(76 nodes) Positive regulation of NF-kappaB transcription factor activity network (Anolis carolinensis)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (761 aa)
	LOC103278072	TNF_2 domain-containing protein. (239 aa)
	R4GBJ5_ANOCA	CTCK domain-containing protein. (244 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (657 aa)
	H9GUF0_ANOCA	Protein kinase domain-containing protein. (347 aa)
	TIRAP	TIR domain containing adaptor protein. (215 aa)
	TRADD	TNFRSF1A associated via death domain. (327 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (301 aa)
	LOC103279342	Uncharacterized protein. (553 aa)
	MALT1	MALT1 paracaspase. (731 aa)
	G1KVG4_ANOCA	CTCK domain-containing protein. (184 aa)
	LOC100561101	TNF_2 domain-containing protein. (234 aa)
	TRIM32	Tripartite motif containing 32. (653 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (699 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (479 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (383 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
	CARD14	Caspase recruitment domain family member 14. (987 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (766 aa)
	H9GM92_ANOCA	Uncharacterized protein. (170 aa)
	DHX33	DEAH-box helicase 33. (671 aa)
	NTRK1	Tyrosine-protein kinase receptor. (800 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (692 aa)
	APP	Amyloid beta precursor protein. (776 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	EDA2R	Ectodysplasin A2 receptor. (241 aa)
	CTH	Cystathionine gamma-lyase. (405 aa)
	LOC100566382	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	H9GJN5_ANOCA	Catalase domain-containing protein. (348 aa)
	RAB7B	RAB7B, member RAS oncogene family. (200 aa)
	TRIM62	Tripartite motif containing 62. (479 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (679 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (679 aa)
	MTPN	Myotrophin. (118 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (157 aa)
	H9GHU4_ANOCA	Uncharacterized protein. (267 aa)
	TRIM37	Tripartite motif containing 37. (967 aa)
	NTS	Neurotensin. (165 aa)
	H9GGH2_ANOCA	MATH domain-containing protein. (185 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (560 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (838 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
	ar	Androgen receptor. (232 aa)
	LOC103282606	Protein kinase domain-containing protein. (316 aa)
	CARD11	Caspase recruitment domain family member 11. (1089 aa)
	NLRC4	NLR family CARD domain containing 4. (950 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (555 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (946 aa)
	RBCK1	RANBP2-type and C3HC4-type zinc finger containing 1. (454 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	H9GCY1_ANOCA	Rap1_C domain-containing protein. (116 aa)
	IL18R1	Interleukin 18 receptor 1. (537 aa)
	sharpin	Uncharacterized protein. (703 aa)
	TRAF2	TNF receptor-associated factor. (432 aa)
	PYCARD	PYD and CARD domain containing. (192 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	RIPK4	Receptor interacting serine/threonine kinase 4. (788 aa)
	EP300	E1A binding protein p300. (2484 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (548 aa)
	DHX9	DExH-box helicase 9. (1261 aa)
	TRIM8	Tripartite motif containing 8. (551 aa)
	rnf31	Uncharacterized protein. (851 aa)
	DDRGK1	DDRGK domain containing 1. (287 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (950 aa)
	RNF25	Ring finger protein 25. (519 aa)
	rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	TRIM14	Tripartite motif containing 14. (515 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
	PSMA6	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (891 aa)
	ANKRD42	Ankyrin repeat domain 42. (522 aa)
	SLCO3A1	Solute carrier organic anion transporter family member. (508 aa)
	TRAPPC9	Trafficking protein particle complex 9. (1001 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (701 aa)
	LOC100564467	Catalase domain-containing protein. (365 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	EP300	ENSACAP00000014509	ENSACAP00000005074	Amyloid beta precursor protein.	E1A binding protein p300.	0.585
CARD11	CHUK	ENSACAP00000008377	ENSACAP00000011973	Caspase recruitment domain family member 11.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.731
CARD11	IKBKB	ENSACAP00000008377	ENSACAP00000012680	Caspase recruitment domain family member 11.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.695
CARD11	LOC103279342	ENSACAP00000008377	ENSACAP00000019370	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.449
CARD11	MALT1	ENSACAP00000008377	ENSACAP00000019315	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.959
CARD11	RIPK2	ENSACAP00000008377	ENSACAP00000010082	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.449
CARD11	TRAF6	ENSACAP00000008377	ENSACAP00000005007	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.801
CARD14	MALT1	ENSACAP00000015505	ENSACAP00000019315	Caspase recruitment domain family member 14.	MALT1 paracaspase.	0.551
CAV1	FLOT1	ENSACAP00000006424	ENSACAP00000016956	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.585
CAV1	FLOT2	ENSACAP00000006424	ENSACAP00000007849	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.465
CAV3	FLOT1	ENSACAP00000011656	ENSACAP00000016956	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.565
CAV3	FLOT2	ENSACAP00000011656	ENSACAP00000007849	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.465
CD40LG	H9GGH2_ANOCA	ENSACAP00000020298	ENSACAP00000010321	CD40 ligand; Belongs to the tumor necrosis factor family.	MATH domain-containing protein.	0.552
CD40LG	H9GHU4_ANOCA	ENSACAP00000020298	ENSACAP00000011338	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.978
CD40LG	H9GM92_ANOCA	ENSACAP00000020298	ENSACAP00000015126	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.418
CD40LG	TNFRSF11A	ENSACAP00000020298	ENSACAP00000021073	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 11a.	0.562
CD40LG	TNFSF11	ENSACAP00000020298	ENSACAP00000001868	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.589
CD40LG	TRAF2	ENSACAP00000020298	ENSACAP00000006987	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor.	0.552
CD40LG	TRAF5	ENSACAP00000020298	ENSACAP00000016112	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.579
CD40LG	TRAF6	ENSACAP00000020298	ENSACAP00000005007	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.410