10 items (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100555670	Uncharacterized protein. (218 aa)
	ESR2	Estrogen receptor 2. (555 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	IGF2	Insulin like growth factor 2. (186 aa)
	ar	Androgen receptor. (232 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (642 aa)
	igf2r	Fibronectin type-II domain-containing protein. (2175 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR2	IGF1R	ENSACAP00000015597	ENSACAP00000008063	Estrogen receptor 2.	Tyrosine-protein kinase receptor.	0.555
ESR2	ar	ENSACAP00000015597	ENSACAP00000009410	Estrogen receptor 2.	Androgen receptor.	0.429
ESR2	esr1	ENSACAP00000015597	ENSACAP00000006106	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.944
GAPDH	YWHAZ	ENSACAP00000006417	ENSACAP00000008552	Glyceraldehyde-3-phosphate dehydrogenase.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.	0.563
GAPDH	ins	ENSACAP00000006417	ENSACAP00000009536	Glyceraldehyde-3-phosphate dehydrogenase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.467
IGF1R	ESR2	ENSACAP00000008063	ENSACAP00000015597	Tyrosine-protein kinase receptor.	Estrogen receptor 2.	0.555
IGF1R	IGF2	ENSACAP00000008063	ENSACAP00000009504	Tyrosine-protein kinase receptor.	Insulin like growth factor 2.	0.960
IGF1R	esr1	ENSACAP00000008063	ENSACAP00000006106	Tyrosine-protein kinase receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.816
IGF1R	igf2r	ENSACAP00000008063	ENSACAP00000004087	Tyrosine-protein kinase receptor.	Fibronectin type-II domain-containing protein.	0.539
IGF1R	ins	ENSACAP00000008063	ENSACAP00000009536	Tyrosine-protein kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.991
IGF2	IGF1R	ENSACAP00000009504	ENSACAP00000008063	Insulin like growth factor 2.	Tyrosine-protein kinase receptor.	0.960
IGF2	igf2r	ENSACAP00000009504	ENSACAP00000004087	Insulin like growth factor 2.	Fibronectin type-II domain-containing protein.	0.969
IGF2	ins	ENSACAP00000009504	ENSACAP00000009536	Insulin like growth factor 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.582
LOC100555670	ins	ENSACAP00000012732	ENSACAP00000009536	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.408
YWHAZ	GAPDH	ENSACAP00000008552	ENSACAP00000006417	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.563
ar	ESR2	ENSACAP00000009410	ENSACAP00000015597	Androgen receptor.	Estrogen receptor 2.	0.429
ar	esr1	ENSACAP00000009410	ENSACAP00000006106	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.722
esr1	ESR2	ENSACAP00000006106	ENSACAP00000015597	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Estrogen receptor 2.	0.944
esr1	IGF1R	ENSACAP00000006106	ENSACAP00000008063	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Tyrosine-protein kinase receptor.	0.816
esr1	ar	ENSACAP00000006106	ENSACAP00000009410	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	Androgen receptor.	0.722