(69 nodes) Positive regulation of synaptic transmission network (Anolis carolinensis)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (396 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (308 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (684 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (964 aa)
	slc4a8	Anion exchange protein. (754 aa)
	NTRK2	Tyrosine-protein kinase receptor. (864 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	RAPSN	Receptor associated protein of the synapse. (420 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (980 aa)
	IGSF11	Immunoglobulin superfamily member 11. (404 aa)
	Nalcn	Uncharacterized protein. (729 aa)
	CLSTN2	Calsyntenin 2. (957 aa)
	DTNBP1	Dystrobrevin binding protein 1. (344 aa)
	H9G8K7_ANOCA	PDZ domain-containing protein. (101 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1607 aa)
	SNAP47	Synaptosome associated protein 47. (422 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (413 aa)
	RELN	Reelin. (3312 aa)
	NPTN	Neuroplastin. (402 aa)
	LGI1	Leucine rich glioma inactivated 1. (543 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (300 aa)
	Nps	Uncharacterized protein. (63 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (288 aa)
	CLSTN3	Calsyntenin 3. (973 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (445 aa)
	LRRTM1	Leucine rich repeat transmembrane neuronal 1. (522 aa)
	FMR1	Fragile X mental retardation 1. (618 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
	LGMN	Legumain. (438 aa)
	SLC1A3	Amino acid transporter. (543 aa)
	NFATC4	Nuclear factor of activated T cells 4. (839 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1404 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (289 aa)
	LAMA1	Laminin subunit alpha 1. (3149 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1500 aa)
	PRRT1	Proline rich transmembrane protein 1. (261 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1227 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (807 aa)
	CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5. (271 aa)
	stx1a	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (108 aa)
	slc4a8-2	Anion exchange protein. (1186 aa)
	TSHZ3	Teashirt zinc finger homeobox 3. (1080 aa)
	cacnb4	SH3 domain-containing protein. (502 aa)
	MECP2	Methyl-CpG binding protein 2. (517 aa)
	CLSTN1	Calsyntenin 1. (987 aa)
	SYT12	Synaptotagmin 12. (420 aa)
	Lama2	Uncharacterized protein. (1860 aa)
	STX2	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (287 aa)
	KCTD13	Potassium channel tetramerization domain containing 13. (337 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (312 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1647 aa)
	APP	Amyloid beta precursor protein. (776 aa)
	TNR	Tenascin R. (1360 aa)
	SHISA7	Shisa family member 7. (512 aa)
	LRRTM2	Leucine rich repeat transmembrane neuronal 2. (516 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1252 aa)
	CACNG7	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (281 aa)
	SLC24A2	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (643 aa)
	LOC100561101	TNF_2 domain-containing protein. (234 aa)
	G1KVE7_ANOCA	Uncharacterized protein. (619 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1184 aa)
	CACNG8	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (368 aa)
	NRGN	Neurogranin. (62 aa)
	AKAP5	A-kinase anchoring protein 5. (452 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1387 aa)
	LOC103278072	TNF_2 domain-containing protein. (239 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY8	ENSACAP00000007882	ENSACAP00000010472	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.955
ADCY8	ADCY1	ENSACAP00000010472	ENSACAP00000007882	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.955
ADCY8	GRIN2A	ENSACAP00000010472	ENSACAP00000000881	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.460
ADCY8	GRIN2B	ENSACAP00000010472	ENSACAP00000010352	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.400
APP	CLSTN1	ENSACAP00000014509	ENSACAP00000013063	Amyloid beta precursor protein.	Calsyntenin 1.	0.461
APP	FMR1	ENSACAP00000014509	ENSACAP00000007816	Amyloid beta precursor protein.	Fragile X mental retardation 1.	0.443
APP	GFAP	ENSACAP00000014509	ENSACAP00000007452	Amyloid beta precursor protein.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.522
APP	GRIN2A	ENSACAP00000014509	ENSACAP00000000881	Amyloid beta precursor protein.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.407
APP	GRIN2B	ENSACAP00000014509	ENSACAP00000010352	Amyloid beta precursor protein.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.474
APP	RELN	ENSACAP00000014509	ENSACAP00000006746	Amyloid beta precursor protein.	Reelin.	0.437
CACNG2	cacnb4	ENSACAP00000016014	ENSACAP00000012265	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	SH3 domain-containing protein.	0.454
CACNG4	CACNG5	ENSACAP00000000189	ENSACAP00000011119	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Calcium voltage-gated channel auxiliary subunit gamma 5.	0.540
CACNG4	CACNG7	ENSACAP00000000189	ENSACAP00000016275	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.540
CACNG4	GRIN2A	ENSACAP00000000189	ENSACAP00000000881	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.584
CACNG4	GRIN2B	ENSACAP00000000189	ENSACAP00000010352	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.576
CACNG4	GRIN2D	ENSACAP00000000189	ENSACAP00000016032	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor NMDA type subunit 2D.	0.557
CACNG4	SHISA7	ENSACAP00000000189	ENSACAP00000015739	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Shisa family member 7.	0.627
CACNG4	cacnb4	ENSACAP00000000189	ENSACAP00000012265	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	SH3 domain-containing protein.	0.635
CACNG5	CACNG4	ENSACAP00000011119	ENSACAP00000000189	Calcium voltage-gated channel auxiliary subunit gamma 5.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.540
CACNG5	CACNG7	ENSACAP00000011119	ENSACAP00000016275	Calcium voltage-gated channel auxiliary subunit gamma 5.	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.548