(56 nodes) FAD/NAD(P)-binding domain superfamily network (Anolis carolinensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1149 aa)
	KDM1B	Lysine demethylase 1B. (818 aa)
	GDI2	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (446 aa)
	L2HGDH	L-2-hydroxyglutarate dehydrogenase. (450 aa)
	FOXRED1	FAD dependent oxidoreductase domain containing 1. (484 aa)
	SMOX	Spermine oxidase. (535 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (476 aa)
	TXNRD1	Thioredoxin reductase 1. (532 aa)
	LOC100563852	Amine oxidase. (552 aa)
	PCYOX1L	Prenylcysteine oxidase 1 like. (511 aa)
	GDI1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
	SQLE	Squalene epoxidase. (572 aa)
	OSGIN2	Oxidative stress induced growth inhibitor family member 2. (554 aa)
	PDPR	Pyruvate dehydrogenase phosphatase regulatory subunit. (879 aa)
	AIFM3	Apoptosis inducing factor mitochondria associated 3. (692 aa)
	retsat	Uncharacterized protein. (324 aa)
	CHDH	Choline dehydrogenase. (610 aa)
	paox	Amino_oxidase domain-containing protein. (517 aa)
	LOC100566795	Amino_oxidase domain-containing protein. (502 aa)
	MICAL3	Microtubule associated monooxygenase, calponin and LIM domain containing 3. (2255 aa)
	LOC100555685	Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
	PIPOX	Pipecolic acid and sarcosine oxidase. (230 aa)
	LOC100555879	Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa)
	LOC100562854	Dimethylaniline monooxygenase [N-oxide-forming]. (542 aa)
	chm	Uncharacterized protein. (676 aa)
	TXNRD3	Thioredoxin reductase 3. (607 aa)
	SARDH	Sarcosine dehydrogenase. (774 aa)
	RNLS	Renalase, FAD dependent amine oxidase. (267 aa)
	DLD	Dihydrolipoyl dehydrogenase. (512 aa)
	CFAP61	Cilia and flagella associated protein 61. (1237 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1023 aa)
	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial. (493 aa)
	PCYOX1	Prenylcysteine oxidase 1. (405 aa)
	GPD2	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (755 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	MICAL1	Microtubule associated monooxygenase, calponin and LIM domain containing 1. (482 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (472 aa)
	PYROXD1	Pyridine nucleotide-disulphide oxidoreductase domain 1. (507 aa)
	sdha	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (664 aa)
	PPOX	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (478 aa)
	MTO1	Mitochondrial tRNA translation optimization 1. (673 aa)
	sqor	Uncharacterized protein. (378 aa)
	LOC100554362	Uncharacterized protein. (605 aa)
	PYROXD2	Pyridine nucleotide-disulphide oxidoreductase domain 2. (584 aa)
	GSR	Glutathione-disulfide reductase. (464 aa)
	LOC100567189	Amine oxidase. (495 aa)
	FMO5	Flavin-containing monooxygenase. (256 aa)
	LOC100554559	Uncharacterized protein. (594 aa)
	MAOA	Amine oxidase. (523 aa)
	LOC100564380	Amine oxidase. (523 aa)
	AIFM2	Apoptosis inducing factor mitochondria associated 2. (373 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
	DMGDH	Dimethylglycine dehydrogenase. (837 aa)
	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (681 aa)
	FOXRED2	FAD dependent oxidoreductase domain containing 2. (644 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	DLD	ENSACAP00000008812	ENSACAP00000015108	Apoptosis inducing factor mitochondria associated 1.	Dihydrolipoyl dehydrogenase.	0.466
AIFM1	GSR	ENSACAP00000008812	ENSACAP00000003290	Apoptosis inducing factor mitochondria associated 1.	Glutathione-disulfide reductase.	0.531
AIFM1	PIPOX	ENSACAP00000008812	ENSACAP00000012871	Apoptosis inducing factor mitochondria associated 1.	Pipecolic acid and sarcosine oxidase.	0.591
AIFM1	TXNRD1	ENSACAP00000008812	ENSACAP00000015738	Apoptosis inducing factor mitochondria associated 1.	Thioredoxin reductase 1.	0.430
AIFM1	TXNRD3	ENSACAP00000008812	ENSACAP00000013835	Apoptosis inducing factor mitochondria associated 1.	Thioredoxin reductase 3.	0.430
AIFM2	DLD	ENSACAP00000017515	ENSACAP00000015108	Apoptosis inducing factor mitochondria associated 2.	Dihydrolipoyl dehydrogenase.	0.430
AIFM2	GSR	ENSACAP00000017515	ENSACAP00000003290	Apoptosis inducing factor mitochondria associated 2.	Glutathione-disulfide reductase.	0.577
AIFM2	PIPOX	ENSACAP00000017515	ENSACAP00000012871	Apoptosis inducing factor mitochondria associated 2.	Pipecolic acid and sarcosine oxidase.	0.591
AIFM2	TXNRD1	ENSACAP00000017515	ENSACAP00000015738	Apoptosis inducing factor mitochondria associated 2.	Thioredoxin reductase 1.	0.430
AIFM2	TXNRD3	ENSACAP00000017515	ENSACAP00000013835	Apoptosis inducing factor mitochondria associated 2.	Thioredoxin reductase 3.	0.430
AIFM3	DLD	ENSACAP00000010903	ENSACAP00000015108	Apoptosis inducing factor mitochondria associated 3.	Dihydrolipoyl dehydrogenase.	0.430
AIFM3	GSR	ENSACAP00000010903	ENSACAP00000003290	Apoptosis inducing factor mitochondria associated 3.	Glutathione-disulfide reductase.	0.577
AIFM3	PIPOX	ENSACAP00000010903	ENSACAP00000012871	Apoptosis inducing factor mitochondria associated 3.	Pipecolic acid and sarcosine oxidase.	0.591
AIFM3	TXNRD1	ENSACAP00000010903	ENSACAP00000015738	Apoptosis inducing factor mitochondria associated 3.	Thioredoxin reductase 1.	0.431
AIFM3	TXNRD3	ENSACAP00000010903	ENSACAP00000013835	Apoptosis inducing factor mitochondria associated 3.	Thioredoxin reductase 3.	0.431
CHDH	KMO	ENSACAP00000011466	ENSACAP00000009283	Choline dehydrogenase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.469
CHDH	sqor	ENSACAP00000011466	ENSACAP00000003664	Choline dehydrogenase.	Uncharacterized protein.	0.564
COQ6	ETFDH	ENSACAP00000015933	ENSACAP00000016261	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	0.563
COQ6	FDXR	ENSACAP00000015933	ENSACAP00000005651	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.461
COQ6	KMO	ENSACAP00000015933	ENSACAP00000009283	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.559