(44 nodes) Glutathione metabolism network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RRM2	Ribonucleotide reductase regulatory subunit M2. (391 aa)
	SRM	Spermidine synthase; Belongs to the spermidine/spermine synthase family. (300 aa)
	ggct	Uncharacterized protein. (198 aa)
	GSR	Glutathione-disulfide reductase. (464 aa)
	ggt1	Uncharacterized protein. (572 aa)
	ggt5	Uncharacterized protein. (571 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (224 aa)
	LOC100565219	Uncharacterized protein. (211 aa)
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (242 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	MGST3	Microsomal glutathione S-transferase 3. (143 aa)
	GSTK1	Glutathione S-transferase kappa. (246 aa)
	oplah	Uncharacterized protein. (479 aa)
	gpx4	Uncharacterized protein. (93 aa)
	GSS	Glutathione synthetase. (474 aa)
	txndc12	Thioredoxin domain-containing protein. (168 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (155 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (637 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (344 aa)
	LOC100553289	Uncharacterized protein. (221 aa)
	LOC100559708	Uncharacterized protein. (223 aa)
	LOC103282135	Uncharacterized protein. (530 aa)
	LOC100557138	Uncharacterized protein; Belongs to the GST superfamily. (255 aa)
	GGT7	Gamma-glutamyltransferase 7. (676 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (449 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa)
	LAP3	Leucine aminopeptidase 3. (401 aa)
	LOC100554103	Uncharacterized protein; Belongs to the GST superfamily. (220 aa)
	GSTM4	GST C-terminal domain-containing protein. (101 aa)
	GSTM3	Glutathione S-transferase mu 3. (220 aa)
	CHAC2	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (281 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (548 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (493 aa)
	LOC100556942	Uncharacterized protein; Belongs to the GST superfamily. (242 aa)
	MGST1	Microsomal glutathione S-transferase 1. (156 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (207 aa)
	PRDX6	Peroxiredoxin 6. (224 aa)
	H9GNB7_ANOCA	N-acetyltransferase domain-containing protein. (239 aa)
	sms	PABS domain-containing protein. (365 aa)
	LOC100553097	Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
	LOC100566062	N-acetyltransferase domain-containing protein. (220 aa)
	LOC100553624	Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
	LOC100561816	Uncharacterized protein. (357 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHAC1	CHAC2	ENSACAP00000003416	ENSACAP00000012289	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.905
CHAC1	GGT7	ENSACAP00000003416	ENSACAP00000009415	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamyltransferase 7.	0.907
CHAC1	GPX1	ENSACAP00000003416	ENSACAP00000008114	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.902
CHAC1	GPX7	ENSACAP00000003416	ENSACAP00000008132	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.909
CHAC1	GPX8	ENSACAP00000003416	ENSACAP00000015133	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.906
CHAC1	GSR	ENSACAP00000003416	ENSACAP00000003290	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione-disulfide reductase.	0.900
CHAC1	GSS	ENSACAP00000003416	ENSACAP00000007320	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione synthetase.	0.910
CHAC1	GSTK1	ENSACAP00000003416	ENSACAP00000006723	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase kappa.	0.650
CHAC1	GSTM3	ENSACAP00000003416	ENSACAP00000011712	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase mu 3.	0.650
CHAC1	GSTM4	ENSACAP00000003416	ENSACAP00000011500	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	GST C-terminal domain-containing protein.	0.650
CHAC1	GSTO1	ENSACAP00000003416	ENSACAP00000005091	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase omega 1; Belongs to the GST superfamily.	0.779
CHAC1	LAP3	ENSACAP00000003416	ENSACAP00000010958	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Leucine aminopeptidase 3.	0.905
CHAC1	LOC100553097	ENSACAP00000003416	ENSACAP00000017900	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.650
CHAC1	LOC100553289	ENSACAP00000003416	ENSACAP00000008814	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.650
CHAC1	LOC100553624	ENSACAP00000003416	ENSACAP00000022240	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.650
CHAC1	LOC100554103	ENSACAP00000003416	ENSACAP00000011495	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.650
CHAC1	LOC100556942	ENSACAP00000003416	ENSACAP00000013051	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.650
CHAC1	LOC100557138	ENSACAP00000003416	ENSACAP00000009145	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.650
CHAC1	LOC100559708	ENSACAP00000003416	ENSACAP00000008839	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.650
CHAC1	LOC100561816	ENSACAP00000003416	ENSACAP00000022720	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.907