STRINGSTRING
ROCK2 ROCK2 PDGFA PDGFA VWF VWF LAMA3 LAMA3 MYL5 MYL5 PRKCA PRKCA VAV3 VAV3 PIP5K1B PIP5K1B MAPK1 MAPK1 SOS2 SOS2 VEGFA VEGFA ITGAV ITGAV pak1 pak1 PPP1CC PPP1CC PAK5 PAK5 MYL2 MYL2 LOC100562030 LOC100562030 LOC100561835 LOC100561835 FLNB FLNB ARHGAP5 ARHGAP5 AKT2 AKT2 THBS2 THBS2 CCND3 CCND3 PIK3CB PIK3CB PDPK1 PDPK1 CAPN2 CAPN2 ERBB2 ERBB2 COL4A4 COL4A4 ITGA2 ITGA2 ITGA1 ITGA1 COL4A3 COL4A3 COL6A3 COL6A3 CTNNB1 CTNNB1 LAMB1 LAMB1 LAMB4 LAMB4 PARVA PARVA COL6A1 COL6A1 COL6A2 COL6A2 COL9A2 COL9A2 PIK3CA PIK3CA chad chad LAMC1 LAMC1 COL1A1 COL1A1 LAMC2 LAMC2 col9a3 col9a3 ACTN1 ACTN1 itga3 itga3 LAMB3 LAMB3 VEGFC VEGFC SHC4 SHC4 COL2A1 COL2A1 SOS1 SOS1 GRB2 GRB2 CAV1 CAV1 CAV2 CAV2 AKT3 AKT3 RELN RELN ITGB7 ITGB7 ITGB1 ITGB1 JUN JUN ZYX ZYX ITGB4 ITGB4 DOCK1 DOCK1 ILK ILK PPP1CA PPP1CA TLN2 TLN2 ROCK1 ROCK1 IGF1R IGF1R RHOA RHOA col9a1 col9a1 CRK CRK MET MET ITGA4 ITGA4 PPP1CB PPP1CB LOC100565496 LOC100565496 flnc flnc FLT1 FLT1 myl9 myl9 LOC100558982 LOC100558982 itga9 itga9 LAMA1 LAMA1 FLNA FLNA RAC3 RAC3 ITGA7 ITGA7 ITGB5 ITGB5 actn4 actn4 Pik3r2 Pik3r2 pdgfra pdgfra MYLK MYLK MYLK2 MYLK2 BRAF BRAF TLN1 TLN1 XIAP XIAP MAPK8 MAPK8 ITGA5 ITGA5 AKT1 AKT1 ARHGAP35 ARHGAP35 ITGB8 ITGB8 LOC100562999 LOC100562999 PDGFD PDGFD CAV3 CAV3 PAK4 PAK4 vtn vtn SRC SRC MAPK10 MAPK10 LOC100567364 LOC100567364 LOC100556625 LOC100556625 DIAPH1 DIAPH1 COL4A6 COL4A6 ITGB6 ITGB6 VEGFD VEGFD CDC42 CDC42 COL4A5 COL4A5 IBSP IBSP shc2 shc2 birc2 birc2 RAC1 RAC1 PAK3 PAK3 HGF HGF PIK3CD PIK3CD COL1A2 COL1A2 Lama2 Lama2 PPP1R12A PPP1R12A COL4A2 COL4A2 PAK6 PAK6 comp comp LOC100566319 LOC100566319 PIP5K1A PIP5K1A HRAS HRAS LOC100563069 LOC100563069 TNR TNR MAPK3 MAPK3 PTEN PTEN actg1 actg1 MYL10 MYL10 PDGFRB PDGFRB PARVG PARVG FN1 FN1 pik3r3 pik3r3 FLT4 FLT4 CCND1 CCND1 RAC2 RAC2 PIK3R1 PIK3R1 PRKCG PRKCG IGF1 IGF1 ITGA8 ITGA8 thbs4 thbs4 MAPK9 MAPK9 PGF PGF itgb3 itgb3 PDGFC PDGFC PPP1R12C PPP1R12C EGFR EGFR LOC100560886 LOC100560886 PARVB PARVB rap1a rap1a RAF1 RAF1 RAP1B RAP1B PDGFB PDGFB LOC100563056 LOC100563056 PTK2 PTK2 thbs1 thbs1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (197 aa)
VWFVon Willebrand factor. (2807 aa)
LAMA3Laminin subunit alpha 3. (3414 aa)
MYL5Myosin light chain 5. (172 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (626 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (551 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1282 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1041 aa)
pak1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
PAK5Non-specific serine/threonine protein kinase. (751 aa)
MYL2Myosin light chain 2. (165 aa)
LOC100562030Uncharacterized protein. (2214 aa)
LOC100561835Uncharacterized protein. (2230 aa)
FLNBFilamin B. (2545 aa)
ARHGAP5Rho GTPase activating protein 5. (1505 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
THBS2Thrombospondin 2. (1179 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (293 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (546 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1187 aa)
COL4A3Collagen type IV alpha 3 chain. (1682 aa)
COL6A3Collagen type VI alpha 3 chain. (3151 aa)
CTNNB1Catenin beta 1. (781 aa)
LAMB1Laminin subunit beta 1. (1755 aa)
LAMB4Laminin subunit beta 4. (1698 aa)
PARVAParvin alpha. (372 aa)
COL6A1Collagen type VI alpha 1 chain. (1012 aa)
COL6A2Collagen type VI alpha 2 chain. (1024 aa)
COL9A2Collagen type IX alpha 2 chain. (475 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
chadUncharacterized protein. (361 aa)
LAMC1Laminin subunit gamma 1. (1614 aa)
COL1A1Collagen type I alpha 1 chain. (1488 aa)
LAMC2Laminin subunit gamma 2. (1173 aa)
col9a3Uncharacterized protein. (679 aa)
ACTN1Actinin alpha 1. (893 aa)
itga3Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1053 aa)
LAMB3Laminin subunit beta 3. (1112 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
SHC4SHC adaptor protein 4. (617 aa)
COL2A1Collagen type II alpha 1 chain. (1460 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1340 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RELNReelin. (3312 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (791 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)
ZYXZyxin. (621 aa)
ITGB4Integrin beta. (1794 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1859 aa)
