(20 nodes) (2010) GnRH signaling, the gonadotrope and endocrine control of fertility. network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (466 aa)
	LOC100552643	G_PROTEIN_RECEP_F1_2 domain-containing protein. (241 aa)
	EGR1	Early growth response 1. (275 aa)
	FGFR1	Fibroblast growth factor receptor. (821 aa)
	KISS1R	KISS1 receptor. (374 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (392 aa)
	rh2	Blue-sensitive opsin; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. This opsin uses a vitamin A2 chromophore; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (355 aa)
	LOC100552424	Calmodulin. (149 aa)
	FST	Follistatin. (344 aa)
	rho	Rhodopsin; Photoreceptor. Light-induced isomerization of 11-cis to all- trans retinal triggers a conformational change that activates signaling via G-proteins; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (352 aa)
	PGR	Progesterone receptor. (387 aa)
	CALML4	Calmodulin like 4. (155 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (642 aa)
	PRL	Prolactin. (229 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	ANOS1	Anosmin 1. (682 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANOS1	FGFR1	ENSACAP00000000423	ENSACAP00000017732	Anosmin 1.	Fibroblast growth factor receptor.	0.855
CALM2	CALML4	ENSACAP00000004388	ENSACAP00000010061	Calmodulin 2; Belongs to the calmodulin family.	Calmodulin like 4.	0.905
CALML4	CALM2	ENSACAP00000010061	ENSACAP00000004388	Calmodulin like 4.	Calmodulin 2; Belongs to the calmodulin family.	0.905
DUSP4	FOS	ENSACAP00000002500	ENSACAP00000016663	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.432
EGR1	FOS	ENSACAP00000020849	ENSACAP00000016663	Early growth response 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.847
EGR1	esr1	ENSACAP00000020849	ENSACAP00000006106	Early growth response 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.492
FGFR1	ANOS1	ENSACAP00000017732	ENSACAP00000000423	Fibroblast growth factor receptor.	Anosmin 1.	0.855
FGFR1	GRB2	ENSACAP00000017732	ENSACAP00000006419	Fibroblast growth factor receptor.	Growth factor receptor bound protein 2.	0.642
FOS	DUSP4	ENSACAP00000016663	ENSACAP00000002500	Fos proto-oncogene, AP-1 transcription factor subunit.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.432
FOS	EGR1	ENSACAP00000016663	ENSACAP00000020849	Fos proto-oncogene, AP-1 transcription factor subunit.	Early growth response 1.	0.847
FOS	FST	ENSACAP00000016663	ENSACAP00000015302	Fos proto-oncogene, AP-1 transcription factor subunit.	Follistatin.	0.459
FOS	SMAD4	ENSACAP00000016663	ENSACAP00000010054	Fos proto-oncogene, AP-1 transcription factor subunit.	Mothers against decapentaplegic homolog.	0.445
FOS	esr1	ENSACAP00000016663	ENSACAP00000006106	Fos proto-oncogene, AP-1 transcription factor subunit.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.847
FST	FOS	ENSACAP00000015302	ENSACAP00000016663	Follistatin.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.459
FST	NR5A1	ENSACAP00000015302	ENSACAP00000022961	Follistatin.	Nuclear receptor subfamily 5 group A member 1.	0.427
GRB2	FGFR1	ENSACAP00000006419	ENSACAP00000017732	Growth factor receptor bound protein 2.	Fibroblast growth factor receptor.	0.642
GRB2	esr1	ENSACAP00000006419	ENSACAP00000006106	Growth factor receptor bound protein 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.462
GRB2	ins	ENSACAP00000006419	ENSACAP00000009536	Growth factor receptor bound protein 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.670
NR5A1	FST	ENSACAP00000022961	ENSACAP00000015302	Nuclear receptor subfamily 5 group A member 1.	Follistatin.	0.427
NR5A1	esr1	ENSACAP00000022961	ENSACAP00000006106	Nuclear receptor subfamily 5 group A member 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.562