(133 nodes) Protein localization to nucleus network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TPR	Translocated promoter region, nuclear basket protein. (2366 aa)
	H9GEJ9_ANOCA	Uncharacterized protein. (199 aa)
	H9GEL4_ANOCA	Ras-GAP domain-containing protein. (53 aa)
	TSC2	TSC complex subunit 2. (1291 aa)
	RAN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (217 aa)
	FAM53C	Family with sequence similarity 53 member C. (365 aa)
	CIZ1	Matrin-type domain-containing protein. (708 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (863 aa)
	BBS4	Bardet-Biedl syndrome 4. (525 aa)
	ARL2BP	ADP ribosylation factor like GTPase 2 binding protein. (162 aa)
	KPNA1	Karyopherin subunit alpha 1. (652 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (651 aa)
	ING1	Inhibitor of growth protein. (280 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
	LOC100552827	SUN domain-containing protein. (338 aa)
	IPO9	Importin 9. (988 aa)
	RPL11	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
	RANGAP1	Ran GTPase activating protein 1. (591 aa)
	SHISA4	Shisa family member 4. (193 aa)
	KPNA6	Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
	H9G988_ANOCA	Uncharacterized protein. (230 aa)
	XPA	XPA, DNA damage recognition and repair factor. (280 aa)
	TAF3	TATA-box binding protein associated factor 3. (573 aa)
	NUP153	Nucleoporin 153. (1427 aa)
	NUP107	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (1052 aa)
	SNUPN	Snurportin 1. (174 aa)
	ipo4	Importin N-terminal domain-containing protein. (947 aa)
	TNPO2	Transportin 2. (888 aa)
	RRP7A	Ribosomal RNA processing 7 homolog A. (280 aa)
	arl2	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (161 aa)
	WRAP53	WD repeat containing antisense to TP53. (383 aa)
	WRN	WRN RecQ like helicase. (1315 aa)
	TAF8	TATA-box binding protein associated factor 8. (295 aa)
	E2F3	E2F transcription factor 3. (337 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (591 aa)
	LOC103280911	Uncharacterized protein. (237 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
	NOL8	Nucleolar protein 8. (1144 aa)
	H9GF05_ANOCA	BTB domain-containing protein. (390 aa)
	IPO7	Importin 7. (1038 aa)
	TNPO1	Transportin 1. (890 aa)
	SUPT7L	SPT7 like, STAGA complex gamma subunit. (251 aa)
	LOC100555044	Nucleoporin_N domain-containing protein. (631 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2125 aa)
	DCLK3	Doublecortin like kinase 3. (652 aa)
	MSX1	Msh homeobox 1. (281 aa)
	RPF2	Ribosome production factor 2 homolog. (309 aa)
	nop53	Uncharacterized protein. (294 aa)
	G1KLA4_ANOCA	SEFIR domain-containing protein. (540 aa)
	PLK1	Polo like kinase 1. (416 aa)
	INTS13	Integrator complex subunit 13. (755 aa)
	STK4	Serine/threonine kinase 4. (439 aa)
	NXT2	Nuclear transport factor 2 like export factor 2. (145 aa)
	morc3	CW-type domain-containing protein. (932 aa)
	NUP54	Nucleoporin 54. (512 aa)
	TMCO6	Transmembrane and coiled-coil domains 6. (536 aa)
	IPO8	Importin 8. (1042 aa)
	BANP	BTG3 associated nuclear protein. (443 aa)
	TNPO3	Transportin 3. (801 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	TOR1AIP1	Torsin 1A interacting protein 1. (504 aa)
	NUTF2	Nuclear transport factor 2. (137 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (344 aa)
	LOC103282085	Nup214_FG domain-containing protein. (450 aa)
	G1KZ35_ANOCA	Uncharacterized protein. (263 aa)
	H9GVG5_ANOCA	Uncharacterized protein. (136 aa)
	nup188	Uncharacterized protein. (516 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	LOC103282543	Uncharacterized protein. (158 aa)
	LOC103281782	Rap-GAP domain-containing protein. (312 aa)
	LOC103282979	Uncharacterized protein. (145 aa)
	H9GTP0_ANOCA	Nucleoporin_N domain-containing protein. (572 aa)
	RANGRF	RAN guanine nucleotide release factor. (195 aa)
	G1KWM2_ANOCA	LTD domain-containing protein. (509 aa)
	ABRA	Actin binding Rho activating protein. (392 aa)
	KPNA7	Karyopherin subunit alpha 7. (322 aa)
	H9GQI4_ANOCA	Nucleoporin_C domain-containing protein. (498 aa)
	STAT3	Signal transducer and activator of transcription. (773 aa)
	GLI3	GLI family zinc finger 3. (1489 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1588 aa)
	lmna	Lamin A/C; Belongs to the intermediate filament family. (604 aa)
	GPN2	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (307 aa)
	ipo5	Importin N-terminal domain-containing protein. (1111 aa)
	STK3	Serine/threonine kinase 3. (493 aa)
	GPN3	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (284 aa)
	CSE1L	Chromosome segregation 1 like. (971 aa)
	PLRG1	Pleiotropic regulator 1. (516 aa)
	NUP50	Nucleoporin 50. (515 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (661 aa)
	BARD1	BRCA1 associated RING domain 1. (769 aa)
