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| | KNTC1 | Kinetochore associated 1. (2143 aa) |
| | NUP85 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (651 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (414 aa) |
| | NSL1 | NSL1 component of MIS12 kinetochore complex. (268 aa) |
| | LOC100554279 | Uncharacterized protein. (211 aa) |
| | PHF6 | PHD finger protein 6. (363 aa) |
| | CBX1 | Chromobox 1. (189 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1405 aa) |
| | H9GBT6_ANOCA | TOG domain-containing protein. (754 aa) |
| | nabp1 | OB domain-containing protein. (212 aa) |
| | KAT8 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (474 aa) |
| | PAFAH1B1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (409 aa) |
| | NUP43 | Nucleoporin 43. (391 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1287 aa) |
| | CFDP1 | Craniofacial development protein 1; May play a role during embryogenesis. (293 aa) |
| | G1KGW4_ANOCA | FHA domain-containing protein. (1533 aa) |
| | H9GCY1_ANOCA | Rap1_C domain-containing protein. (116 aa) |
| | ten1 | Uncharacterized protein. (125 aa) |
| | FMR1 | Fragile X mental retardation 1. (618 aa) |
| | CENPI | Centromere protein I. (738 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (716 aa) |
| | ZNF276 | Zinc finger protein 276. (545 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (345 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | IKZF1 | IKAROS family zinc finger 1. (585 aa) |
| | TEP1 | Telomerase associated protein 1. (2566 aa) |
| | GPATCH11 | G-patch domain containing 11. (188 aa) |
| | KDM4B | Lysine demethylase 4B. (1090 aa) |
| | rcc2 | Uncharacterized protein. (444 aa) |
| | atrx | Uncharacterized protein. (2338 aa) |
| | NDC80 | NDC80 kinetochore complex component. (645 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (594 aa) |
| | CENPN | Centromere protein N. (372 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (465 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (388 aa) |
| | ZW10 | Zw10 kinetochore protein. (809 aa) |
| | CENPP | Centromere protein P. (286 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1233 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (729 aa) |
| | ZWILCH | Zwilch kinetochore protein. (600 aa) |
| | ZNF207 | Zinc finger protein 207. (315 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (213 aa) |
| | ska1 | Uncharacterized protein. (253 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (239 aa) |
| | mis12 | Uncharacterized protein. (204 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (761 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (723 aa) |
| | RECQL4 | RecQ like helicase 4. (1239 aa) |
| | SIRT6 | Sirtuin 6. (176 aa) |
| | CHMP4A | Charged multivesicular body protein 4A. (163 aa) |
| | esco2 | Uncharacterized protein. (594 aa) |
| | SKA2 | Spindle and kinetochore associated complex subunit 2. (130 aa) |
| | H9GHQ1_ANOCA | Uncharacterized protein. (755 aa) |
| | SMG6 | Uncharacterized protein. (1160 aa) |
| | PLK1 | Polo like kinase 1. (416 aa) |
| | Slx4 | Uncharacterized protein. (81 aa) |
| | rad50 | Zinc-hook domain-containing protein. (1312 aa) |
| | CBX3 | Chromobox 3. (184 aa) |
| | G1KN42_ANOCA | CENP-C_C domain-containing protein. (239 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1056 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (640 aa) |
| | SEH1L | SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (324 aa) |
| | CBX5 | Chromobox 5. (188 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (570 aa) |
| | CLASP2 | Cytoplasmic linker associated protein 2. (791 aa) |
| | LOC103282748 | Protein kinase domain-containing protein. (173 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | LOC100554572 | Uncharacterized protein. (209 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa) |
| | kdm4a | Uncharacterized protein. (1048 aa) |
| | bub1b | BUB1 N-terminal domain-containing protein. (1062 aa) |
| | TELO2 | Telomere maintenance 2. (690 aa) |
| | KMT5B | Lysine methyltransferase 5B. (888 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (596 aa) |
| | DYNLT3 | Dynein light chain Tctex-type 3. (116 aa) |
| | kif2c | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (719 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1236 aa) |
| | bod1 | Uncharacterized protein. (193 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (200 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | KIF18A | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (920 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1215 aa) |
| | CENPK | Centromere protein K. (285 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (444 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (463 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (629 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa) |
| | NEK2 | NIMA related kinase 2. (446 aa) |
| | CENPH | Centromere protein H. (237 aa) |
| | NUP37 | Nucleoporin 37. (326 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (139 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (172 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (346 aa) |
| | TTK | TTK protein kinase. (883 aa) |
| | Ccdc155 | Uncharacterized protein. (330 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (326 aa) |
| | H9GPD7_ANOCA | INCENP_ARK-bind domain-containing protein. (857 aa) |
| | H9GPE2_ANOCA | Uncharacterized protein. (849 aa) |
| | ndel1 | NudE neurodevelopment protein 1 like 1. (347 aa) |
| | LOC100563247 | Uncharacterized protein. (1136 aa) |
| | smg6 | PINc domain-containing protein. (144 aa) |
| | G1KUZ5_ANOCA | Protein kinase domain-containing protein. (429 aa) |
| | G1KVB7_ANOCA | Uncharacterized protein. (163 aa) |
