(16 nodes) Translesion synthesis network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (709 aa)
	PRIMPOL	Primase and DNA directed polymerase. (565 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	POLI	DNA polymerase iota. (521 aa)
	pclaf	PAF domain-containing protein. (72 aa)
	POLD1	DNA polymerase. (1113 aa)
	LOC100566348	Uncharacterized protein; Belongs to the AAA ATPase family. (890 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (708 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (807 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (473 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3091 aa)
	POLH	DNA polymerase eta. (689 aa)
	POLK	DNA polymerase kappa. (838 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1247 aa)
	SPRTN	SprT-like N-terminal domain. (487 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DTL	PCNA	ENSACAP00000006505	ENSACAP00000000398	Denticleless E3 ubiquitin protein ligase homolog.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.979
DTL	POLD1	ENSACAP00000006505	ENSACAP00000020141	Denticleless E3 ubiquitin protein ligase homolog.	DNA polymerase.	0.747
DTL	POLD2	ENSACAP00000006505	ENSACAP00000011545	Denticleless E3 ubiquitin protein ligase homolog.	DNA polymerase delta 2, accessory subunit.	0.714
DTL	POLE2	ENSACAP00000006505	ENSACAP00000000894	Denticleless E3 ubiquitin protein ligase homolog.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.778
DTL	REV3L	ENSACAP00000006505	ENSACAP00000011298	Denticleless E3 ubiquitin protein ligase homolog.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.562
DTL	pclaf	ENSACAP00000006505	ENSACAP00000022467	Denticleless E3 ubiquitin protein ligase homolog.	PAF domain-containing protein.	0.497
LOC100566348	PCNA	ENSACAP00000016727	ENSACAP00000000398	Uncharacterized protein; Belongs to the AAA ATPase family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.618
LOC100566348	POLH	ENSACAP00000016727	ENSACAP00000009824	Uncharacterized protein; Belongs to the AAA ATPase family.	DNA polymerase eta.	0.545
LOC100566348	POLI	ENSACAP00000016727	ENSACAP00000000212	Uncharacterized protein; Belongs to the AAA ATPase family.	DNA polymerase iota.	0.433
LOC100566348	SPRTN	ENSACAP00000016727	ENSACAP00000002751	Uncharacterized protein; Belongs to the AAA ATPase family.	SprT-like N-terminal domain.	0.805
LOC100566348	VCP	ENSACAP00000016727	ENSACAP00000011651	Uncharacterized protein; Belongs to the AAA ATPase family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.900
PCNA	DTL	ENSACAP00000000398	ENSACAP00000006505	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Denticleless E3 ubiquitin protein ligase homolog.	0.979
PCNA	LOC100566348	ENSACAP00000000398	ENSACAP00000016727	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.618
PCNA	POLD1	ENSACAP00000000398	ENSACAP00000020141	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase.	0.999
PCNA	POLD2	ENSACAP00000000398	ENSACAP00000011545	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase delta 2, accessory subunit.	0.999
PCNA	POLE2	ENSACAP00000000398	ENSACAP00000000894	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.799
PCNA	POLH	ENSACAP00000000398	ENSACAP00000009824	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase eta.	0.998
PCNA	POLI	ENSACAP00000000398	ENSACAP00000000212	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase iota.	0.978
PCNA	POLK	ENSACAP00000000398	ENSACAP00000008348	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase kappa.	0.978
PCNA	REV1	ENSACAP00000000398	ENSACAP00000008123	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.986