32 items (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLEK	Pleckstrin. (358 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (891 aa)
	irak4	Interleukin 1 receptor associated kinase 4. (498 aa)
	IRS1	Insulin receptor substrate 1. (1168 aa)
	JAK2	Tyrosine-protein kinase. (1129 aa)
	ANGPTL2	Angiopoietin like 2. (449 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (548 aa)
	PLEK2	Pleckstrin 2. (355 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (642 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	BCL6	BCL6 transcription repressor. (619 aa)
	CRK	CRK proto-oncogene, adaptor protein. (228 aa)
	IGF2	Insulin like growth factor 2. (186 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1283 aa)
	CXCL12	C-X-C motif chemokine ligand 12. (71 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	SRC	Tyrosine-protein kinase. (532 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (679 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (513 aa)
	LOC100554079	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (218 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
	NEK7	NIMA related kinase 7; Belongs to the protein kinase superfamily. (306 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (692 aa)
	ESR2	Estrogen receptor 2. (555 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	SOCS3	Suppressor of cytokine signaling 3. (211 aa)
	STAT3	Signal transducer and activator of transcription. (773 aa)
	tlr2	TIR domain-containing protein. (775 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	cd19	Ig-like domain-containing protein. (515 aa)
	IL6	Interleukin 6. (211 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CCR7	ENSACAP00000006553	ENSACAP00000015840	BCL6 transcription repressor.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.403
BCL6	STAT3	ENSACAP00000006553	ENSACAP00000017673	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.420
BCL6	cd19	ENSACAP00000006553	ENSACAP00000022285	BCL6 transcription repressor.	Ig-like domain-containing protein.	0.549
CCR7	BCL6	ENSACAP00000015840	ENSACAP00000006553	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	BCL6 transcription repressor.	0.403
CCR7	CXCL12	ENSACAP00000015840	ENSACAP00000011494	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12.	0.916
CCR7	CXCR3	ENSACAP00000015840	ENSACAP00000020224	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.404
CCR7	IL6	ENSACAP00000015840	ENSACAP00000023010	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin 6.	0.602
CCR7	cd19	ENSACAP00000015840	ENSACAP00000022285	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Ig-like domain-containing protein.	0.611
CRK	FYN	ENSACAP00000008212	ENSACAP00000011520	CRK proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.436
CRK	GRB2	ENSACAP00000008212	ENSACAP00000006419	CRK proto-oncogene, adaptor protein.	Growth factor receptor bound protein 2.	0.880
CRK	IRS1	ENSACAP00000008212	ENSACAP00000003729	CRK proto-oncogene, adaptor protein.	Insulin receptor substrate 1.	0.473
CRK	SRC	ENSACAP00000008212	ENSACAP00000011762	CRK proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.729
CXCL12	CCR7	ENSACAP00000011494	ENSACAP00000015840	C-X-C motif chemokine ligand 12.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.916
CXCL12	CXCR3	ENSACAP00000011494	ENSACAP00000020224	C-X-C motif chemokine ligand 12.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.859
CXCL12	IL6	ENSACAP00000011494	ENSACAP00000023010	C-X-C motif chemokine ligand 12.	Interleukin 6.	0.557
CXCL12	TLR4	ENSACAP00000011494	ENSACAP00000013654	C-X-C motif chemokine ligand 12.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.460
CXCL12	esr1	ENSACAP00000011494	ENSACAP00000006106	C-X-C motif chemokine ligand 12.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.467
CXCR3	CCR7	ENSACAP00000020224	ENSACAP00000015840	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.404
CXCR3	CXCL12	ENSACAP00000020224	ENSACAP00000011494	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12.	0.859
ESR2	SRC	ENSACAP00000015597	ENSACAP00000011762	Estrogen receptor 2.	Tyrosine-protein kinase.	0.673