(61 nodes) Positive regulation of canonical Wnt signaling pathway network (Anolis carolinensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100554757	DUF4203 domain-containing protein. (352 aa)
	LOC100555574	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (238 aa)
	G1KSN6_ANOCA	DDE-1 domain-containing protein. (213 aa)
	RSPO1	R-spondin 1. (301 aa)
	G1KUP5_ANOCA	HTH CENPB-type domain-containing protein. (408 aa)
	G1KWN1_ANOCA	RING-type domain-containing protein. (326 aa)
	H9GTM4_ANOCA	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (271 aa)
	plekha4	PH domain-containing protein. (134 aa)
	scel	LIM zinc-binding domain-containing protein. (123 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (957 aa)
	SFRP2	Secreted frizzled related protein 2. (309 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1180 aa)
	ILK	Integrin linked kinase. (321 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (898 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (458 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	GID8	GID complex subunit 8 homolog. (228 aa)
	G1KE00_ANOCA	Uncharacterized protein. (1176 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (657 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1078 aa)
	LYPD6	LY6/PLAUR domain containing 6. (169 aa)
	TMEM9	Transmembrane protein 9. (183 aa)
	CSNK1G3	Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (448 aa)
	nle1	NLE domain-containing protein. (129 aa)
	tbl1x	Uncharacterized protein. (531 aa)
	LOC100559765	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (230 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1. (245 aa)
	WNK2	WNK lysine deficient protein kinase 2. (1884 aa)
	LOC100558465	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (616 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (417 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3560 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1311 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1286 aa)
	Amer1	Uncharacterized protein. (494 aa)
	LRRK2	Leucine rich repeat kinase 2. (2540 aa)
	dkk2	Dickkopf_N domain-containing protein. (270 aa)
	csnk1e	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2437 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (970 aa)
	LOC103282673	Uncharacterized protein. (353 aa)
	RNF146	Ring finger protein 146. (351 aa)
	LOC100566337	PPM-type phosphatase domain-containing protein. (412 aa)
	XIAP	X-linked inhibitor of apoptosis. (568 aa)
	WLS	Wnt ligand secretion mediator. (528 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (157 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
	LOC100554060	Uncharacterized protein. (1457 aa)
	CAPRIN2	Caprin family member 2. (1101 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (513 aa)
	TMEM198	Transmembrane protein 198. (358 aa)
	FAM53B	Family with sequence similarity 53 member B. (419 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (355 aa)
	DLX5	Distal-less homeobox 5. (293 aa)
	RNF220	Uncharacterized protein. (210 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (795 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
	ppm1b	PPM-type phosphatase domain-containing protein. (387 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	BAMBI	ENSACAP00000004489	ENSACAP00000007408	Aryl hydrocarbon receptor nuclear translocator like.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.413
ARNTL	CSNK1D	ENSACAP00000004489	ENSACAP00000002445	Aryl hydrocarbon receptor nuclear translocator like.	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	0.754
ARNTL	csnk1e	ENSACAP00000004489	ENSACAP00000008166	Aryl hydrocarbon receptor nuclear translocator like.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.754
BAMBI	ARNTL	ENSACAP00000007408	ENSACAP00000004489	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Aryl hydrocarbon receptor nuclear translocator like.	0.413
BAMBI	LYPD6	ENSACAP00000007408	ENSACAP00000003453	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	LY6/PLAUR domain containing 6.	0.445
CAV1	scel	ENSACAP00000006424	ENSACAP00000022909	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	LIM zinc-binding domain-containing protein.	0.440
CAV3	scel	ENSACAP00000011656	ENSACAP00000022909	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	LIM zinc-binding domain-containing protein.	0.447
CSNK1D	ARNTL	ENSACAP00000002445	ENSACAP00000004489	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Aryl hydrocarbon receptor nuclear translocator like.	0.754
G1KWN1_ANOCA	RNF220	ENSACAP00000019463	ENSACAP00000014533	RING-type domain-containing protein.	Uncharacterized protein.	0.900
LGR4	LGR5	ENSACAP00000015587	ENSACAP00000007153	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 5.	0.968
LGR4	RSPO1	ENSACAP00000015587	ENSACAP00000016945	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 1.	0.998
LGR5	LGR4	ENSACAP00000007153	ENSACAP00000015587	Leucine rich repeat containing G protein-coupled receptor 5.	Leucine rich repeat containing G protein-coupled receptor 4.	0.968
LGR5	RSPO1	ENSACAP00000007153	ENSACAP00000016945	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 1.	0.996
LGR5	SFRP2	ENSACAP00000007153	ENSACAP00000015499	Leucine rich repeat containing G protein-coupled receptor 5.	Secreted frizzled related protein 2.	0.688
LGR5	TNKS	ENSACAP00000007153	ENSACAP00000002746	Leucine rich repeat containing G protein-coupled receptor 5.	Poly [ADP-ribose] polymerase.	0.466
LGR5	TNKS2	ENSACAP00000007153	ENSACAP00000007709	Leucine rich repeat containing G protein-coupled receptor 5.	Poly [ADP-ribose] polymerase.	0.466
LOC100554757	XIAP	ENSACAP00000015085	ENSACAP00000011315	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.433
LOC100566337	PPM1A	ENSACAP00000010637	ENSACAP00000014928	PPM-type phosphatase domain-containing protein.	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	0.903
LYPD6	BAMBI	ENSACAP00000003453	ENSACAP00000007408	LY6/PLAUR domain containing 6.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.445
PPM1A	LOC100566337	ENSACAP00000014928	ENSACAP00000010637	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	PPM-type phosphatase domain-containing protein.	0.903