	NUP88	Nucleoporin 88. (262 aa)
	MSX2	Msh homeobox 2. (269 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (363 aa)
	AKIRIN2	Akirin 2. (195 aa)
	CRY2	Cryptochrome circadian regulator 2. (586 aa)
	NUAK2	NUAK family kinase 2. (633 aa)
	FAM53B	Family with sequence similarity 53 member B. (419 aa)
	rpain	RPA_interact_C domain-containing protein. (116 aa)
	IPO13	Importin 13. (959 aa)
	NUP62	Nucleoporin 62. (599 aa)
	KPNA5	Importin subunit alpha; Belongs to the importin alpha family. (539 aa)
	RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1. (607 aa)
	NUP98	Nucleoporin 98. (1201 aa)
	LOC107982271	Uncharacterized protein. (178 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (447 aa)
	KPNA3	Importin subunit alpha; Belongs to the importin alpha family. (566 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2404 aa)
	HEATR3	HEAT repeat containing 3. (681 aa)
	XPO1	Exportin 1. (1071 aa)
	HIKESHI	Heat shock protein nuclear import factor hikeshi. (197 aa)
	RANBP2	RAN binding protein 2. (2819 aa)
	nfkbia	ANK_REP_REGION domain-containing protein. (310 aa)
	NUP35	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (327 aa)
	LOC100560393	Uncharacterized protein. (598 aa)
	Cnep1r1	Uncharacterized protein. (120 aa)
	UTP25	UTP25 small subunit processor component. (767 aa)
	txnip	Arrestin_N domain-containing protein. (124 aa)
	TOR1AIP2	Torsin 1A interacting protein 2. (280 aa)
	LOC100562919	LTD domain-containing protein. (246 aa)
	KPNA2	Importin subunit alpha; Belongs to the importin alpha family. (529 aa)
	SYK	Tyrosine-protein kinase. (634 aa)
	sun1	Uncharacterized protein. (798 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1. (245 aa)
	NUP133	Nucleoporin 133. (1144 aa)
	pola2	DNA_pol_E_B domain-containing protein. (184 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	KPNA4	Importin subunit alpha; Belongs to the importin alpha family. (504 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (748 aa)
	LOC100563058	Uncharacterized protein. (397 aa)
	SUN2	Sad1 and UNC84 domain containing 2. (716 aa)
	LRRK2	Leucine rich repeat kinase 2. (2540 aa)
	PTTG1IP	PTTG1 interacting protein. (176 aa)
	IPO11	Importin 11. (978 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKIRIN2	RAN	ENSACAP00000014566	ENSACAP00000007043	Akirin 2.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.466
APPL1	APPL2	ENSACAP00000005582	ENSACAP00000015408	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.994
APPL2	APPL1	ENSACAP00000015408	ENSACAP00000005582	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.994
ARL2BP	arl2	ENSACAP00000006607	ENSACAP00000003439	ADP ribosylation factor like GTPase 2 binding protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.986
BANP	LOC103282543	ENSACAP00000013256	ENSACAP00000021196	BTG3 associated nuclear protein.	Uncharacterized protein.	0.768
BARD1	LOC103282543	ENSACAP00000015187	ENSACAP00000021196	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.827
BARD1	PLK1	ENSACAP00000015187	ENSACAP00000011896	BRCA1 associated RING domain 1.	Polo like kinase 1.	0.478
BARD1	WRN	ENSACAP00000015187	ENSACAP00000003095	BRCA1 associated RING domain 1.	WRN RecQ like helicase.	0.989
BBS4	INTS13	ENSACAP00000006722	ENSACAP00000011980	Bardet-Biedl syndrome 4.	Integrator complex subunit 13.	0.455
BBS4	SMO	ENSACAP00000006722	ENSACAP00000023331	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.625
CIZ1	NUTF2	ENSACAP00000006836	ENSACAP00000022464	Matrin-type domain-containing protein.	Nuclear transport factor 2.	0.405
CSE1L	G1KZ35_ANOCA	ENSACAP00000015734	ENSACAP00000021381	Chromosome segregation 1 like.	Uncharacterized protein.	0.636
CSE1L	H9GVG5_ANOCA	ENSACAP00000015734	ENSACAP00000021327	Chromosome segregation 1 like.	Uncharacterized protein.	0.539
CSE1L	IPO13	ENSACAP00000015734	ENSACAP00000014031	Chromosome segregation 1 like.	Importin 13.	0.568
CSE1L	IPO9	ENSACAP00000015734	ENSACAP00000005187	Chromosome segregation 1 like.	Importin 9.	0.441
CSE1L	KPNA1	ENSACAP00000015734	ENSACAP00000006427	Chromosome segregation 1 like.	Karyopherin subunit alpha 1.	0.969
CSE1L	KPNA2	ENSACAP00000015734	ENSACAP00000000380	Chromosome segregation 1 like.	Importin subunit alpha; Belongs to the importin alpha family.	0.645
CSE1L	KPNA3	ENSACAP00000015734	ENSACAP00000013697	Chromosome segregation 1 like.	Importin subunit alpha; Belongs to the importin alpha family.	0.963
CSE1L	KPNA4	ENSACAP00000015734	ENSACAP00000007158	Chromosome segregation 1 like.	Importin subunit alpha; Belongs to the importin alpha family.	0.962
CSE1L	KPNA5	ENSACAP00000015734	ENSACAP00000013881	Chromosome segregation 1 like.	Importin subunit alpha; Belongs to the importin alpha family.	0.636