617 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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