(54 nodes) Histone deacetylation network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (513 aa)
	RBM14	Uncharacterized protein. (607 aa)
	RCOR2	REST corepressor 2. (540 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	hdac9	HDAC4_Gln domain-containing protein. (590 aa)
	MIER2	MIER family member 2. (274 aa)
	G1KLU3_ANOCA	Hist_deacetyl domain-containing protein. (252 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	TBR1	T-box brain transcription factor 1. (412 aa)
	MIER1	MIER1 transcriptional regulator. (475 aa)
	HDAC11	Histone deacetylase 11. (337 aa)
	SIRT6	Sirtuin 6. (176 aa)
	SIRT1	Sirtuin 1. (634 aa)
	SIRT7	Sirtuin 7. (334 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (401 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1136 aa)
	LOC100564157	Prohibitin. (272 aa)
	GATAD2B	GATA zinc finger domain containing 2B. (594 aa)
	mbd2	Methyl-CpG binding domain protein 2. (270 aa)
	HDAC6	Histone deacetylase 6. (1204 aa)
	PHB	Prohibitin. (275 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1111 aa)
	SUDS3	SDS3 homolog, SIN3A corepressor complex component. (348 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	rbbp4	RB binding protein 4, chromatin remodeling factor. (435 aa)
	HOPX	HOP homeobox. (73 aa)
	SIN3B	SIN3 transcription regulator family member B. (598 aa)
	BRMS1L	BRMS1 like transcriptional repressor. (395 aa)
	MSL3	MSL complex subunit 3. (524 aa)
	TRERF1	Transcriptional regulating factor 1. (1151 aa)
	MTA2	Metastasis associated 1 family member 2. (700 aa)
	tbl1x	Uncharacterized protein. (531 aa)
	RCOR1	REST corepressor 1. (495 aa)
	SIN3A	SIN3 transcription regulator family member A. (1289 aa)
	G1KW90_ANOCA	Hist_deacetyl domain-containing protein. (173 aa)
	HDAC10	Histone deacetylase 10. (663 aa)
	RCOR3	REST corepressor 3. (580 aa)
	ELMSAN1	ELM2 and Myb/SANT domain containing 1. (1138 aa)
	Morf4l1	MRG domain-containing protein. (216 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (994 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (412 aa)
	MTA3	Metastasis associated 1 family member 3. (662 aa)
	LOC100558575	Mortality factor 4 like 1. (325 aa)
	ELK4	ETS transcription factor ELK4. (437 aa)
	EOMES	Eomesodermin. (477 aa)
	MTA1	Metastasis associated 1. (694 aa)
	SMARCAD1	Uncharacterized protein. (1024 aa)
	PRDM5	Zinc finger protein. (630 aa)
	LOC103281644	Uncharacterized protein. (459 aa)
	H9GU83_ANOCA	Uncharacterized protein. (145 aa)
	LOC103281850	Uncharacterized protein. (109 aa)
	H9GSZ4_ANOCA	MRG domain-containing protein. (210 aa)
	REST	RE1 silencing transcription factor. (897 aa)
	ZNF541	Zinc finger protein 541. (1324 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRMS1L	G1KLU3_ANOCA	ENSACAP00000001526	ENSACAP00000011824	BRMS1 like transcriptional repressor.	Hist_deacetyl domain-containing protein.	0.566
BRMS1L	G1KW90_ANOCA	ENSACAP00000001526	ENSACAP00000019154	BRMS1 like transcriptional repressor.	Hist_deacetyl domain-containing protein.	0.566
BRMS1L	GATAD2B	ENSACAP00000001526	ENSACAP00000008646	BRMS1 like transcriptional repressor.	GATA zinc finger domain containing 2B.	0.560
BRMS1L	H9GSZ4_ANOCA	ENSACAP00000001526	ENSACAP00000019762	BRMS1 like transcriptional repressor.	MRG domain-containing protein.	0.741
BRMS1L	HDAC1	ENSACAP00000001526	ENSACAP00000004062	BRMS1 like transcriptional repressor.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.831
BRMS1L	HDAC10	ENSACAP00000001526	ENSACAP00000019114	BRMS1 like transcriptional repressor.	Histone deacetylase 10.	0.566
BRMS1L	HDAC11	ENSACAP00000001526	ENSACAP00000011278	BRMS1 like transcriptional repressor.	Histone deacetylase 11.	0.566
BRMS1L	HDAC2	ENSACAP00000001526	ENSACAP00000012046	BRMS1 like transcriptional repressor.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.831
BRMS1L	HDAC3	ENSACAP00000001526	ENSACAP00000011701	BRMS1 like transcriptional repressor.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.747
BRMS1L	HDAC4	ENSACAP00000001526	ENSACAP00000009498	BRMS1 like transcriptional repressor.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.566
BRMS1L	HDAC5	ENSACAP00000001526	ENSACAP00000004435	BRMS1 like transcriptional repressor.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.566
BRMS1L	HDAC6	ENSACAP00000001526	ENSACAP00000007918	BRMS1 like transcriptional repressor.	Histone deacetylase 6.	0.566
BRMS1L	HDAC7	ENSACAP00000001526	ENSACAP00000015012	BRMS1 like transcriptional repressor.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.566
BRMS1L	LOC100558575	ENSACAP00000001526	ENSACAP00000014061	BRMS1 like transcriptional repressor.	Mortality factor 4 like 1.	0.741
BRMS1L	LOC103281850	ENSACAP00000001526	ENSACAP00000020215	BRMS1 like transcriptional repressor.	Uncharacterized protein.	0.754
BRMS1L	MSL3	ENSACAP00000001526	ENSACAP00000001400	BRMS1 like transcriptional repressor.	MSL complex subunit 3.	0.594
BRMS1L	MTA1	ENSACAP00000001526	ENSACAP00000013368	BRMS1 like transcriptional repressor.	Metastasis associated 1.	0.467
BRMS1L	MTA2	ENSACAP00000001526	ENSACAP00000000710	BRMS1 like transcriptional repressor.	Metastasis associated 1 family member 2.	0.467
BRMS1L	MTA3	ENSACAP00000001526	ENSACAP00000014395	BRMS1 like transcriptional repressor.	Metastasis associated 1 family member 3.	0.467
BRMS1L	Morf4l1	ENSACAP00000001526	ENSACAP00000015519	BRMS1 like transcriptional repressor.	MRG domain-containing protein.	0.741