(14 nodes) Kringle network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F12	Coagulation factor XII. (591 aa)
	HGFAC	HGF activator; Belongs to the peptidase S1 family. (266 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (612 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (801 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (950 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (964 aa)
	LOC100551814	Uncharacterized protein; Belongs to the peptidase S1 family. (764 aa)
	HABP2	Hyaluronan binding protein 2. (569 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (555 aa)
	PRSS12	Serine protease 12; Belongs to the peptidase S1 family. (828 aa)
	plau	Uncharacterized protein. (435 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (701 aa)
	KREMEN2	Kringle containing transmembrane protein 2. (479 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (946 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F12	HABP2	ENSACAP00000006162	ENSACAP00000010222	Coagulation factor XII.	Hyaluronan binding protein 2.	0.411
F12	MST1	ENSACAP00000006162	ENSACAP00000008758	Coagulation factor XII.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.544
F12	PLG	ENSACAP00000006162	ENSACAP00000003302	Coagulation factor XII.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.468
F12	f2	ENSACAP00000006162	ENSACAP00000003746	Coagulation factor XII.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.510
HABP2	F12	ENSACAP00000010222	ENSACAP00000006162	Hyaluronan binding protein 2.	Coagulation factor XII.	0.411
HABP2	HGFAC	ENSACAP00000010222	ENSACAP00000005668	Hyaluronan binding protein 2.	HGF activator; Belongs to the peptidase S1 family.	0.410
HABP2	PLG	ENSACAP00000010222	ENSACAP00000003302	Hyaluronan binding protein 2.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.511
HABP2	f2	ENSACAP00000010222	ENSACAP00000003746	Hyaluronan binding protein 2.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.488
HGFAC	HABP2	ENSACAP00000005668	ENSACAP00000010222	HGF activator; Belongs to the peptidase S1 family.	Hyaluronan binding protein 2.	0.410
HGFAC	MST1	ENSACAP00000005668	ENSACAP00000008758	HGF activator; Belongs to the peptidase S1 family.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.580
HGFAC	PLG	ENSACAP00000005668	ENSACAP00000003302	HGF activator; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.491
HGFAC	f2	ENSACAP00000005668	ENSACAP00000003746	HGF activator; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.484
MST1	F12	ENSACAP00000008758	ENSACAP00000006162	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	Coagulation factor XII.	0.544
MST1	HGFAC	ENSACAP00000008758	ENSACAP00000005668	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	HGF activator; Belongs to the peptidase S1 family.	0.580
MST1	PLG	ENSACAP00000008758	ENSACAP00000003302	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.402
MUSK	PRSS12	ENSACAP00000001049	ENSACAP00000013535	Muscle associated receptor tyrosine kinase.	Serine protease 12; Belongs to the peptidase S1 family.	0.410
PLAT	PLG	ENSACAP00000012511	ENSACAP00000003302	Plasminogen activator; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.898
PLG	F12	ENSACAP00000003302	ENSACAP00000006162	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Coagulation factor XII.	0.468
PLG	HABP2	ENSACAP00000003302	ENSACAP00000010222	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Hyaluronan binding protein 2.	0.511
PLG	HGFAC	ENSACAP00000003302	ENSACAP00000005668	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	HGF activator; Belongs to the peptidase S1 family.	0.491