(12 nodes) cAMP-mediated signaling network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATF1	Activating transcription factor 1. (280 aa)
	PDE7B	Phosphodiesterase. (423 aa)
	PDE7A	Phosphodiesterase. (485 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1604 aa)
	CREB1	cAMP responsive element binding protein 1. (349 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (172 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (505 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (435 aa)
	PDE2A	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (377 aa)
	GLP1R	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (490 aa)
	DGKQ	Diacylglycerol kinase. (910 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	PDE2A	ENSACAP00000007882	ENSACAP00000002806	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.706
ADCY1	PDE7A	ENSACAP00000007882	ENSACAP00000016486	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.706
ADCY1	PDE7B	ENSACAP00000007882	ENSACAP00000016812	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.706
ADCYAP1	ADCYAP1R1	ENSACAP00000008538	ENSACAP00000006216	Adenylate cyclase activating polypeptide 1.	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.998
ADCYAP1	GHRHR	ENSACAP00000008538	ENSACAP00000005977	Adenylate cyclase activating polypeptide 1.	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.	0.780
ADCYAP1	GLP1R	ENSACAP00000008538	ENSACAP00000001897	Adenylate cyclase activating polypeptide 1.	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.631
ADCYAP1R1	ADCYAP1	ENSACAP00000006216	ENSACAP00000008538	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1.	0.998
ATF1	CREB1	ENSACAP00000016946	ENSACAP00000009515	Activating transcription factor 1.	cAMP responsive element binding protein 1.	0.706
CREB1	ATF1	ENSACAP00000009515	ENSACAP00000016946	cAMP responsive element binding protein 1.	Activating transcription factor 1.	0.706
GHRHR	ADCYAP1	ENSACAP00000005977	ENSACAP00000008538	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1.	0.780
GLP1R	ADCYAP1	ENSACAP00000001897	ENSACAP00000008538	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1.	0.631
PDE2A	ADCY1	ENSACAP00000002806	ENSACAP00000007882	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.706
PDE7A	ADCY1	ENSACAP00000016486	ENSACAP00000007882	Phosphodiesterase.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.706
PDE7A	PDE7B	ENSACAP00000016486	ENSACAP00000016812	Phosphodiesterase.	Phosphodiesterase.	0.400
PDE7B	ADCY1	ENSACAP00000016812	ENSACAP00000007882	Phosphodiesterase.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.706
PDE7B	PDE7A	ENSACAP00000016812	ENSACAP00000016486	Phosphodiesterase.	Phosphodiesterase.	0.400