(25 nodes) Cellular senescence network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HMGA1	High mobility group AT-hook 1. (110 aa)
	LOC100562668	ANK_REP_REGION domain-containing protein. (127 aa)
	TBX2	T-box transcription factor 2. (337 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1473 aa)
	MNT	MAX network transcriptional repressor. (271 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (836 aa)
	SIRT1	Sirtuin 1. (634 aa)
	ECRG4	ECRG4 augurin precursor. (150 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (239 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (473 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	SRF	Serum response factor. (474 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (657 aa)
	brca2	Tower domain-containing protein. (1241 aa)
	hmga2	Uncharacterized protein. (72 aa)
	WRN	WRN RecQ like helicase. (1315 aa)
	H9G6W7_ANOCA	Uncharacterized protein. (101 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (369 aa)
	SMC5	Structural maintenance of chromosomes 5. (1079 aa)
	LOC100563414	Uncharacterized protein. (156 aa)
	SMC6	Structural maintenance of chromosomes 6. (1117 aa)
	ID2	Inhibitor of DNA binding 2. (137 aa)
	LOC100568010	Uncharacterized protein. (266 aa)
	LOC103282543	Uncharacterized protein. (158 aa)
	mnt	Uncharacterized protein. (219 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	SIRT1	ENSACAP00000004489	ENSACAP00000010385	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.816
H9G6W7_ANOCA	LOC103282543	ENSACAP00000002870	ENSACAP00000021196	Uncharacterized protein.	Uncharacterized protein.	0.836
H9G6W7_ANOCA	WRN	ENSACAP00000002870	ENSACAP00000003095	Uncharacterized protein.	WRN RecQ like helicase.	0.743
H9G6W7_ANOCA	brca2	ENSACAP00000002870	ENSACAP00000004459	Uncharacterized protein.	Tower domain-containing protein.	0.463
HMGA1	LOC100568010	ENSACAP00000020666	ENSACAP00000021987	High mobility group AT-hook 1.	Uncharacterized protein.	0.599
HMGA1	hmga2	ENSACAP00000020666	ENSACAP00000003404	High mobility group AT-hook 1.	Uncharacterized protein.	0.652
LOC100562668	LOC103282543	ENSACAP00000017269	ENSACAP00000021196	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.791
LOC100562668	SIRT1	ENSACAP00000017269	ENSACAP00000010385	ANK_REP_REGION domain-containing protein.	Sirtuin 1.	0.444
LOC100563414	TBX2	ENSACAP00000000615	ENSACAP00000015139	Uncharacterized protein.	T-box transcription factor 2.	0.891
LOC100568010	HMGA1	ENSACAP00000021987	ENSACAP00000020666	Uncharacterized protein.	High mobility group AT-hook 1.	0.599
LOC103282543	H9G6W7_ANOCA	ENSACAP00000021196	ENSACAP00000002870	Uncharacterized protein.	Uncharacterized protein.	0.836
LOC103282543	LOC100562668	ENSACAP00000021196	ENSACAP00000017269	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.791
LOC103282543	MAPKAPK5	ENSACAP00000021196	ENSACAP00000009150	Uncharacterized protein.	MAPK activated protein kinase 5.	0.497
LOC103282543	SIRT1	ENSACAP00000021196	ENSACAP00000010385	Uncharacterized protein.	Sirtuin 1.	0.912
LOC103282543	WRN	ENSACAP00000021196	ENSACAP00000003095	Uncharacterized protein.	WRN RecQ like helicase.	0.833
LOC103282543	brca2	ENSACAP00000021196	ENSACAP00000004459	Uncharacterized protein.	Tower domain-containing protein.	0.850
LOC103282543	hmga2	ENSACAP00000021196	ENSACAP00000003404	Uncharacterized protein.	Uncharacterized protein.	0.475
MAPKAPK5	LOC103282543	ENSACAP00000009150	ENSACAP00000021196	MAPK activated protein kinase 5.	Uncharacterized protein.	0.497
MNT	mnt	ENSACAP00000011527	ENSACAP00000020716	MAX network transcriptional repressor.	Uncharacterized protein.	0.900
NSMCE2	SMC5	ENSACAP00000010131	ENSACAP00000000826	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	Structural maintenance of chromosomes 5.	0.999