9 items (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (642 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (994 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1256 aa)
	CALR	Calreticulin. (419 aa)
	CANX	Calnexin. (607 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	LOC103282913	Uncharacterized protein. (140 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	LOC100557361	Calreticulin. (372 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALR	CANX	ENSACAP00000016882	ENSACAP00000016009	Calreticulin.	Calnexin.	0.782
CALR	LOC100557361	ENSACAP00000016882	ENSACAP00000019047	Calreticulin.	Calreticulin.	0.902
CALR	LOC103282913	ENSACAP00000016882	ENSACAP00000009098	Calreticulin.	Uncharacterized protein.	0.902
CANX	CALR	ENSACAP00000016009	ENSACAP00000016882	Calnexin.	Calreticulin.	0.782
CANX	LOC100557361	ENSACAP00000016009	ENSACAP00000019047	Calnexin.	Calreticulin.	0.783
CANX	LOC103282913	ENSACAP00000016009	ENSACAP00000009098	Calnexin.	Uncharacterized protein.	0.789
ERBB2	esr1	ENSACAP00000003644	ENSACAP00000006106	Receptor protein-tyrosine kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.639
ERBB2	ins	ENSACAP00000003644	ENSACAP00000009536	Receptor protein-tyrosine kinase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.748
IGF1R	esr1	ENSACAP00000008063	ENSACAP00000006106	Tyrosine-protein kinase receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.816
IGF1R	ins	ENSACAP00000008063	ENSACAP00000009536	Tyrosine-protein kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.991
LOC100557361	CALR	ENSACAP00000019047	ENSACAP00000016882	Calreticulin.	Calreticulin.	0.902
LOC100557361	CANX	ENSACAP00000019047	ENSACAP00000016009	Calreticulin.	Calnexin.	0.783
LOC100557361	LOC103282913	ENSACAP00000019047	ENSACAP00000009098	Calreticulin.	Uncharacterized protein.	0.902
LOC103282913	CALR	ENSACAP00000009098	ENSACAP00000016882	Uncharacterized protein.	Calreticulin.	0.902
LOC103282913	CANX	ENSACAP00000009098	ENSACAP00000016009	Uncharacterized protein.	Calnexin.	0.789
LOC103282913	LOC100557361	ENSACAP00000009098	ENSACAP00000019047	Uncharacterized protein.	Calreticulin.	0.902
esr1	ERBB2	ENSACAP00000006106	ENSACAP00000003644	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Receptor protein-tyrosine kinase.	0.639
esr1	IGF1R	ENSACAP00000006106	ENSACAP00000008063	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Tyrosine-protein kinase receptor.	0.816
esr1	ins	ENSACAP00000006106	ENSACAP00000009536	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.631
ins	ERBB2	ENSACAP00000009536	ENSACAP00000003644	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Receptor protein-tyrosine kinase.	0.748