STRINGSTRING
LGMN LGMN DDX11 DDX11 ABCC8 ABCC8 LOC100560601 LOC100560601 KLF11 KLF11 PCSK9 PCSK9 GOT1L1 GOT1L1 LOC103282369 LOC103282369 H9G3K4_ANOCA H9G3K4_ANOCA LPIN1 LPIN1 H9G3L9_ANOCA H9G3L9_ANOCA MTOR MTOR SP1 SP1 SCAP SCAP SLC30A10 SLC30A10 PCK2 PCK2 EPRS1 EPRS1 INSIG2 INSIG2 JAG1 JAG1 nfkbia nfkbia GLP1R GLP1R L7MZH3_ANOCA L7MZH3_ANOCA SRSF6 SRSF6 LOC100555750 LOC100555750 ADIPOQ ADIPOQ CDC6 CDC6 GPLD1 GPLD1 NOD1 NOD1 AKT2 AKT2 UMODL1 UMODL1 gsk3a gsk3a WDTC1 WDTC1 RAB12 RAB12 RUSC1 RUSC1 RB1 RB1 PDPK1 PDPK1 GOT1 GOT1 GSK3B GSK3B RAB31 RAB31 L7MZK4_ANOCA L7MZK4_ANOCA PTPN1 PTPN1 IRS1 IRS1 EDNRA EDNRA JAK2 JAK2 TSC1 TSC1 LOC100564878 LOC100564878 GNRHR GNRHR LOC100555537 LOC100555537 LRP6 LRP6 AGTR2 AGTR2 SLC27A1 SLC27A1 RANGAP1 RANGAP1 SRSF5 SRSF5 eif6 eif6 GPER1 GPER1 APPL1 APPL1 CRHR2 CRHR2 STXBP3 STXBP3 IRF6 IRF6 DNAI1 DNAI1 GHRHR GHRHR G1KF58_ANOCA G1KF58_ANOCA STAT1 STAT1 PARP1 PARP1 GRB2 GRB2 CAV1 CAV1 CAV2 CAV2 AKT3 AKT3 AGTR1 AGTR1 SOGA1 SOGA1 KLF3 KLF3 NCOA5 NCOA5 PHEX PHEX LOC100558713 LOC100558713 MEAK7 MEAK7 RAMP3 RAMP3 CRHBP CRHBP NR4A2 NR4A2 TRIB3 TRIB3 ROCK1 ROCK1 IGF1R IGF1R EIF4EBP2 EIF4EBP2 LOC100561291 LOC100561291 EDN1 EDN1 GCLC GCLC TYK2 TYK2 HADHA HADHA H9GE80_ANOCA H9GE80_ANOCA JAK1 JAK1 RAB15 RAB15 NR4A3 NR4A3 ITGA4 ITGA4 LPIN2 LPIN2 KBTBD2 KBTBD2 IGF2 IGF2 CREB1 CREB1 STAT6 STAT6 BTG2 BTG2 SMPD3 SMPD3 RIPK2 RIPK2 SLC27A4 SLC27A4 Pik3r2 Pik3r2 SIRT1 SIRT1 ADCY8 ADCY8 GHR GHR H9GGQ9_ANOCA H9GGQ9_ANOCA EIF2B5 EIF2B5 SORT1 SORT1 OTOP1 OTOP1 INSIG1 INSIG1 SESN2 SESN2 LOC103279683 LOC103279683 CAPN10 CAPN10 EREG EREG SYAP1 SYAP1 H9GHN7_ANOCA H9GHN7_ANOCA LPIN3 LPIN3 AKT1 AKT1 CAV3 CAV3 LOC103282116 LOC103282116 ANXA1 ANXA1 GFER GFER Cpeb2 Cpeb2 KHK KHK NFE2L2 NFE2L2 EEF2K EEF2K DDR2 DDR2 SOCS2 SOCS2 IRS4 IRS4 CYFIP1 CYFIP1 pik3r2 pik3r2 PCSK1 PCSK1 LOC100555670 LOC100555670 APRT APRT PPARG PPARG PTPN2 PTPN2 RAB10 RAB10 H9GK89_ANOCA H9GK89_ANOCA H9GK92_ANOCA H9GK92_ANOCA ZDHHC7 ZDHHC7 CRY2 CRY2 APP APP OGT OGT RAB8A RAB8A FOXO4 FOXO4 CRY1 CRY1 LOC100563939 LOC100563939 INSRR INSRR INPPL1 INPPL1 ZNF106 ZNF106 PODNL1 PODNL1 CSRP3 CSRP3 pik3r3 pik3r3 PRKCI PRKCI PSEN1 PSEN1 PIK3R1 PIK3R1 PCK1 PCK1 GHSR GHSR ARHGEF2 ARHGEF2 TIMELESS TIMELESS FOXO1 FOXO1 itgb3 itgb3 SLC9A1 SLC9A1 NR4A1 NR4A1 TNFAIP3 TNFAIP3 C2CD5 C2CD5 STXBP4 STXBP4 TSHR TSHR trim16 trim16 DENND4C DENND4C crhr1 crhr1 STAT3 STAT3 LOC100566752 LOC100566752 LYN LYN PRLH PRLH STAT2 STAT2 H9GQR4_ANOCA H9GQR4_ANOCA G1KWG1_ANOCA G1KWG1_ANOCA PODN PODN LOC103279342 LOC103279342 G1KXB0_ANOCA G1KXB0_ANOCA PRLH2 PRLH2 cpeb1 cpeb1 LOC100558191 LOC100558191 INAVA INAVA LOC103282689 LOC103282689 LOC100560819 LOC100560819 mgarp mgarp LOC103282543 LOC103282543 LOC100563474 LOC100563474 LOC103281523 LOC103281523 KCNQ1 KCNQ1 LOC100556404 LOC100556404 AREG AREG CHMP5 CHMP5 SLC2A4 SLC2A4 LOC100561963 LOC100561963 INHBB INHBB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LGMNLegumain. (438 aa)
DDX11DEAD/H-box helicase 11. (914 aa)
ABCC8ATP binding cassette subfamily C member 8. (1604 aa)
LOC100560601Insulin like growth factor binding protein 5. (146 aa)
KLF11Kruppel like factor 11. (529 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (690 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (407 aa)
LOC103282369PG_binding_1 domain-containing protein. (128 aa)
H9G3K4_ANOCAUncharacterized protein. (165 aa)
LPIN1Lipin 1. (937 aa)
H9G3L9_ANOCADelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (545 aa)
MTORSerine/threonine-protein kinase TOR. (2314 aa)
SP1Sp1 transcription factor. (725 aa)
SCAPSREBF chaperone. (1261 aa)
SLC30A10Solute carrier family 30 member 10. (413 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (741 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1524 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (233 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1217 aa)
nfkbiaANK_REP_REGION domain-containing protein. (310 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (490 aa)
L7MZH3_ANOCAUncharacterized protein. (508 aa)
