(24 nodes) Site of double-strand break network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC100566976	Phosphoinositide phospholipase C. (889 aa)
	LOC103282074	53-BP1_Tudor domain-containing protein. (1012 aa)
	iffo1	IF rod domain-containing protein; Belongs to the intermediate filament family. (558 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (668 aa)
	TONSL	Tonsoku like, DNA repair protein. (1236 aa)
	WDR70	WD repeat domain 70. (646 aa)
	G1KJZ5_ANOCA	Uncharacterized protein. (266 aa)
	POLL	DNA polymerase lambda; Belongs to the DNA polymerase type-X family. (574 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (568 aa)
	PARP3	Poly [ADP-ribose] polymerase. (542 aa)
	IFFO2	Intermediate filament family orphan 2; Belongs to the intermediate filament family. (276 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (938 aa)
	SMARCAD1	Uncharacterized protein. (1024 aa)
	RNF169	Ring finger protein 169. (592 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (577 aa)
	RNF138	Ring finger protein 138. (288 aa)
	H9GQ09_ANOCA	FAM35_C domain-containing protein. (867 aa)
	LOC103282487	FAM35_C domain-containing protein. (146 aa)
	APLF	Aprataxin and PNKP like factor. (511 aa)
	H9GU15_ANOCA	Uncharacterized protein. (73 aa)
	LOC103281908	Phosphoinositide phospholipase C. (334 aa)
	FAM178B	Family with sequence similarity 178 member B. (461 aa)
	UFL1	UFM1 specific ligase 1. (649 aa)
	slf2	Uncharacterized protein. (1187 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	PARP3	ENSACAP00000018834	ENSACAP00000011424	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase.	0.695
APLF	PNKP	ENSACAP00000018834	ENSACAP00000012550	Aprataxin and PNKP like factor.	Polynucleotide kinase 3'-phosphatase.	0.561
APLF	POLL	ENSACAP00000018834	ENSACAP00000011615	Aprataxin and PNKP like factor.	DNA polymerase lambda; Belongs to the DNA polymerase type-X family.	0.481
LOC100566976	LOC103281908	ENSACAP00000001816	ENSACAP00000021510	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.934
LOC103281908	LOC100566976	ENSACAP00000021510	ENSACAP00000001816	Phosphoinositide phospholipase C.	Phosphoinositide phospholipase C.	0.934
LOC103282074	LOC103282487	ENSACAP00000005073	ENSACAP00000018557	53-BP1_Tudor domain-containing protein.	FAM35_C domain-containing protein.	0.436
LOC103282074	RNF168	ENSACAP00000005073	ENSACAP00000016018	53-BP1_Tudor domain-containing protein.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.937
LOC103282074	RNF169	ENSACAP00000005073	ENSACAP00000014165	53-BP1_Tudor domain-containing protein.	Ring finger protein 169.	0.779
LOC103282074	SLF1	ENSACAP00000005073	ENSACAP00000013011	53-BP1_Tudor domain-containing protein.	SMC5-SMC6 complex localization factor 1.	0.911
LOC103282074	SMARCAD1	ENSACAP00000005073	ENSACAP00000013310	53-BP1_Tudor domain-containing protein.	Uncharacterized protein.	0.525
LOC103282487	LOC103282074	ENSACAP00000018557	ENSACAP00000005073	FAM35_C domain-containing protein.	53-BP1_Tudor domain-containing protein.	0.436
PARP3	APLF	ENSACAP00000011424	ENSACAP00000018834	Poly [ADP-ribose] polymerase.	Aprataxin and PNKP like factor.	0.695
PARP3	POLL	ENSACAP00000011424	ENSACAP00000011615	Poly [ADP-ribose] polymerase.	DNA polymerase lambda; Belongs to the DNA polymerase type-X family.	0.477
PNKP	APLF	ENSACAP00000012550	ENSACAP00000018834	Polynucleotide kinase 3'-phosphatase.	Aprataxin and PNKP like factor.	0.561
PNKP	POLL	ENSACAP00000012550	ENSACAP00000011615	Polynucleotide kinase 3'-phosphatase.	DNA polymerase lambda; Belongs to the DNA polymerase type-X family.	0.716
POLL	APLF	ENSACAP00000011615	ENSACAP00000018834	DNA polymerase lambda; Belongs to the DNA polymerase type-X family.	Aprataxin and PNKP like factor.	0.481
POLL	PARP3	ENSACAP00000011615	ENSACAP00000011424	DNA polymerase lambda; Belongs to the DNA polymerase type-X family.	Poly [ADP-ribose] polymerase.	0.477
POLL	PNKP	ENSACAP00000011615	ENSACAP00000012550	DNA polymerase lambda; Belongs to the DNA polymerase type-X family.	Polynucleotide kinase 3'-phosphatase.	0.716
RNF168	LOC103282074	ENSACAP00000016018	ENSACAP00000005073	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	53-BP1_Tudor domain-containing protein.	0.937
RNF168	RNF169	ENSACAP00000016018	ENSACAP00000014165	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	Ring finger protein 169.	0.593