STRINGSTRING
ROCK2 ROCK2 map2k2 map2k2 PDGFA PDGFA CXCR4 CXCR4 LPAR4 LPAR4 ARPC2 ARPC2 LPAR1 LPAR1 MYL5 MYL5 RDX RDX VAV3 VAV3 PIP5K1B PIP5K1B MAPK1 MAPK1 FGD3 FGD3 SOS2 SOS2 ITGAV ITGAV GNA13 GNA13 PFN3 PFN3 pak1 pak1 PPP1CC PPP1CC PAK5 PAK5 MYL2 MYL2 CFL2 CFL2 FGF9 FGF9 NCKAP1 NCKAP1 NRAS NRAS PIK3CB PIK3CB spata13 spata13 ARHGEF12 ARHGEF12 CHRM3 CHRM3 CYFIP2 CYFIP2 IQGAP1 IQGAP1 MSN MSN f2 f2 MRAS MRAS ITGA2 ITGA2 CHRM4 CHRM4 ITGA1 ITGA1 EZR EZR LPAR2 LPAR2 ARHGEF4 ARHGEF4 PIK3CA PIK3CA ACTN1 ACTN1 FGFR4 FGFR4 itga3 itga3 FGF20 FGF20 LPAR5 LPAR5 SOS1 SOS1 itgam itgam ITGB7 ITGB7 ITGB1 ITGB1 PIP4K2C PIP4K2C ITGB4 ITGB4 DOCK1 DOCK1 LIMK1 LIMK1 apc apc PFN2 PFN2 F2R F2R PPP1CA PPP1CA ROCK1 ROCK1 IQGAP2 IQGAP2 RHOA RHOA CRK CRK LOC100556160 LOC100556160 FGF16 FGF16 PIP4K2A PIP4K2A ITGA4 ITGA4 PPP1CB PPP1CB FGF23 FGF23 FGF6 FGF6 ARHGEF6 ARHGEF6 LOC100565496 LOC100565496 ITGB2 ITGB2 myl9 myl9 ins ins LOC100558982 LOC100558982 itga9 itga9 ARPC4 ARPC4 PIKFYVE PIKFYVE RAC3 RAC3 ITGA7 ITGA7 ITGB5 ITGB5 actn4 actn4 Pik3r2 Pik3r2 pdgfra pdgfra MYLK MYLK WASF1 WASF1 FGF10 FGF10 ARAF ARAF MYLK2 MYLK2 ITGAL ITGAL SSH1 SSH1 BRAF BRAF ITGA5 ITGA5 ARHGAP35 ARHGAP35 CXCL12 CXCL12 ITGB8 ITGB8 PDGFD PDGFD FGF2 FGF2 FGF8 FGF8 PAK4 PAK4 SRC SRC LOC100567364 LOC100567364 CHRM2 CHRM2 SSH2 SSH2 DIAPH1 DIAPH1 ITGB6 ITGB6 RRAS2 RRAS2 CDC42 CDC42 FGD1 FGD1 RAC1 RAC1 PAK3 PAK3 PIP4K2B PIP4K2B BDKRB2 BDKRB2 PIK3CD PIK3CD FGF1 FGF1 SCIN SCIN RRAS RRAS PPP1R12A PPP1R12A PAK6 PAK6 Nckap1l Nckap1l LOC100566319 LOC100566319 PIP5K1A PIP5K1A HRAS HRAS MAPK3 MAPK3 LOC100555639 LOC100555639 actg1 actg1 MYL10 MYL10 INSRR INSRR PDGFRB PDGFRB MYH14 MYH14 FGF7 FGF7 FN1 FN1 pik3r3 pik3r3 ARPC3 ARPC3 FGF19 FGF19 FGF4 FGF4 RAC2 RAC2 PIK3R1 PIK3R1 MYH9 MYH9 ITGA8 ITGA8 LOC100560478 LOC100560478 itgb3 itgb3 PDGFC PDGFC PPP1R12C PPP1R12C KRAS KRAS LOC100559807 LOC100559807 EGFR EGFR APC2 APC2 MYH10 MYH10 WASF2 WASF2 MOS MOS tmsb4x tmsb4x FGF3 FGF3 FGF18 FGF18 TIAM1 TIAM1 CHRM5 CHRM5 RAF1 RAF1 WASL WASL fgf21 fgf21 FGFR2 FGFR2 PDGFB PDGFB PTK2 PTK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
map2k2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (197 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (355 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (396 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MYL5Myosin light chain 5. (172 aa)
RDXRadixin. (600 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (551 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (677 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1282 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1041 aa)
GNA13G protein subunit alpha 13. (377 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
pak1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
PAK5Non-specific serine/threonine protein kinase. (751 aa)
MYL2Myosin light chain 2. (165 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
NCKAP1NCK associated protein 1. (1128 aa)
NRASNRAS proto-oncogene, GTPase. (194 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
spata13Uncharacterized protein. (1266 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1527 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (603 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1922 aa)
MSNMoesin. (578 aa)
f2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (612 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (497 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1187 aa)
EZREzrin. (586 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (344 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (587 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ACTN1Actinin alpha 1. (893 aa)
FGFR4Fibroblast growth factor receptor. (808 aa)
itga3Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1053 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (340 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1340 aa)
itgamVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1168 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (791 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (410 aa)
ITGB4Integrin beta. (1794 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1859 aa)
LIMK1LIM domain kinase 1. (557 aa)
apcUncharacterized protein. (2772 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (386 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1631 aa)
RHOARas homolog family member A. (193 aa)