| | LOC100558745 | Nbl1_Borealin_N domain-containing protein. (308 aa) |
| | rec8 | Rad21_Rec8 domain-containing protein. (295 aa) |
| | LOC103282595 | Uncharacterized protein. (126 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa) |
| | Incenp | INCENP_ARK-bind domain-containing protein. (352 aa) |
| | H9GSH6_ANOCA | Uncharacterized protein. (248 aa) |
| | DHX36 | DEAH-box helicase 36. (981 aa) |
| | MTBP | MDM2 binding protein. (922 aa) |
| | KMT5C | Lysine methyltransferase 5C. (472 aa) |
| | ZNF827 | Zinc finger protein 827. (763 aa) |
| | H9GT41_ANOCA | Uncharacterized protein. (189 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (774 aa) |
| | POLD1 | DNA polymerase. (1113 aa) |
| | LOC103283027 | Uncharacterized protein. (264 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2361 aa) |
| | LOC103282695 | SOSS complex subunit B2. (111 aa) |
| | NABP2 | Nucleic acid binding protein 2. (215 aa) |
| | NDE1 | NudE neurodevelopment protein 1. (174 aa) |
| | H9GVX0_ANOCA | Uncharacterized protein. (179 aa) |
| | LOC100562004 | F-box domain-containing protein. (173 aa) |
| | H9GVZ9_ANOCA | Myb-like domain-containing protein. (689 aa) |
| | cenpx | Uncharacterized protein. (83 aa) |
| | spc24 | Uncharacterized protein. (199 aa) |
| | NUDCD2 | NudC domain containing 2. (157 aa) |
| | LOC100561388 | Uncharacterized protein. (206 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (344 aa) |
| | cdca8 | Nbl1_Borealin_N domain-containing protein. (293 aa) |
| | CKAP5 | Cytoskeleton associated protein 5. (2057 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (219 aa) |
| | LOC100562150 | Shugoshin_C domain-containing protein. (970 aa) |
| | hjurp | Uncharacterized protein. (836 aa) |
| | LOC100562825 | Uncharacterized protein. (286 aa) |
| | cenpq | Centromere protein Q. (249 aa) |
| | CENPM | Centromere protein M. (139 aa) |
| | LOC100552957 | Uncharacterized protein. (721 aa) |
| | HELLS | Helicase, lymphoid specific. (750 aa) |
| | itgb3bp | Integrin subunit beta 3 binding protein. (196 aa) |
| | ercc1 | Uncharacterized protein. (297 aa) |
| | LOC100560751 | Uncharacterized protein. (697 aa) |
| | dctn1 | CAP-Gly domain-containing protein. (1253 aa) |
| | FBXO28 | Uncharacterized protein. (131 aa) |
| | atm | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (423 aa) |
| | LOC103282074 | 53-BP1_Tudor domain-containing protein. (1012 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (606 aa) |
| | RANGAP1 | Ran GTPase activating protein 1. (591 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (361 aa) |
| | dsn1 | Uncharacterized protein. (281 aa) |
| | CLASP1 | Cytoplasmic linker associated protein 1. (1600 aa) |
| | Sgo2 | Uncharacterized protein. (133 aa) |
| | KDM4C | Lysine demethylase 4C. (1050 aa) |
| | brca2 | Tower domain-containing protein. (1241 aa) |
| | xrcc1 | Uncharacterized protein. (656 aa) |
| | NUP107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (1052 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1568 aa) |
| | H9G8I9_ANOCA | Uncharacterized protein. (83 aa) |
| | Tinf2 | TINF2_N domain-containing protein. (223 aa) |
| | mdp1 | Uncharacterized protein. (74 aa) |
| | LOC103282328 | Rad21_Rec8_N domain-containing protein. (256 aa) |
| | baz1b | WSD domain-containing protein. (105 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (842 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (232 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (696 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | rbbp4 | RB binding protein 4, chromatin remodeling factor. (435 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (383 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | WRN | WRN RecQ like helicase. (1315 aa) |
| | DCTN6 | Dynactin subunit 6. (195 aa) |
| | LOC100556408 | FAT domain-containing protein. (2448 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1286 aa) |
| | MIS18A | MIS18 kinetochore protein A. (190 aa) |
| | Ska3 | Uncharacterized protein. (52 aa) |
| | ZNF330 | Zinc finger protein 330. (319 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | cenpu | Uncharacterized protein. (307 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1533 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (309 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1021 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (3013 aa) |
| | ORC2 | Origin recognition complex subunit 2. (562 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2366 aa) |
| | DCTN5 | Dynactin subunit 5. (185 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1117 aa) |
| | CHAMP1 | Chromosome alignment maintaining phosphoprotein 1. (812 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1334 aa) |
| | Cenpt | CENP-T_C domain-containing protein. (70 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa) |
| | POT1 | Protection of telomeres 1. (774 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (111 aa) |
| | SPC25 | SPC25 component of NDC80 kinetochore complex. (215 aa) |
| | ZNF618 | Zinc finger protein 618. (884 aa) |
| | NUP133 | Nucleoporin 133. (1144 aa) |
| | NCAPD3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1494 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1079 aa) |
| | CENPO | Centromere protein O. (320 aa) |
| | AHCTF1 | AT-hook containing transcription factor 1. (2272 aa) |
| | CHRAC1 | Chromatin accessibility complex subunit 1. (138 aa) |
| | SGO1 | Shugoshin 1. (534 aa) |
| | SPOUT1 | SPOUT domain containing methyltransferase 1. (326 aa) |
| | CENPF | Centromere protein F. (2167 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (803 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (281 aa) |
| | RASSF2 | Ras association domain family member 2. (326 aa) |
| | NUF2 | NUF2 component of NDC80 kinetochore complex. (459 aa) |
