(65 nodes) Digestive tract development network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100552212	PIP49_C domain-containing protein. (307 aa)
	G1KPC1_ANOCA	Uncharacterized protein. (59 aa)
	SAV1	Salvador family WW domain containing protein 1. (367 aa)
	LOC100566319	Uncharacterized protein. (254 aa)
	IL6ST	Interleukin 6 signal transducer. (912 aa)
	LOC100568056	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (438 aa)
	SFRP2	Secreted frizzled related protein 2. (309 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (957 aa)
	CCDC40	Coiled-coil domain containing 40. (881 aa)
	ednrb	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (399 aa)
	H9GN89_ANOCA	Fork-head domain-containing protein. (101 aa)
	PDGFC	Platelet derived growth factor C. (340 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (435 aa)
	MYOCD	Myocardin. (956 aa)
	GLI3	GLI family zinc finger 3. (1489 aa)
	BCL2	BCL2 apoptosis regulator. (170 aa)
	foxf2	Fork-head domain-containing protein. (360 aa)
	LOC103282640	Uncharacterized protein. (124 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	GATA4	GATA binding protein 4. (414 aa)
	HLX	H2.0 like homeobox. (328 aa)
	H9G6W7_ANOCA	Uncharacterized protein. (101 aa)
	VPS52	VPS52 subunit of GARP complex. (546 aa)
	pdx1	Homeobox domain-containing protein. (279 aa)
	CDX2	Caudal type homeobox 2. (119 aa)
	RB1	RB transcriptional corepressor 1. (901 aa)
	G1KC47_ANOCA	Homeobox domain-containing protein. (106 aa)
	KLF5	Kruppel like factor 5. (425 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (737 aa)
	LOC100564878	Uncharacterized protein; Belongs to the potassium channel family. (632 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CLMP	CXADR like membrane protein. (370 aa)
	GATA5	GATA binding protein 5. (399 aa)
	PRDM1	PR/SET domain 1. (770 aa)
	LOC100562908	Uncharacterized protein. (420 aa)
	HNF1B	HNF1 homeobox B. (465 aa)
	IFT172	Uncharacterized protein. (955 aa)
	Pkd1	Uncharacterized protein. (816 aa)
	CCDC103	Coiled-coil domain containing 103. (244 aa)
	GATA6	GATA binding protein 6. (562 aa)
	LOC100561101	TNF_2 domain-containing protein. (234 aa)
	Nkx3-1	Homeobox domain-containing protein. (62 aa)
	LOC103280514	SH3 domain-containing protein. (95 aa)
	LOC103282539	Uncharacterized protein. (227 aa)
	H9GVG2_ANOCA	Uncharacterized protein. (589 aa)
	FOXL1	Forkhead box L1. (322 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (707 aa)
	ID2	Inhibitor of DNA binding 2. (137 aa)
	LOC103278072	TNF_2 domain-containing protein. (239 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1398 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (294 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
	H9GEX9_ANOCA	Uncharacterized protein. (3670 aa)
	NIPBL	Nipped-B protein. (2777 aa)
	AHI1	Abelson helper integration site 1. (1243 aa)
	SMAD3	Mothers against decapentaplegic homolog. (383 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (946 aa)
	TCF21	Transcription factor 21. (178 aa)
	HOXA5	Homeobox A5. (305 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	RBPMS2	RNA binding protein, mRNA processing factor 2. (161 aa)
	C1GALT1	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (413 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CTNNB1	ENSACAP00000017311	ENSACAP00000004430	BCL2 apoptosis regulator.	Catenin beta 1.	0.457
CCDC103	CCDC40	ENSACAP00000007462	ENSACAP00000015696	Coiled-coil domain containing 103.	Coiled-coil domain containing 40.	0.557
CCDC103	DNAAF1	ENSACAP00000007462	ENSACAP00000012838	Coiled-coil domain containing 103.	Dynein assembly factor 1, axonemal.	0.569
CCDC40	CCDC103	ENSACAP00000015696	ENSACAP00000007462	Coiled-coil domain containing 40.	Coiled-coil domain containing 103.	0.557
CCDC40	DNAAF1	ENSACAP00000015696	ENSACAP00000012838	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.672
CDX2	GATA6	ENSACAP00000003220	ENSACAP00000007642	Caudal type homeobox 2.	GATA binding protein 6.	0.623
CLDN18	SMAD2	ENSACAP00000008977	ENSACAP00000017731	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Mothers against decapentaplegic homolog.	0.404
CLDN18	SMAD3	ENSACAP00000008977	ENSACAP00000009794	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Mothers against decapentaplegic homolog.	0.404
CTNNB1	BCL2	ENSACAP00000004430	ENSACAP00000017311	Catenin beta 1.	BCL2 apoptosis regulator.	0.457
CTNNB1	SFRP2	ENSACAP00000004430	ENSACAP00000015499	Catenin beta 1.	Secreted frizzled related protein 2.	0.556
CTNNB1	SMAD2	ENSACAP00000004430	ENSACAP00000017731	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.687
CTNNB1	SMAD3	ENSACAP00000004430	ENSACAP00000009794	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.687
CTNNB1	SMO	ENSACAP00000004430	ENSACAP00000023331	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.434
DNAAF1	CCDC103	ENSACAP00000012838	ENSACAP00000007462	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 103.	0.569
DNAAF1	CCDC40	ENSACAP00000012838	ENSACAP00000015696	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 40.	0.672
GATA4	H9GN89_ANOCA	ENSACAP00000001862	ENSACAP00000016168	GATA binding protein 4.	Fork-head domain-containing protein.	0.428
GATA4	foxf2	ENSACAP00000001862	ENSACAP00000017459	GATA binding protein 4.	Fork-head domain-containing protein.	0.428
GATA5	H9GN89_ANOCA	ENSACAP00000004962	ENSACAP00000016168	GATA binding protein 5.	Fork-head domain-containing protein.	0.428
GATA5	foxf2	ENSACAP00000004962	ENSACAP00000017459	GATA binding protein 5.	Fork-head domain-containing protein.	0.428
GATA6	CDX2	ENSACAP00000007642	ENSACAP00000003220	GATA binding protein 6.	Caudal type homeobox 2.	0.623