CRKCRK proto-oncogene, adaptor protein. (228 aa)
LOC100556160G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (326 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (404 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1040 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (188 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (777 aa)
LOC100565496Uncharacterized protein. (172 aa)
ITGB2Integrin beta. (767 aa)
myl9Uncharacterized protein. (172 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
LOC100558982Protein kinase domain-containing protein. (173 aa)
itga9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1029 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2125 aa)
RAC3Rac family small GTPase 3. (180 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1076 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
actn4Uncharacterized protein. (927 aa)
Pik3r2Uncharacterized protein. (215 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
MYLKMyosin light chain kinase. (1976 aa)
WASF1WASP family member 1. (548 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (136 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (657 aa)
MYLK2Myosin light chain kinase 2. (197 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1176 aa)
SSH1Slingshot protein phosphatase 1. (830 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (807 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1032 aa)
ARHGAP35Rho GTPase activating protein 35. (1504 aa)
CXCL12C-X-C motif chemokine ligand 12. (71 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (739 aa)
PDGFDPlatelet derived growth factor D. (432 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PAK4Non-specific serine/threonine protein kinase. (709 aa)
SRCTyrosine-protein kinase. (532 aa)
LOC100567364Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1072 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (463 aa)
SSH2Slingshot protein phosphatase 2. (1361 aa)
DIAPH1Diaphanous related formin 1. (1082 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
RRAS2RAS related 2. (203 aa)
CDC42Uncharacterized protein. (80 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (922 aa)
RAC1Rac family small GTPase 1. (192 aa)
PAK3Non-specific serine/threonine protein kinase. (557 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (422 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (389 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1047 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SCINScinderin. (718 aa)
RRASRAS related. (203 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1062 aa)
PAK6Non-specific serine/threonine protein kinase. (670 aa)
Nckap1lUncharacterized protein. (633 aa)
LOC100566319Uncharacterized protein. (254 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (490 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
LOC100555639Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
actg1Actin gamma 1. (374 aa)
MYL10Myosin light chain 10. (167 aa)
INSRRTyrosine-protein kinase receptor. (1377 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1075 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2021 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FN1Fibronectin 1. (2444 aa)
pik3r3Uncharacterized protein. (473 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1083 aa)
LOC100560478Uncharacterized protein. (553 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (585 aa)
PDGFCPlatelet derived growth factor C. (340 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (843 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
LOC100559807Uncharacterized protein. (186 aa)
EGFRReceptor protein-tyrosine kinase. (1185 aa)
APC2APC regulator of WNT signaling pathway 2. (2216 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2118 aa)
WASF2WASP family member 2. (495 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (350 aa)
tmsb4xThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (148 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1599 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (528 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (649 aa)
WASLWASP like actin nucleation promoting factor. (513 aa)
fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (247 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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