(45 nodes) LDL receptor-like superfamily network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMPRSS7	Transmembrane serine protease 7; Belongs to the peptidase S1 family. (828 aa)
	LDLR	Low density lipoprotein receptor. (863 aa)
	LRP10	LDL receptor related protein 10. (617 aa)
	MFRP	Membrane frizzled-related protein. (445 aa)
	sorl1	Uncharacterized protein. (1207 aa)
	DGCR2	DiGeorge syndrome critical region gene 2. (545 aa)
	LOC100559210	EGF-like domain-containing protein. (733 aa)
	Tmprss3	Peptidase S1 domain-containing protein. (157 aa)
	VLDLR	Very low density lipoprotein receptor. (874 aa)
	spint1	Uncharacterized protein. (514 aa)
	LRP1B	LDL receptor related protein 1B. (4512 aa)
	LRP4	LDL receptor related protein 4. (1907 aa)
	NETO1	Neuropilin and tolloid like 1. (533 aa)
	H9G890_ANOCA	Ig-like domain-containing protein; Belongs to the MHC class I family. (311 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
	LDLRAD3	Low density lipoprotein receptor class A domain containing 3. (351 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (486 aa)
	LRP3	LDL receptor related protein 3. (658 aa)
	CORIN	Corin, serine peptidase. (1063 aa)
	C8A	Complement C8 alpha chain. (596 aa)
	C8B	Complement C8 beta chain. (575 aa)
	TMPRSS4	Transmembrane serine protease 4; Belongs to the peptidase S1 family. (447 aa)
	LRP8	LDL receptor related protein 8. (936 aa)
	ALK	Tyrosine-protein kinase receptor. (1198 aa)
	LRP12	LDL receptor related protein 12. (859 aa)
	cfi	Uncharacterized protein; Belongs to the peptidase S1 family. (577 aa)
	C9	Complement C9. (591 aa)
	C7	Complement C7. (838 aa)
	LOC100566857	Uncharacterized protein. (930 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (310 aa)
	NETO2	Neuropilin and tolloid like 2. (525 aa)
	LDLRAD1	Low density lipoprotein receptor class A domain containing 1. (175 aa)
	lrp5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1627 aa)
	tmprss15	Uncharacterized protein. (848 aa)
	Tmprss9	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (384 aa)
	TMPRSS6	Transmembrane serine protease 6; Belongs to the peptidase S1 family. (775 aa)
	RXFP1	Relaxin family peptide receptor 1. (761 aa)
	SSPO	SCO-spondin. (5136 aa)
	LRP2	LDL receptor related protein 2. (4657 aa)
	ST14	Suppression of tumorigenicity 14. (860 aa)
	LOC100567051	Uncharacterized protein. (938 aa)
	LRP11	LDL receptor related protein 11. (499 aa)
	H9GVN2_ANOCA	Uncharacterized protein. (93 aa)
	Malrd1	Uncharacterized protein. (765 aa)
	LOC100563609	Uncharacterized protein. (569 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C7	C8A	ENSACAP00000010102	ENSACAP00000006737	Complement C7.	Complement C8 alpha chain.	0.540
C7	C8B	ENSACAP00000010102	ENSACAP00000006791	Complement C7.	Complement C8 beta chain.	0.540
C7	C9	ENSACAP00000010102	ENSACAP00000009962	Complement C7.	Complement C9.	0.540
C7	LOC100566857	ENSACAP00000010102	ENSACAP00000010244	Complement C7.	Uncharacterized protein.	0.540
C7	LOC100567051	ENSACAP00000010102	ENSACAP00000019044	Complement C7.	Uncharacterized protein.	0.540
C8A	C7	ENSACAP00000006737	ENSACAP00000010102	Complement C8 alpha chain.	Complement C7.	0.540
C8A	C8B	ENSACAP00000006737	ENSACAP00000006791	Complement C8 alpha chain.	Complement C8 beta chain.	0.786
C8A	C9	ENSACAP00000006737	ENSACAP00000009962	Complement C8 alpha chain.	Complement C9.	0.964
C8A	LOC100566857	ENSACAP00000006737	ENSACAP00000010244	Complement C8 alpha chain.	Uncharacterized protein.	0.590
C8A	LOC100567051	ENSACAP00000006737	ENSACAP00000019044	Complement C8 alpha chain.	Uncharacterized protein.	0.590
C8B	C7	ENSACAP00000006791	ENSACAP00000010102	Complement C8 beta chain.	Complement C7.	0.540
C8B	C8A	ENSACAP00000006791	ENSACAP00000006737	Complement C8 beta chain.	Complement C8 alpha chain.	0.786
C8B	C9	ENSACAP00000006791	ENSACAP00000009962	Complement C8 beta chain.	Complement C9.	0.722
C8B	LOC100566857	ENSACAP00000006791	ENSACAP00000010244	Complement C8 beta chain.	Uncharacterized protein.	0.616
C8B	LOC100567051	ENSACAP00000006791	ENSACAP00000019044	Complement C8 beta chain.	Uncharacterized protein.	0.616
C9	C7	ENSACAP00000009962	ENSACAP00000010102	Complement C9.	Complement C7.	0.540
C9	C8A	ENSACAP00000009962	ENSACAP00000006737	Complement C9.	Complement C8 alpha chain.	0.964
C9	C8B	ENSACAP00000009962	ENSACAP00000006791	Complement C9.	Complement C8 beta chain.	0.722
C9	LOC100563609	ENSACAP00000009962	ENSACAP00000021702	Complement C9.	Uncharacterized protein.	0.758
C9	LOC100566857	ENSACAP00000009962	ENSACAP00000010244	Complement C9.	Uncharacterized protein.	0.684