ILKIntegrin linked kinase. (321 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
TLN2Uncharacterized protein. (2256 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
RHOARas homolog family member A. (193 aa)
col9a1LAM_G_DOMAIN domain-containing protein. (663 aa)
CRKCRK proto-oncogene, adaptor protein. (228 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1383 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1040 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC100565496Uncharacterized protein. (172 aa)
flncUncharacterized protein. (1203 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1334 aa)
myl9Uncharacterized protein. (172 aa)
LOC100558982Protein kinase domain-containing protein. (173 aa)
itga9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1029 aa)
LAMA1Laminin subunit alpha 1. (3149 aa)
FLNAFilamin A. (2702 aa)
RAC3Rac family small GTPase 3. (180 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1076 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
actn4Uncharacterized protein. (927 aa)
Pik3r2Uncharacterized protein. (215 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
MYLKMyosin light chain kinase. (1976 aa)
MYLK2Myosin light chain kinase 2. (197 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (807 aa)
TLN1Talin 1. (2356 aa)
XIAPX-linked inhibitor of apoptosis. (568 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1032 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ARHGAP35Rho GTPase activating protein 35. (1504 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (739 aa)
LOC100562999Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
PDGFDPlatelet derived growth factor D. (432 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (157 aa)
PAK4Non-specific serine/threonine protein kinase. (709 aa)
vtnSMB domain-containing protein. (449 aa)
SRCTyrosine-protein kinase. (532 aa)
MAPK10Mitogen-activated protein kinase. (442 aa)
LOC100567364Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1072 aa)
LOC100556625Uncharacterized protein. (934 aa)
DIAPH1Diaphanous related formin 1. (1082 aa)
COL4A6Collagen type IV alpha 6 chain. (1710 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
CDC42Uncharacterized protein. (80 aa)
COL4A5Collagen type IV alpha 5 chain. (1637 aa)
IBSPIntegrin binding sialoprotein. (322 aa)
shc2Uncharacterized protein. (589 aa)
birc2Uncharacterized protein. (603 aa)
RAC1Rac family small GTPase 1. (192 aa)
PAK3Non-specific serine/threonine protein kinase. (557 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1047 aa)
COL1A2Collagen type I alpha 2 chain. (1340 aa)
Lama2Uncharacterized protein. (1860 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1062 aa)
COL4A2Collagen type IV alpha 2 chain. (1624 aa)
PAK6Non-specific serine/threonine protein kinase. (670 aa)
compUncharacterized protein. (697 aa)
LOC100566319Uncharacterized protein. (254 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (490 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC100563069Uncharacterized protein. (1868 aa)
TNRTenascin R. (1360 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
actg1Actin gamma 1. (374 aa)
MYL10Myosin light chain 10. (167 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1075 aa)
PARVGParvin gamma. (322 aa)
FN1Fibronectin 1. (2444 aa)
pik3r3Uncharacterized protein. (473 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1384 aa)
CCND1Cyclin D1. (154 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
IGF1Insulin like growth factor 1. (166 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1083 aa)
thbs4Uncharacterized protein. (936 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (157 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (585 aa)
PDGFCPlatelet derived growth factor C. (340 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (843 aa)
EGFRReceptor protein-tyrosine kinase. (1185 aa)
LOC100560886Uncharacterized protein. (108 aa)
PARVBParvin beta. (367 aa)
rap1aUncharacterized protein. (184 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (649 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (247 aa)
LOC100563056Protein kinase domain-containing protein. (347 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)
thbs1Uncharacterized protein. (179 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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