(11 nodes) Gamma-carboxyglutamic acid-rich (GLA) domain network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PROC	Protein C, inactivator of coagulation factors Va and VIIIa. (430 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (612 aa)
	PROS1	Protein S. (764 aa)
	PROZ	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (406 aa)
	PRRG4	Proline rich and Gla domain 4. (222 aa)
	F7	Coagulation factor VII. (426 aa)
	PRRG1	Proline rich and Gla domain 1. (214 aa)
	F9	Coagulation factor IX. (402 aa)
	PRRG3	Proline rich and Gla domain 3. (251 aa)
	MGP	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (105 aa)
	F10	Coagulation factor X. (483 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F10	PROC	ENSACAP00000006865	ENSACAP00000005628	Coagulation factor X.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.532
F10	f2	ENSACAP00000006865	ENSACAP00000003746	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.785
F7	PROC	ENSACAP00000020514	ENSACAP00000005628	Coagulation factor VII.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.523
F7	f2	ENSACAP00000020514	ENSACAP00000003746	Coagulation factor VII.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.782
F9	PROC	ENSACAP00000014356	ENSACAP00000005628	Coagulation factor IX.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.530
F9	f2	ENSACAP00000014356	ENSACAP00000003746	Coagulation factor IX.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.782
MGP	PROS1	ENSACAP00000010585	ENSACAP00000000756	Matrix Gla protein; Associates with the organic matrix of bone and cartilage.	Protein S.	0.552
PROC	F10	ENSACAP00000005628	ENSACAP00000006865	Protein C, inactivator of coagulation factors Va and VIIIa.	Coagulation factor X.	0.532
PROC	F7	ENSACAP00000005628	ENSACAP00000020514	Protein C, inactivator of coagulation factors Va and VIIIa.	Coagulation factor VII.	0.523
PROC	F9	ENSACAP00000005628	ENSACAP00000014356	Protein C, inactivator of coagulation factors Va and VIIIa.	Coagulation factor IX.	0.530
PROC	PROS1	ENSACAP00000005628	ENSACAP00000000756	Protein C, inactivator of coagulation factors Va and VIIIa.	Protein S.	0.717
PROC	PROZ	ENSACAP00000005628	ENSACAP00000000176	Protein C, inactivator of coagulation factors Va and VIIIa.	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	0.532
PROC	f2	ENSACAP00000005628	ENSACAP00000003746	Protein C, inactivator of coagulation factors Va and VIIIa.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.969
PROS1	MGP	ENSACAP00000000756	ENSACAP00000010585	Protein S.	Matrix Gla protein; Associates with the organic matrix of bone and cartilage.	0.552
PROS1	PROC	ENSACAP00000000756	ENSACAP00000005628	Protein S.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.717
PROZ	PROC	ENSACAP00000000176	ENSACAP00000005628	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	Protein C, inactivator of coagulation factors Va and VIIIa.	0.532
PROZ	f2	ENSACAP00000000176	ENSACAP00000003746	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.759
f2	F10	ENSACAP00000003746	ENSACAP00000006865	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.785
f2	F7	ENSACAP00000003746	ENSACAP00000020514	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VII.	0.782
f2	F9	ENSACAP00000003746	ENSACAP00000014356	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.782