STRINGSTRING
SCX SCX NOTCH3 NOTCH3 WNT9B WNT9B SEMA3D SEMA3D FGF4 FGF4 FGF19 FGF19 FGF7 FGF7 DHH DHH FGF12 FGF12 ALDH1A2 ALDH1A2 RBPJ RBPJ GLB1 GLB1 FGF1 FGF1 GLB1L GLB1L LOC100567617 LOC100567617 PTCH1 PTCH1 FGFR1 FGFR1 FGF8 FGF8 FGF2 FGF2 DACH1 DACH1 CXCR4 CXCR4 glb1l2 glb1l2 JAG1 JAG1 WT1 WT1 FGF9 FGF9 FGF14 FGF14 FGF11 FGF11 TBX18 TBX18 sod2 sod2 FGFR4 FGFR4 VEGFC VEGFC FGF20 FGF20 IGF1R IGF1R LOC100556426 LOC100556426 FGF16 FGF16 ANGPT2 ANGPT2 FGF6 FGF6 FGF5 FGF5 EGF EGF FGF10 FGF10 CXCL12 CXCL12 DUSP6 DUSP6 FGF3 FGF3 PDGFB PDGFB fgf21 fgf21 FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCXScleraxis bHLH transcription factor. (198 aa)
NOTCH3Notch receptor 3. (2391 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (679 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (494 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (515 aa)
GLB1Beta-galactosidase. (649 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GLB1LGalactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (644 aa)
LOC100567617Fibrinogen C-terminal domain-containing protein. (407 aa)
PTCH1Patched 1. (1047 aa)
FGFR1Fibroblast growth factor receptor. (821 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
DACH1Dachshund family transcription factor 1. (758 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (355 aa)
glb1l2Beta-galactosidase. (702 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1217 aa)
WT1WT1 transcription factor. (288 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (151 aa)
TBX18T-box transcription factor 18. (557 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
FGFR4Fibroblast growth factor receptor. (808 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
LOC100556426Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (109 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
ANGPT2Angiopoietin 2. (496 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (262 aa)
EGFEpidermal growth factor. (1049 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (136 aa)
CXCL12C-X-C motif chemokine ligand 12. (71 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (425 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (148 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (247 aa)
fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.