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ARPC2 ARPC2 ROCK2 ROCK2 LOC100555639 LOC100555639 fndc3a fndc3a fmn1 fmn1 FNDC3B FNDC3B ARPC3 ARPC3 arpc1a arpc1a CDC42 CDC42 SRC SRC actr3b actr3b GRIN2B GRIN2B EFNB3 EFNB3 ARPC4 ARPC4 EPHB1 EPHB1 ARHGEF28 ARHGEF28 LYN LYN arpc5 arpc5 H9GTM6_ANOCA H9GTM6_ANOCA WASL WASL EFNB2 EFNB2 CFL2 CFL2 ACTR2 ACTR2 GRIN1 GRIN1 RASA1 RASA1 EFNB1 EFNB1 CFL1 CFL1 YES1 YES1 ARPC5L ARPC5L LOC100558640 LOC100558640 EPHB6 EPHB6 ROCK1 ROCK1 EPHB3 EPHB3 WAS WAS ITSN1 ITSN1 SDC2 SDC2 fmn2 fmn2 ACTR3 ACTR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (396 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
LOC100555639Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
fndc3aUncharacterized protein. (1202 aa)
fmn1Uncharacterized protein. (494 aa)
FNDC3BFibronectin type III domain containing 3B. (1213 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
CDC42Uncharacterized protein. (80 aa)
SRCTyrosine-protein kinase. (532 aa)
actr3bUncharacterized protein; Belongs to the actin family. (461 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1500 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (298 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
EPHB1EPH receptor B1. (1008 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1709 aa)
LYNTyrosine-protein kinase. (514 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (107 aa)
H9GTM6_ANOCAUncharacterized protein. (980 aa)
WASLWASP like actin nucleation promoting factor. (513 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (344 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (414 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (814 aa)
RASA1RAS p21 protein activator 1. (1018 aa)
EFNB1Ephrin B1. (255 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
YES1Tyrosine-protein kinase. (553 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (106 aa)
LOC100558640Uncharacterized protein. (697 aa)
EPHB6EPH receptor B6. (737 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
EPHB3EPH receptor B3. (987 aa)
WASWASP actin nucleation promoting factor. (502 aa)
ITSN1Intersectin 1. (1712 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (205 aa)
fmn2FH2 domain-containing protein. (1454 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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