(62 nodes) Cellular response to reactive oxygen species network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NET1	Neuroepithelial cell transforming 1. (622 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	H9GK66_ANOCA	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (83 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (662 aa)
	SIRT1	Sirtuin 1. (634 aa)
	PTPRK	Protein tyrosine phosphatase receptor type K. (1479 aa)
	H9GGQ9_ANOCA	Uncharacterized protein. (95 aa)
	pjvk	Gasdermin domain-containing protein. (354 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	LOC103282606	Protein kinase domain-containing protein. (316 aa)
	G1KUA1_ANOCA	NDK domain-containing protein; Belongs to the NDK family. (119 aa)
	CCS	Copper chaperone for superoxide dismutase. (276 aa)
	NCF1	Neutrophil cytosolic factor 1. (195 aa)
	G1KV53_ANOCA	Uncharacterized protein. (107 aa)
	EDN1	Endothelin 1. (209 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1042 aa)
	ECT2	Epithelial cell transforming 2. (979 aa)
	LOC100564467	Catalase domain-containing protein. (365 aa)
	IL6	Interleukin 6. (211 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1188 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	PRDX1	Peroxiredoxin 1. (199 aa)
	LOC100563825	BZIP domain-containing protein. (341 aa)
	ANXA1	Annexin. (342 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	H9GJN5_ANOCA	Catalase domain-containing protein. (348 aa)
	FANCC	FA complementation group C. (562 aa)
	ANKZF1	Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (706 aa)
	LOC100566382	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	H9GUF0_ANOCA	Protein kinase domain-containing protein. (347 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1415 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (699 aa)
	H9GK92_ANOCA	Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
	setx	Uncharacterized protein. (1781 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (392 aa)
	TNFAIP3	TNF alpha induced protein 3. (829 aa)
	LOC100557620	Uncharacterized protein. (253 aa)
	LOC103282369	PG_binding_1 domain-containing protein. (128 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (241 aa)
	FXN	Frataxin. (157 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	IMPACT	Impact RWD domain protein. (318 aa)
	rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (137 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	OSER1	Oxidative stress responsive serine rich 1. (280 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	AXL	AXL receptor tyrosine kinase. (879 aa)
	sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
	KDM6B	Lysine demethylase 6B. (1380 aa)
	aqp1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (256 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (227 aa)
	prdx5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (206 aa)
	ROMO1	Reactive oxygen species modulator 1. (79 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)
	rnf112	Uncharacterized protein. (609 aa)
	ZNF277	Zinc finger protein 277. (481 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (801 aa)
	LOC100561291	Uncharacterized protein; Belongs to the cytochrome P450 family. (343 aa)
	FABP1	Fatty acid binding protein 1. (134 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	prdx5	ENSACAP00000008812	ENSACAP00000006272	Apoptosis inducing factor mitochondria associated 1.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.450
AIFM1	sod2	ENSACAP00000008812	ENSACAP00000004416	Apoptosis inducing factor mitochondria associated 1.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.681
ANXA1	SOD1	ENSACAP00000011838	ENSACAP00000002450	Annexin.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.424
ANXA1	SOD3	ENSACAP00000011838	ENSACAP00000000349	Annexin.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.424
CCS	FXN	ENSACAP00000019407	ENSACAP00000001162	Copper chaperone for superoxide dismutase.	Frataxin.	0.455
CCS	G1KUA1_ANOCA	ENSACAP00000019407	ENSACAP00000017404	Copper chaperone for superoxide dismutase.	NDK domain-containing protein; Belongs to the NDK family.	0.475
CCS	SOD1	ENSACAP00000019407	ENSACAP00000002450	Copper chaperone for superoxide dismutase.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.969
CCS	SOD3	ENSACAP00000019407	ENSACAP00000000349	Copper chaperone for superoxide dismutase.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.972
CCS	sod2	ENSACAP00000019407	ENSACAP00000004416	Copper chaperone for superoxide dismutase.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.689
EDN1	IL6	ENSACAP00000008302	ENSACAP00000023010	Endothelin 1.	Interleukin 6.	0.435
FOS	IL6	ENSACAP00000016663	ENSACAP00000023010	Fos proto-oncogene, AP-1 transcription factor subunit.	Interleukin 6.	0.557
FOS	JUN	ENSACAP00000016663	ENSACAP00000006894	Fos proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.992
FOS	KDM6B	ENSACAP00000016663	ENSACAP00000004438	Fos proto-oncogene, AP-1 transcription factor subunit.	Lysine demethylase 6B.	0.420
FOS	LOC100563825	ENSACAP00000016663	ENSACAP00000021890	Fos proto-oncogene, AP-1 transcription factor subunit.	BZIP domain-containing protein.	0.981
FOS	MAPK1	ENSACAP00000016663	ENSACAP00000001346	Fos proto-oncogene, AP-1 transcription factor subunit.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.720
FOS	MAPK13	ENSACAP00000016663	ENSACAP00000016684	Fos proto-oncogene, AP-1 transcription factor subunit.	Mitogen-activated protein kinase.	0.525
FOS	MAPK3	ENSACAP00000016663	ENSACAP00000014825	Fos proto-oncogene, AP-1 transcription factor subunit.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.720
FOS	MAPK7	ENSACAP00000016663	ENSACAP00000007626	Fos proto-oncogene, AP-1 transcription factor subunit.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.720
FOS	MAPK9	ENSACAP00000016663	ENSACAP00000016450	Fos proto-oncogene, AP-1 transcription factor subunit.	Mitogen-activated protein kinase.	0.752
FXN	CCS	ENSACAP00000001162	ENSACAP00000019407	Frataxin.	Copper chaperone for superoxide dismutase.	0.455