(44 nodes) Cellular response to alcohol network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (465 aa)
	MLC1	Modulator of VRAC current 1. (377 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (836 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (259 aa)
	LARP1	La ribonucleoprotein domain family member 1. (976 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
	GRAMD1B	GRAM domain containing 1B. (879 aa)
	XRN1	5'-3' exoribonuclease 1. (1769 aa)
	CYP7A1	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (504 aa)
	GRAMD1A	GRAM domain containing 1A. (726 aa)
	PTGFR	Prostaglandin F receptor. (364 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (229 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (565 aa)
	RECQL5	RecQ like helicase 5. (1015 aa)
	GOLPH3	Golgi phosphoprotein 3. (310 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
	LOC100561291	Uncharacterized protein; Belongs to the cytochrome P450 family. (343 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1160 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	CREB1	cAMP responsive element binding protein 1. (349 aa)
	GRAMD1C	GRAM domain containing 1C. (624 aa)
	PTGER4	Prostaglandin E receptor 4. (161 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (324 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (550 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1227 aa)
	G1KKH9_ANOCA	AC_N domain-containing protein. (356 aa)
	adcy5	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (794 aa)
	SPIDR	Scaffold protein involved in DNA repair. (990 aa)
	PTCH1	Patched 1. (1047 aa)
	brca1	Uncharacterized protein. (772 aa)
	H9GK92_ANOCA	Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	BLM	BLM RecQ like helicase. (1396 aa)
	scnn1g	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (656 aa)
	PODNL1	Podocan like 1. (584 aa)
	AKAP8	A-kinase anchoring protein 8; Belongs to the AKAP95 family. (581 aa)
	JUP	Junction plakoglobin. (748 aa)
	PODN	Podocan. (597 aa)
	ADCY3	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (734 aa)
	PTGER2	Prostaglandin E receptor 2. (304 aa)
	npas4	Uncharacterized protein. (301 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY3	ENSACAP00000007882	ENSACAP00000019460	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.578
ADCY1	ADCY6	ENSACAP00000007882	ENSACAP00000008442	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.442
ADCY1	ADCY8	ENSACAP00000007882	ENSACAP00000010472	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.955
ADCY1	G1KKH9_ANOCA	ENSACAP00000007882	ENSACAP00000010568	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.416
ADCY1	adcy5	ENSACAP00000007882	ENSACAP00000010795	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.436
ADCY3	ADCY1	ENSACAP00000019460	ENSACAP00000007882	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.578
ADCY3	ADCY6	ENSACAP00000019460	ENSACAP00000008442	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.485
ADCY3	ADCY8	ENSACAP00000019460	ENSACAP00000010472	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.609
ADCY3	G1KKH9_ANOCA	ENSACAP00000019460	ENSACAP00000010568	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.548
ADCY3	adcy5	ENSACAP00000019460	ENSACAP00000010795	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.537
ADCY6	ADCY1	ENSACAP00000008442	ENSACAP00000007882	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.442
ADCY6	ADCY3	ENSACAP00000008442	ENSACAP00000019460	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.485
ADCY6	ADCY8	ENSACAP00000008442	ENSACAP00000010472	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.451
ADCY8	ADCY1	ENSACAP00000010472	ENSACAP00000007882	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.955
ADCY8	ADCY3	ENSACAP00000010472	ENSACAP00000019460	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.609
ADCY8	ADCY6	ENSACAP00000010472	ENSACAP00000008442	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.451
ADCY8	G1KKH9_ANOCA	ENSACAP00000010472	ENSACAP00000010568	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.431
ADCY8	adcy5	ENSACAP00000010472	ENSACAP00000010795	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.448
BLM	RAD51	ENSACAP00000014045	ENSACAP00000013598	BLM RecQ like helicase.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.979
BLM	SPIDR	ENSACAP00000014045	ENSACAP00000011737	BLM RecQ like helicase.	Scaffold protein involved in DNA repair.	0.586