(13 nodes) Mismatched DNA binding network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TDG	Thymine DNA glycosylase. (405 aa)
	MLH3	MutL homolog 3. (1385 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (953 aa)
	mutyh	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (425 aa)
	MSH4	MutS homolog 4. (684 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1096 aa)
	MLH1	MutL homolog 1. (746 aa)
	msh5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (793 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (943 aa)
	APTX	Aprataxin. (359 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (846 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1317 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APTX	MSH3	ENSACAP00000003482	ENSACAP00000010450	Aprataxin.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.424
MLH1	MLH3	ENSACAP00000009935	ENSACAP00000016565	MutL homolog 1.	MutL homolog 3.	0.998
MLH1	MSH2	ENSACAP00000009935	ENSACAP00000013794	MutL homolog 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.999
MLH1	MSH3	ENSACAP00000009935	ENSACAP00000010450	MutL homolog 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.976
MLH1	MSH4	ENSACAP00000009935	ENSACAP00000010816	MutL homolog 1.	MutS homolog 4.	0.933
MLH1	MSH6	ENSACAP00000009935	ENSACAP00000013849	MutL homolog 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.997
MLH1	PCNA	ENSACAP00000009935	ENSACAP00000000398	MutL homolog 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.935
MLH1	PMS1	ENSACAP00000009935	ENSACAP00000004073	MutL homolog 1.	PMS1 homolog 1, mismatch repair system component.	0.993
MLH1	PMS2	ENSACAP00000009935	ENSACAP00000013064	MutL homolog 1.	PMS1 homolog 2, mismatch repair system component.	0.999
MLH1	msh5	ENSACAP00000009935	ENSACAP00000018995	MutL homolog 1.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.913
MLH1	mutyh	ENSACAP00000009935	ENSACAP00000014869	MutL homolog 1.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.614
MLH3	MLH1	ENSACAP00000016565	ENSACAP00000009935	MutL homolog 3.	MutL homolog 1.	0.998
MLH3	MSH2	ENSACAP00000016565	ENSACAP00000013794	MutL homolog 3.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.958
MLH3	MSH3	ENSACAP00000016565	ENSACAP00000010450	MutL homolog 3.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.941
MLH3	MSH4	ENSACAP00000016565	ENSACAP00000010816	MutL homolog 3.	MutS homolog 4.	0.928
MLH3	MSH6	ENSACAP00000016565	ENSACAP00000013849	MutL homolog 3.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.958
MLH3	PCNA	ENSACAP00000016565	ENSACAP00000000398	MutL homolog 3.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.800
MLH3	PMS1	ENSACAP00000016565	ENSACAP00000004073	MutL homolog 3.	PMS1 homolog 1, mismatch repair system component.	0.856
MLH3	PMS2	ENSACAP00000016565	ENSACAP00000013064	MutL homolog 3.	PMS1 homolog 2, mismatch repair system component.	0.863
MLH3	msh5	ENSACAP00000016565	ENSACAP00000018995	MutL homolog 3.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.927