SRSF6Serine and arginine rich splicing factor 6. (349 aa)
LOC100555750Uncharacterized protein; Belongs to the prion family. (253 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (252 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (836 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (950 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
UMODL1Uromodulin like 1. (1330 aa)
gsk3aProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (388 aa)
WDTC1WD and tetratricopeptide repeats 1. (697 aa)
RAB12RAB12, member RAS oncogene family. (258 aa)
RUSC1RUN and SH3 domain containing 1. (791 aa)
RB1RB transcriptional corepressor 1. (901 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (546 aa)
GOT1Aspartate aminotransferase. (415 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
RAB31RAB31, member RAS oncogene family. (196 aa)
L7MZK4_ANOCAUncharacterized protein. (62 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (361 aa)
IRS1Insulin receptor substrate 1. (1168 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (411 aa)
JAK2Tyrosine-protein kinase. (1129 aa)
TSC1TSC complex subunit 1. (1234 aa)
LOC100564878Uncharacterized protein; Belongs to the potassium channel family. (632 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (379 aa)
LOC100555537FAD_binding_7 domain-containing protein. (392 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
AGTR2Angiotensin II receptor type 2. (383 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
RANGAP1Ran GTPase activating protein 1. (591 aa)
SRSF5Serine and arginine rich splicing factor 5. (267 aa)
eif6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (347 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
CRHR2Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (423 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (600 aa)
IRF6Interferon regulatory factor 6. (464 aa)
DNAI1Dynein axonemal intermediate chain 1. (710 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (435 aa)
G1KF58_ANOCAUncharacterized protein. (603 aa)
STAT1Signal transducer and activator of transcription 1. (1217 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1006 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1436 aa)
KLF3Kruppel like factor 3. (317 aa)
NCOA5Nuclear receptor coactivator 5. (564 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (751 aa)
LOC100558713Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (189 aa)
MEAK7MTOR associated protein, eak-7 homolog. (466 aa)
RAMP3Receptor activity modifying protein 3. (147 aa)
CRHBPCorticotropin releasing hormone binding protein. (405 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (638 aa)
TRIB3Tribbles pseudokinase 3. (258 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (124 aa)
LOC100561291Uncharacterized protein; Belongs to the cytochrome P450 family. (343 aa)
EDN1Endothelin 1. (209 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (647 aa)
H9GE80_ANOCAUncharacterized protein. (859 aa)
JAK1Tyrosine-protein kinase. (1158 aa)
RAB15RAB15, member RAS oncogene family. (213 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (621 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1040 aa)
LPIN2Lipin 2. (891 aa)
KBTBD2Kelch repeat and BTB domain containing 2. (627 aa)
IGF2Insulin like growth factor 2. (186 aa)
CREB1cAMP responsive element binding protein 1. (349 aa)
STAT6Signal transducer and activator of transcription. (677 aa)
BTG2BTG anti-proliferation factor 2. (170 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (662 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (560 aa)
SLC27A4Solute carrier family 27 member 4. (407 aa)
Pik3r2Uncharacterized protein. (215 aa)
SIRT1Sirtuin 1. (634 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1227 aa)
GHRGrowth hormone receptor. (620 aa)
H9GGQ9_ANOCAUncharacterized protein. (95 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (706 aa)
SORT1Sortilin. (875 aa)
OTOP1Otopetrin 1. (576 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (262 aa)
