50 items (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CFL1	Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1263 aa)
	MTMR9	Myotubularin related protein 9. (555 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1283 aa)
	EPS8L3	EPS8 like 3. (596 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (300 aa)
	CLASP2	Cytoplasmic linker associated protein 2. (791 aa)
	TIRAP	TIR domain containing adaptor protein. (215 aa)
	PSD	Pleckstrin and Sec7 domain containing. (946 aa)
	PSD3	Pleckstrin and Sec7 domain containing 3. (336 aa)
	RASGRP2	RAS guanyl releasing protein 2. (277 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (845 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (490 aa)
	PLA2G4F	Phospholipase A2. (865 aa)
	EPS8L2	EPS8 like 2. (736 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (661 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1041 aa)
	MTSS2	MTSS I-BAR domain containing 2. (765 aa)
	AIF1L	Allograft inflammatory factor 1 like. (152 aa)
	PLEK	Pleckstrin. (358 aa)
	ptprj	Uncharacterized protein. (1332 aa)
	PACSIN1	Protein kinase C and casein kinase substrate in neurons 1. (445 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1063 aa)
	PACSIN2	Protein kinase C and casein kinase substrate in neurons 2. (482 aa)
	aif1	EF-hand domain-containing protein. (119 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (383 aa)
	itgb3	Integrin beta; Belongs to the integrin beta chain family. (585 aa)
	EPS8L1	EPS8 like 1. (715 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1081 aa)
	LOC100558191	IPPc domain-containing protein. (202 aa)
	LOC103282689	IPPc domain-containing protein. (201 aa)
	LOC103281908	Phosphoinositide phospholipase C. (334 aa)
	plekho1	PH domain-containing protein. (84 aa)
	LOC100564889	EF-hand domain-containing protein. (93 aa)
	LOC100566976	Phosphoinositide phospholipase C. (889 aa)
	rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	PSD2	Pleckstrin and Sec7 domain containing 2. (707 aa)
	PDE9A	Phosphodiesterase. (539 aa)
	arhgap45	Rho GTPase activating protein 45. (981 aa)
	spata13	Uncharacterized protein. (1266 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (737 aa)
	LOC100556863	Myotubularin phosphatase domain-containing protein. (551 aa)
	EZR	Ezrin. (586 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1263 aa)
	LOC100563818	Uncharacterized protein. (423 aa)
	CIB3	Calcium and integrin binding family member 3. (135 aa)
	EPHA2	EPH receptor A2. (981 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (336 aa)
	JCAD	Junctional cadherin 5 associated. (1339 aa)
	CIB1	Uncharacterized protein. (85 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL2	PLEK	ENSACAP00000015408	ENSACAP00000000879	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Pleckstrin.	0.404
EPS8L3	MTSS2	ENSACAP00000011755	ENSACAP00000001702	EPS8 like 3.	MTSS I-BAR domain containing 2.	0.730
ITGAV	itgb3	ENSACAP00000001799	ENSACAP00000016529	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.999
LOC100566976	LOC103281908	ENSACAP00000001816	ENSACAP00000021510	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.934
LOC100566976	LOC103282689	ENSACAP00000001816	ENSACAP00000020935	Phosphoinositide phospholipase C.	IPPc domain-containing protein.	0.693
LOC100566976	PIP5K1A	ENSACAP00000001816	ENSACAP00000014648	Phosphoinositide phospholipase C.	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	0.706
LOC100566976	PLA2G4F	ENSACAP00000001816	ENSACAP00000014900	Phosphoinositide phospholipase C.	Phospholipase A2.	0.900
LOC100566976	PLCG1	ENSACAP00000001816	ENSACAP00000011188	Phosphoinositide phospholipase C.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.901
LOC100566976	PLCG2	ENSACAP00000001816	ENSACAP00000009223	Phosphoinositide phospholipase C.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.902
LOC103281908	LOC100566976	ENSACAP00000021510	ENSACAP00000001816	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.934
LOC103282689	LOC100566976	ENSACAP00000020935	ENSACAP00000001816	IPPc domain-containing protein.	Phosphoinositide phospholipase C.	0.693
LOC103282689	PLCG1	ENSACAP00000020935	ENSACAP00000011188	IPPc domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.693
LOC103282689	PLCG2	ENSACAP00000020935	ENSACAP00000009223	IPPc domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.693
MTSS2	EPS8L3	ENSACAP00000001702	ENSACAP00000011755	MTSS I-BAR domain containing 2.	EPS8 like 3.	0.730
PACSIN1	PACSIN2	ENSACAP00000015599	ENSACAP00000015756	Protein kinase C and casein kinase substrate in neurons 1.	Protein kinase C and casein kinase substrate in neurons 2.	0.872
PACSIN2	PACSIN1	ENSACAP00000015756	ENSACAP00000015599	Protein kinase C and casein kinase substrate in neurons 2.	Protein kinase C and casein kinase substrate in neurons 1.	0.872
PIP5K1A	LOC100566976	ENSACAP00000014648	ENSACAP00000001816	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	Phosphoinositide phospholipase C.	0.706
PIP5K1A	PLCG1	ENSACAP00000014648	ENSACAP00000011188	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.706
PIP5K1A	PLCG2	ENSACAP00000014648	ENSACAP00000009223	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.706
PLA2G4F	LOC100566976	ENSACAP00000014900	ENSACAP00000001816	Phospholipase A2.	Phosphoinositide phospholipase C.	0.900