(20 nodes) Translesion synthesis by POLK network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

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Your Input:
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RFC2	Replication factor C subunit 2. (318 aa)
	rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (554 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	RFC1	Replication factor C subunit 1. (1146 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1247 aa)
	POLK	DNA polymerase kappa. (838 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3091 aa)
	RPA3	Replication protein A3. (121 aa)
	H9GK63_ANOCA	Uncharacterized protein. (304 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (530 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	RFC5	Replication factor C subunit 5. (342 aa)
	ubc	Uncharacterized protein. (381 aa)
	H9GRS7_ANOCA	Ubiquitin-like domain-containing protein. (33 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (69 aa)
	ATAD5	ATPase family AAA domain containing 5. (1748 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	H9GK63_ANOCA	ENSACAP00000019218	ENSACAP00000013468	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.414
ATAD5	MEIOB	ENSACAP00000019218	ENSACAP00000006034	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.733
ATAD5	PCNA	ENSACAP00000019218	ENSACAP00000000398	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.977
ATAD5	POLK	ENSACAP00000019218	ENSACAP00000008348	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.622
ATAD5	REV1	ENSACAP00000019218	ENSACAP00000008123	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.636
ATAD5	REV3L	ENSACAP00000019218	ENSACAP00000011298	ATPase family AAA domain containing 5.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.742
ATAD5	RFC1	ENSACAP00000019218	ENSACAP00000007449	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.699
ATAD5	RFC2	ENSACAP00000019218	ENSACAP00000000697	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.981
ATAD5	RFC3	ENSACAP00000019218	ENSACAP00000003823	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.989
ATAD5	RFC4	ENSACAP00000019218	ENSACAP00000007507	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.989
ATAD5	RFC5	ENSACAP00000019218	ENSACAP00000016376	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.986
ATAD5	RPA1	ENSACAP00000019218	ENSACAP00000014346	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.733
ATAD5	RPA3	ENSACAP00000019218	ENSACAP00000012819	ATPase family AAA domain containing 5.	Replication protein A3.	0.590
ATAD5	rps27a	ENSACAP00000019218	ENSACAP00000003208	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.567
ATAD5	ubc	ENSACAP00000019218	ENSACAP00000017814	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.414
H9GK63_ANOCA	ATAD5	ENSACAP00000013468	ENSACAP00000019218	Uncharacterized protein.	ATPase family AAA domain containing 5.	0.414
H9GK63_ANOCA	H9GRS7_ANOCA	ENSACAP00000013468	ENSACAP00000018978	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.883
H9GK63_ANOCA	PCNA	ENSACAP00000013468	ENSACAP00000000398	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.869
H9GK63_ANOCA	POLK	ENSACAP00000013468	ENSACAP00000008348	Uncharacterized protein.	DNA polymerase kappa.	0.645
H9GK63_ANOCA	REV1	ENSACAP00000013468	ENSACAP00000008123	Uncharacterized protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.873