SESN2Uncharacterized protein. (499 aa)
LOC103279683Uncharacterized protein. (553 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (680 aa)
EREGEpiregulin. (167 aa)
SYAP1Synapse associated protein 1. (355 aa)
H9GHN7_ANOCAUncharacterized protein. (97 aa)
LPIN3Lipin 3. (886 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (157 aa)
LOC103282116RAB8B, member RAS oncogene family. (100 aa)
ANXA1Annexin. (342 aa)
GFERSulfhydryl oxidase. (167 aa)
Cpeb2Uncharacterized protein. (305 aa)
KHKKetohexokinase. (152 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
EEF2KEukaryotic elongation factor 2 kinase. (762 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (851 aa)
SOCS2Suppressor of cytokine signaling 2. (186 aa)
IRS4Insulin receptor substrate 4. (976 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1254 aa)
pik3r2Uncharacterized protein. (305 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (908 aa)
LOC100555670Uncharacterized protein. (218 aa)
APRTAdenine phosphoribosyltransferase. (179 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (513 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (422 aa)
RAB10RAB10, member RAS oncogene family. (196 aa)
H9GK89_ANOCAUncharacterized protein. (545 aa)
H9GK92_ANOCAUncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (307 aa)
CRY2Cryptochrome circadian regulator 2. (586 aa)
APPAmyloid beta precursor protein. (776 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1036 aa)
RAB8ARAB8A, member RAS oncogene family. (181 aa)
FOXO4Forkhead box O4. (539 aa)
CRY1Cryptochrome circadian regulator 1. (621 aa)
LOC100563939G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
INSRRTyrosine-protein kinase receptor. (1377 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1202 aa)
ZNF106Zinc finger protein 106. (1872 aa)
PODNL1Podocan like 1. (584 aa)
CSRP3Cysteine and glycine rich protein 3. (193 aa)
pik3r3Uncharacterized protein. (473 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (383 aa)
TIMELESSTimeless circadian regulator. (1204 aa)
FOXO1Forkhead box O1. (633 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (585 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (711 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (584 aa)
TNFAIP3TNF alpha induced protein 3. (829 aa)
C2CD5C2 calcium dependent domain containing 5. (1081 aa)
STXBP4Syntaxin binding protein 4. (538 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (704 aa)
trim16B30.2/SPRY domain-containing protein. (612 aa)
DENND4CDENN domain containing 4C. (1960 aa)
crhr1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (412 aa)
STAT3Signal transducer and activator of transcription. (773 aa)
LOC100566752Signal transducer and activator of transcription. (782 aa)
LYNTyrosine-protein kinase. (514 aa)
PRLHProlactin releasing hormone. (64 aa)
STAT2Signal transducer and activator of transcription. (825 aa)
H9GQR4_ANOCAUncharacterized protein. (458 aa)
G1KWG1_ANOCAIGFBP N-terminal domain-containing protein. (51 aa)
PODNPodocan. (597 aa)
LOC103279342Uncharacterized protein. (553 aa)
G1KXB0_ANOCADUF3496 domain-containing protein. (534 aa)
PRLH2Prolactin releasing hormone 2. (107 aa)
cpeb1Uncharacterized protein. (543 aa)
LOC100558191IPPc domain-containing protein. (202 aa)
INAVAInnate immunity activator. (602 aa)
LOC103282689IPPc domain-containing protein. (201 aa)
LOC100560819G_PROTEIN_RECEP_F1_2 domain-containing protein. (317 aa)
mgarpAIF-MLS domain-containing protein. (88 aa)
LOC103282543Uncharacterized protein. (158 aa)
LOC100563474Uncharacterized protein. (204 aa)
LOC103281523G_PROTEIN_RECEP_F1_2 domain-containing protein. (339 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (707 aa)
LOC100556404Uncharacterized protein. (261 aa)
AREGAmphiregulin. (175 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (467 aa)
LOC100561963Photolyase/cryptochrome alpha/beta domain-containing protein. (554 aa)
INHBBInhibin subunit beta B. (404 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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