STRINGSTRING
WNT5B WNT5B LPIN1 LPIN1 map2k2 map2k2 MTOR MTOR DDIT4 DDIT4 PRKCA PRKCA STRADB STRADB MAPK1 MAPK1 ATP6V1B2 ATP6V1B2 SOS2 SOS2 RHEB RHEB CAB39 CAB39 FZD4 FZD4 depdc5 depdc5 L7MZJ0_ANOCA L7MZJ0_ANOCA AKT2 AKT2 NRAS NRAS PIK3CB PIK3CB PDPK1 PDPK1 MAPKAP1 MAPKAP1 ATP6V1G1 ATP6V1G1 IRS1 IRS1 TSC1 TSC1 TBC1D7 TBC1D7 LRP6 LRP6 PIK3CA PIK3CA FZD7 FZD7 WNT9A WNT9A LOC100555207 LOC100555207 SOS1 SOS1 GRB2 GRB2 AKT3 AKT3 ATP6V1A ATP6V1A PRKAA2 PRKAA2 wnt3a wnt3a NPRL2 NPRL2 WNT16 WNT16 EIF4E1B EIF4E1B ULK1 ULK1 WNT1 WNT1 WNT10B WNT10B IGF1R IGF1R RHOA RHOA RPS6KB2 RPS6KB2 GRB10 GRB10 TSC2 TSC2 DEPTOR DEPTOR SKP2 SKP2 LPIN2 LPIN2 ATP6V1C1 ATP6V1C1 FZD6 FZD6 ins ins LOC100558982 LOC100558982 LOC100556214 LOC100556214 RICTOR RICTOR PRKAA1 PRKAA1 SGK1 SGK1 Pik3r2 Pik3r2 DVL3 DVL3 NPRL3 NPRL3 FZD3 FZD3 EIF4E2 EIF4E2 WNT8B WNT8B SESN2 SESN2 BRAF BRAF LOC100554463 LOC100554463 RNF152 RNF152 AKT1 AKT1 WDR24 WDR24 EIF4B EIF4B LOC100567364 LOC100567364 CHUK CHUK atp6v1g2 atp6v1g2 FNIP1 FNIP1 LAMTOR3 LAMTOR3 STRADA STRADA atp6v1e1 atp6v1e1 FZD2 FZD2 WNT4 WNT4 WNT7A WNT7A WNT10A WNT10A LAMTOR5 LAMTOR5 IKBKB IKBKB ATP6V1C2 ATP6V1C2 RPS6KA3 RPS6KA3 LOC100553094 LOC100553094 rps6kb1 rps6kb1 MIOS MIOS TTI1 TTI1 SEH1L SEH1L PIK3CD PIK3CD MLST8 MLST8 DVL1 DVL1 STK11 STK11 EIF4E EIF4E FZD10 FZD10 WNT6 WNT6 WNT7B WNT7B LAMTOR1 LAMTOR1 RRAGD RRAGD lrp5 lrp5 TELO2 TELO2 SEC13 SEC13 HRAS HRAS SLC38A9 SLC38A9 MAPK3 MAPK3 PTEN PTEN RPS6KA2 RPS6KA2 rptor rptor FZD1 FZD1 pik3r3 pik3r3 PIK3R1 PIK3R1 FNIP2 FNIP2 PRKCG PRKCG IGF1 IGF1 rps6ka1 rps6ka1 WNT3 WNT3 WNT9B WNT9B KRAS KRAS WNT8A WNT8A LOC100559807 LOC100559807 WNT5A WNT5A rps6 rps6 WNT2B WNT2B ATP6V1H ATP6V1H LOC100561101 LOC100561101 RAF1 RAF1 EIF4EBP1 EIF4EBP1 ATP6V1G3 ATP6V1G3 LOC103278072 LOC103278072 WDR59 WDR59
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
LPIN1Lipin 1. (937 aa)
map2k2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
MTORSerine/threonine-protein kinase TOR. (2314 aa)
DDIT4DNA damage inducible transcript 4. (220 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (626 aa)
STRADBSTE20 related adaptor beta. (434 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (508 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1282 aa)
RHEBRas homolog, mTORC1 binding. (198 aa)
CAB39Calcium binding protein 39. (341 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (526 aa)
depdc5Uncharacterized protein. (891 aa)
L7MZJ0_ANOCAATP-synt_ab domain-containing protein. (38 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NRASNRAS proto-oncogene, GTPase. (194 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (546 aa)
MAPKAP1MAPK associated protein 1. (511 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
IRS1Insulin receptor substrate 1. (1168 aa)
TSC1TSC complex subunit 1. (1234 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
LOC100555207Uncharacterized protein. (398 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1340 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
PRKAA2Non-specific serine/threonine protein kinase. (565 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (290 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (187 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1031 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
RHOARas homolog family member A. (193 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (528 aa)
GRB10Growth factor receptor bound protein 10. (586 aa)
TSC2TSC complex subunit 2. (1291 aa)
DEPTORDEP domain containing MTOR interacting protein. (398 aa)
SKP2S-phase kinase associated protein 2. (422 aa)
LPIN2Lipin 2. (891 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
LOC100558982Protein kinase domain-containing protein. (173 aa)
LOC100556214Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1731 aa)
PRKAA1Non-specific serine/threonine protein kinase. (550 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
Pik3r2Uncharacterized protein. (215 aa)
DVL3Dishevelled segment polarity protein 3. (715 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (566 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (258 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SESN2Uncharacterized protein. (499 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (807 aa)
LOC100554463Uncharacterized protein. (529 aa)
RNF152Ring finger protein 152. (203 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
WDR24WD repeat domain 24. (345 aa)
EIF4BEukaryotic translation initiation factor 4B. (632 aa)
LOC100567364Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1072 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (679 aa)
atp6v1g2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FNIP1Folliculin interacting protein 1. (1145 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
STRADASTE20 related adaptor alpha. (431 aa)
atp6v1e1Uncharacterized protein. (226 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (252 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (88 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (761 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (395 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (711 aa)
LOC100553094Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (349 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
MIOSMeiosis regulator for oocyte development. (881 aa)
TTI1TELO2 interacting protein 1. (1073 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (324 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1047 aa)
MLST8MTOR associated protein, LST8 homolog. (387 aa)
DVL1Dishevelled segment polarity protein 1. (653 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (447 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
RRAGDRas related GTP binding D. (414 aa)
lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1627 aa)
TELO2Telomere maintenance 2. (690 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (363 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SLC38A9Solute carrier family 38 member 9. (558 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
rptorRaptor_N domain-containing protein. (725 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (568 aa)
pik3r3Uncharacterized protein. (473 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FNIP2Folliculin interacting protein 2. (1088 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
IGF1Insulin like growth factor 1. (166 aa)
rps6ka1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (468 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC100559807Uncharacterized protein. (186 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (476 aa)
LOC100561101TNF_2 domain-containing protein. (234 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (649 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (114 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (84 aa)
LOC103278072TNF_2 domain-containing protein. (239 aa)
WDR59WD repeat domain 59. (989 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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