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EFNB2 EFNB2 CFL2 CFL2 pak1 pak1 ACTR2 ACTR2 EPHA3 EPHA3 GRIN1 GRIN1 ARPC2 ARPC2 RASA1 RASA1 LOC103282369 LOC103282369 ROCK2 ROCK2 NCK2 NCK2 EFNA5 EFNA5 SRC SRC CDC42 CDC42 arpc1a arpc1a EPHA5 EPHA5 PAK3 PAK3 EPHA8 EPHA8 LOC100555639 LOC100555639 fndc3a fndc3a fmn1 fmn1 ARPC3 ARPC3 PSEN1 PSEN1 ncstn ncstn PAK2 PAK2 FNDC3B FNDC3B psenen psenen LOC103282942 LOC103282942 LYN LYN H9GQ91_ANOCA H9GQ91_ANOCA H9GQX5_ANOCA H9GQX5_ANOCA arpc5 arpc5 G1KWW5_ANOCA G1KWW5_ANOCA H9GTM6_ANOCA H9GTM6_ANOCA LOC100554656 LOC100554656 LOC100566180 LOC100566180 WASL WASL LOC107983225 LOC107983225 R4GCA3_ANOCA R4GCA3_ANOCA EFNB3 EFNB3 ARPC4 ARPC4 EPHB1 EPHB1 EFNA2 EFNA2 ARHGEF28 ARHGEF28 G1KII9_ANOCA G1KII9_ANOCA EFNB1 EFNB1 CFL1 CFL1 YES1 YES1 ARPC5L ARPC5L LOC100558640 LOC100558640 SDCBP2 SDCBP2 EPHB6 EPHB6 ROCK1 ROCK1 EPHB3 EPHB3 APH1A APH1A EPHA1 EPHA1 EPHB4 EPHB4 PSEN2 PSEN2 EPHA2 EPHA2 WAS WAS NGEF NGEF SDCBP SDCBP EPHA4 EPHA4 ITSN1 ITSN1 SDC2 SDC2 fmn2 fmn2 EPHA7 EPHA7 ACTR3 ACTR3 GRIN2B GRIN2B actr3b actr3b H9GGQ9_ANOCA H9GGQ9_ANOCA H9GGR1_ANOCA H9GGR1_ANOCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNB2Ephrin B2; Belongs to the ephrin family. (344 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
pak1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (414 aa)
EPHA3EPH receptor A3. (951 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (396 aa)
RASA1RAS p21 protein activator 1. (1018 aa)
LOC103282369PG_binding_1 domain-containing protein. (128 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
NCK2Cytoplasmic protein. (380 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (229 aa)
SRCTyrosine-protein kinase. (532 aa)
CDC42Uncharacterized protein. (80 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
EPHA5EPH receptor A5. (957 aa)
PAK3Non-specific serine/threonine protein kinase. (557 aa)
EPHA8EPH receptor A8. (959 aa)
LOC100555639Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
fndc3aUncharacterized protein. (1202 aa)
fmn1Uncharacterized protein. (494 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
ncstnNcstrn_small domain-containing protein. (340 aa)
PAK2Non-specific serine/threonine protein kinase. (527 aa)
FNDC3BFibronectin type III domain containing 3B. (1213 aa)
psenenUncharacterized protein. (101 aa)
LOC103282942Uncharacterized protein. (90 aa)
LYNTyrosine-protein kinase. (514 aa)
H9GQ91_ANOCAUncharacterized protein. (134 aa)
H9GQX5_ANOCAUncharacterized protein. (56 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (107 aa)
G1KWW5_ANOCAFibronectin type-III domain-containing protein. (175 aa)
H9GTM6_ANOCAUncharacterized protein. (980 aa)
LOC100554656CRIB domain-containing protein. (101 aa)
LOC100566180Uncharacterized protein. (443 aa)
WASLWASP like actin nucleation promoting factor. (513 aa)
LOC107983225Uncharacterized protein. (368 aa)
R4GCA3_ANOCAUncharacterized protein. (490 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (298 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
EPHB1EPH receptor B1. (1008 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (101 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1709 aa)
G1KII9_ANOCAUncharacterized protein. (409 aa)
EFNB1Ephrin B1. (255 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
YES1Tyrosine-protein kinase. (553 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (106 aa)
LOC100558640Uncharacterized protein. (697 aa)
SDCBP2Syndecan binding protein 2. (234 aa)
EPHB6EPH receptor B6. (737 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
EPHB3EPH receptor B3. (987 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
EPHA1EPH receptor A1. (972 aa)
EPHB4EPH receptor B4. (519 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (454 aa)
EPHA2EPH receptor A2. (981 aa)
WASWASP actin nucleation promoting factor. (502 aa)
NGEFNeuronal guanine nucleotide exchange factor. (605 aa)
SDCBPSyndecan binding protein. (297 aa)
EPHA4EPH receptor A4. (994 aa)
ITSN1Intersectin 1. (1712 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (205 aa)
fmn2FH2 domain-containing protein. (1454 aa)
EPHA7EPH receptor A7. (903 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1500 aa)
actr3bUncharacterized protein; Belongs to the actin family. (461 aa)
H9GGQ9_ANOCAUncharacterized protein. (95 aa)
H9GGR1_ANOCAUncharacterized protein. (239 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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