100 items (Anolis carolinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADRA1D	Adrenoceptor alpha 1D; Belongs to the G-protein coupled receptor 1 family. (512 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
	AVPR1A	Arginine vasopressin receptor 1A. (408 aa)
	map2k2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	ACTA2	Actin alpha 2, smooth muscle. (377 aa)
	gnas	Uncharacterized protein. (379 aa)
	CALCRL	Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (626 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (463 aa)
	actg2	Uncharacterized protein. (376 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	PLA2G4A	Phospholipase A2. (743 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1202 aa)
	PLA2G1B	Phospholipase A(2). (152 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1147 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (393 aa)
	LOC100568079	Phospholipase A(2). (149 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1527 aa)
	Edn3	END domain-containing protein. (74 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (411 aa)
	PPP1R14A	Protein phosphatase 1 regulatory inhibitor subunit 14A. (155 aa)
	PRKCE	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (740 aa)
	LOC100565491	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (777 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	Kcnmb2	Uncharacterized protein. (96 aa)
	gnaq	Uncharacterized protein. (359 aa)
	ADRA1A	Adrenoceptor alpha 1A. (464 aa)
	prkch	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (579 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	RAMP3	Receptor activity modifying protein 3. (147 aa)
	MYL6	Uncharacterized protein. (151 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
	RHOA	Ras homolog family member A. (193 aa)
	EDN1	Endothelin 1. (209 aa)
	PTGIR	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (292 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1160 aa)
	LOC100563268	Uncharacterized protein. (382 aa)
	MRVI1	Murine retrovirus integration site 1 homolog. (830 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	myl9	Uncharacterized protein. (172 aa)
	LOC100558982	Protein kinase domain-containing protein. (173 aa)
	Prkaca	Uncharacterized protein. (172 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1843 aa)
	LOC100568171	Phospholipase A(2). (124 aa)
	pla2g3	PA2c domain-containing protein. (155 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1122 aa)
	CALML4	Calmodulin like 4. (155 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2695 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1227 aa)
	MYLK	Myosin light chain kinase. (1976 aa)
	LOC100551783	Phospholipase A(2). (111 aa)
	adcy5	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (794 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (754 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (657 aa)
	MYLK2	Myosin light chain kinase 2. (197 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (807 aa)
	Cacna1d	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1136 aa)
	CALD1	Caldesmon 1. (852 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	CALCB	Calcitonin related polypeptide beta. (140 aa)
	PLA2G12A	Phospholipase A2 group XIIA. (198 aa)
	LOC103282130	PA2c domain-containing protein. (151 aa)
	PPP1R12A	Protein phosphatase 1 regulatory subunit. (1062 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1092 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1213 aa)
	RAMP2	Receptor activity modifying protein 2. (119 aa)
	JMJD7	Jumonji domain containing 7. (318 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	PLA2G4F	Phospholipase A2. (865 aa)
	MYH14	Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2021 aa)
	RAMP1	Receptor activity modifying protein 1. (143 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2659 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
	PPP1R12C	Protein phosphatase 1 regulatory subunit. (843 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (687 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2118 aa)
	GNA11	G protein subunit alpha 11. (200 aa)
	KCNMB4	Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (223 aa)
	G1KWG5_ANOCA	PA2c domain-containing protein. (28 aa)
	LOC103282196	Uncharacterized protein. (232 aa)
	MYL6B	Uncharacterized protein. (203 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (649 aa)
	nppc	Uncharacterized protein. (171 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (227 aa)
	LOC100560615	PLA2c domain-containing protein. (568 aa)
	KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (205 aa)
	LOC100567537	PLA2c domain-containing protein. (561 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)
	LOC103278097	Uncharacterized protein. (382 aa)
	LOC100567732	PLA2c domain-containing protein. (599 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	MYH10	ENSACAP00000000525	ENSACAP00000017391	Actin alpha 2, smooth muscle.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.930
ACTA2	MYH14	ENSACAP00000000525	ENSACAP00000015348	Actin alpha 2, smooth muscle.	Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.941
ACTA2	MYH9	ENSACAP00000000525	ENSACAP00000016238	Actin alpha 2, smooth muscle.	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.930
ACTA2	MYL6	ENSACAP00000000525	ENSACAP00000007748	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.939
ACTA2	MYL6B	ENSACAP00000000525	ENSACAP00000021421	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.938
ACTA2	MYLK	ENSACAP00000000525	ENSACAP00000010518	Actin alpha 2, smooth muscle.	Myosin light chain kinase.	0.450
ACTA2	PPP1CA	ENSACAP00000000525	ENSACAP00000007971	Actin alpha 2, smooth muscle.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.436
ACTA2	PPP1CB	ENSACAP00000000525	ENSACAP00000009234	Actin alpha 2, smooth muscle.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.439
ACTA2	PPP1CC	ENSACAP00000000525	ENSACAP00000002077	Actin alpha 2, smooth muscle.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.429
ACTA2	actg2	ENSACAP00000000525	ENSACAP00000001688	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.900
ACTA2	myl9	ENSACAP00000000525	ENSACAP00000009517	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.938
ADCY1	ADCY2	ENSACAP00000007882	ENSACAP00000009989	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.456
ADCY1	ADCY4	ENSACAP00000007882	ENSACAP00000009399	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.463
ADCY1	ADCY6	ENSACAP00000007882	ENSACAP00000008442	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.442
ADCY1	ADCY7	ENSACAP00000007882	ENSACAP00000013999	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.469
ADCY1	ADCY8	ENSACAP00000007882	ENSACAP00000010472	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.955
ADCY1	ADCY9	ENSACAP00000007882	ENSACAP00000016127	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.668
ADCY1	CALM2	ENSACAP00000007882	ENSACAP00000004388	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.954
ADCY1	CALML4	ENSACAP00000007882	ENSACAP00000010061	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.942
ADCY1	LOC100563268	ENSACAP00000007882	ENSACAP00000008459	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.960