(27 nodes) Interstrand cross-link repair network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FANCD2	FA complementation group D2. (1450 aa)
	FAAP24	FA core complex associated protein 24. (211 aa)
	RFWD3	Ring finger and WD repeat domain 3. (701 aa)
	XPA	XPA, DNA damage recognition and repair factor. (280 aa)
	FANCM	FA complementation group M. (1855 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1019 aa)
	ercc1	Uncharacterized protein. (297 aa)
	cenpx	Uncharacterized protein. (83 aa)
	HROB	Chromosome 17 open reading frame 53. (613 aa)
	LOC100566348	Uncharacterized protein; Belongs to the AAA ATPase family. (890 aa)
	FANCF	FA complementation group F. (313 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	FANCC	FA complementation group C. (562 aa)
	Slx4	Uncharacterized protein. (81 aa)
	NUCKS1	Nuclear casein kinase and cyclin dependent kinase substrate 1. (294 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (807 aa)
	FANCB	FA complementation group B. (836 aa)
	LOC103282244	Fanconi_A_N domain-containing protein. (162 aa)
	LOC103281772	Uncharacterized protein. (284 aa)
	FANCL	FA complementation group L. (420 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (842 aa)
	DCLRE1B	DNA cross-link repair 1B. (309 aa)
	DCLRE1C	DNA cross-link repair 1C. (592 aa)
	FANCG	FA complementation group G. (648 aa)
	NEIL3	Nei like DNA glycosylase 3. (415 aa)
	H9GT41_ANOCA	Uncharacterized protein. (189 aa)
	DCLRE1A	DNA cross-link repair 1A. (998 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCLRE1A	DCLRE1B	ENSACAP00000020222	ENSACAP00000002186	DNA cross-link repair 1A.	DNA cross-link repair 1B.	0.487
DCLRE1A	ERCC4	ENSACAP00000020222	ENSACAP00000003517	DNA cross-link repair 1A.	ERCC excision repair 4, endonuclease catalytic subunit.	0.617
DCLRE1A	FAAP24	ENSACAP00000020222	ENSACAP00000007106	DNA cross-link repair 1A.	FA core complex associated protein 24.	0.657
DCLRE1A	FAN1	ENSACAP00000020222	ENSACAP00000021554	DNA cross-link repair 1A.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.732
DCLRE1A	FANCB	ENSACAP00000020222	ENSACAP00000010423	DNA cross-link repair 1A.	FA complementation group B.	0.484
DCLRE1A	FANCC	ENSACAP00000020222	ENSACAP00000012952	DNA cross-link repair 1A.	FA complementation group C.	0.571
DCLRE1A	FANCD2	ENSACAP00000020222	ENSACAP00000007782	DNA cross-link repair 1A.	FA complementation group D2.	0.761
DCLRE1A	FANCF	ENSACAP00000020222	ENSACAP00000014846	DNA cross-link repair 1A.	FA complementation group F.	0.542
DCLRE1A	FANCG	ENSACAP00000020222	ENSACAP00000023434	DNA cross-link repair 1A.	FA complementation group G.	0.473
DCLRE1A	FANCL	ENSACAP00000020222	ENSACAP00000003965	DNA cross-link repair 1A.	FA complementation group L.	0.603
DCLRE1A	FANCM	ENSACAP00000020222	ENSACAP00000004068	DNA cross-link repair 1A.	FA complementation group M.	0.821
DCLRE1A	H9GT41_ANOCA	ENSACAP00000020222	ENSACAP00000019842	DNA cross-link repair 1A.	Uncharacterized protein.	0.628
DCLRE1A	LOC103281772	ENSACAP00000020222	ENSACAP00000007958	DNA cross-link repair 1A.	Uncharacterized protein.	0.590
DCLRE1A	LOC103282244	ENSACAP00000020222	ENSACAP00000009161	DNA cross-link repair 1A.	Fanconi_A_N domain-containing protein.	0.590
DCLRE1A	RAD51	ENSACAP00000020222	ENSACAP00000013598	DNA cross-link repair 1A.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.407
DCLRE1A	Slx4	ENSACAP00000020222	ENSACAP00000012435	DNA cross-link repair 1A.	Uncharacterized protein.	0.714
DCLRE1A	XPA	ENSACAP00000020222	ENSACAP00000004266	DNA cross-link repair 1A.	XPA, DNA damage recognition and repair factor.	0.496
DCLRE1A	ercc1	ENSACAP00000020222	ENSACAP00000023179	DNA cross-link repair 1A.	Uncharacterized protein.	0.628
DCLRE1B	DCLRE1A	ENSACAP00000002186	ENSACAP00000020222	DNA cross-link repair 1B.	DNA cross-link repair 1A.	0.487
DCLRE1B	ERCC4	ENSACAP00000002186	ENSACAP00000003517	DNA cross-link repair 1B.	ERCC excision repair 4, endonuclease catalytic subunit.	0.617