(28 nodes) Tumor necrosis factor-mediated signaling pathway network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNFRSF19	TNF receptor superfamily member 19. (279 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (548 aa)
	PYCARD	PYD and CARD domain containing. (192 aa)
	TRAF2	TNF receptor-associated factor. (432 aa)
	ILK	Integrin linked kinase. (321 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
	commd7	COMM domain-containing protein. (127 aa)
	tnfrsf4	Uncharacterized protein. (206 aa)
	H9GGH2_ANOCA	MATH domain-containing protein. (185 aa)
	LOC100556341	Death domain-containing protein. (357 aa)
	G1KLA4_ANOCA	SEFIR domain-containing protein. (540 aa)
	krt8	IF rod domain-containing protein; Belongs to the intermediate filament family. (483 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (679 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (761 aa)
	EDA2R	Ectodysplasin A2 receptor. (241 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (253 aa)
	CARD14	Caspase recruitment domain family member 14. (987 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	LOC100566904	MATH domain-containing protein. (307 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1062 aa)
	LOC100561101	TNF_2 domain-containing protein. (234 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (657 aa)
	LOC103282543	Uncharacterized protein. (158 aa)
	LOC103278072	TNF_2 domain-containing protein. (239 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (621 aa)
	nfkbia	ANK_REP_REGION domain-containing protein. (310 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
	RELT	RELT TNF receptor. (219 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	H9GGH2_ANOCA	ENSACAP00000011973	ENSACAP00000010321	Component of inhibitor of nuclear factor kappa B kinase complex.	MATH domain-containing protein.	0.714
CHUK	IKBKB	ENSACAP00000011973	ENSACAP00000012680	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	LOC100556341	ENSACAP00000011973	ENSACAP00000011266	Component of inhibitor of nuclear factor kappa B kinase complex.	Death domain-containing protein.	0.869
CHUK	LOC100566904	ENSACAP00000011973	ENSACAP00000017068	Component of inhibitor of nuclear factor kappa B kinase complex.	MATH domain-containing protein.	0.520
CHUK	LOC103282543	ENSACAP00000011973	ENSACAP00000021196	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.489
CHUK	TRAF2	ENSACAP00000011973	ENSACAP00000006987	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.714
CHUK	TRAF3	ENSACAP00000011973	ENSACAP00000000193	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.805
CHUK	TRAF5	ENSACAP00000011973	ENSACAP00000016112	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.579
CHUK	TRAF6	ENSACAP00000011973	ENSACAP00000005007	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.990
CHUK	nfkbia	ENSACAP00000011973	ENSACAP00000001779	Component of inhibitor of nuclear factor kappa B kinase complex.	ANK_REP_REGION domain-containing protein.	0.999
EDA2R	TRAF3	ENSACAP00000013536	ENSACAP00000000193	Ectodysplasin A2 receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.540
EDA2R	TRAF6	ENSACAP00000013536	ENSACAP00000005007	Ectodysplasin A2 receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.774
G1KLA4_ANOCA	H9GGH2_ANOCA	ENSACAP00000011372	ENSACAP00000010321	SEFIR domain-containing protein.	MATH domain-containing protein.	0.413
G1KLA4_ANOCA	IKBKB	ENSACAP00000011372	ENSACAP00000012680	SEFIR domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.477
G1KLA4_ANOCA	TRAF2	ENSACAP00000011372	ENSACAP00000006987	SEFIR domain-containing protein.	TNF receptor-associated factor.	0.413
G1KLA4_ANOCA	TRAF3	ENSACAP00000011372	ENSACAP00000000193	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.742
G1KLA4_ANOCA	TRAF5	ENSACAP00000011372	ENSACAP00000016112	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.590
G1KLA4_ANOCA	TRAF6	ENSACAP00000011372	ENSACAP00000005007	SEFIR domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.886
H9GGH2_ANOCA	CHUK	ENSACAP00000010321	ENSACAP00000011973	MATH domain-containing protein.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.714
H9GGH2_ANOCA	G1KLA4_ANOCA	ENSACAP00000010321	ENSACAP00000011372	MATH domain-containing protein.	SEFIR domain-containing protein.	0.413