(19 nodes) ERK1 and ERK2 cascade network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G1KXB0_ANOCA	DUF3496 domain-containing protein. (534 aa)
	flcn	UDENN FLCN/SMCR8-type domain-containing protein. (565 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1041 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (457 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (950 aa)
	HESX1	HESX homeobox 1. (104 aa)
	KARS1	Lysine--tRNA ligase. (636 aa)
	TBC1D10C	TBC1 domain family member 10C. (371 aa)
	EDN1	Endothelin 1. (209 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (188 aa)
	KDR	Kinase insert domain receptor. (1357 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (560 aa)
	MYC	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (443 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (320 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (285 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	LOC103279342	Uncharacterized protein. (553 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	FGF2	ENSACAP00000008302	ENSACAP00000011657	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.423
EDN1	KDR	ENSACAP00000008302	ENSACAP00000009690	Endothelin 1.	Kinase insert domain receptor.	0.554
FGF18	FGF2	ENSACAP00000019366	ENSACAP00000011657	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.611
FGF18	FGF23	ENSACAP00000019366	ENSACAP00000009255	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.701
FGF18	KDR	ENSACAP00000019366	ENSACAP00000009690	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor.	0.502
FGF2	EDN1	ENSACAP00000011657	ENSACAP00000008302	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.423
FGF2	FGF18	ENSACAP00000011657	ENSACAP00000019366	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.611
FGF2	FGF23	ENSACAP00000011657	ENSACAP00000009255	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.413
FGF2	KDR	ENSACAP00000011657	ENSACAP00000009690	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor.	0.520
FGF23	FGF18	ENSACAP00000009255	ENSACAP00000019366	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.701
FGF23	FGF2	ENSACAP00000009255	ENSACAP00000011657	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.413
FGF23	KDR	ENSACAP00000009255	ENSACAP00000009690	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor.	0.475
FGF23	TNFSF11	ENSACAP00000009255	ENSACAP00000001868	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.417
ITGAV	KDR	ENSACAP00000001799	ENSACAP00000009690	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	Kinase insert domain receptor.	0.447
KDR	EDN1	ENSACAP00000009690	ENSACAP00000008302	Kinase insert domain receptor.	Endothelin 1.	0.554
KDR	FGF18	ENSACAP00000009690	ENSACAP00000019366	Kinase insert domain receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
KDR	FGF2	ENSACAP00000009690	ENSACAP00000011657	Kinase insert domain receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
KDR	FGF23	ENSACAP00000009690	ENSACAP00000009255	Kinase insert domain receptor.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.475
KDR	ITGAV	ENSACAP00000009690	ENSACAP00000001799	Kinase insert domain receptor.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.447
LOC103279342	NOD1	ENSACAP00000019370	ENSACAP00000002867	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.983