(110 nodes) Insulin signaling pathway network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MKNK2	MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (395 aa)
	map2k2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	MTOR	Serine/threonine-protein kinase TOR. (2314 aa)
	H9G414_ANOCA	Protein phosphatase 1 regulatory subunit. (283 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (797 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (741 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (850 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1282 aa)
	mknk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (466 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
	CBL	Cbl proto-oncogene. (856 aa)
	RHEB	Ras homolog, mTORC1 binding. (198 aa)
	Acaca	Uncharacterized protein. (1273 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (327 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (297 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	NRAS	NRAS proto-oncogene, GTPase. (194 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (267 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (546 aa)
	IRS1	Insulin receptor substrate 1. (1168 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit 3D. (246 aa)
	RHOQ	Ras homolog family member Q. (206 aa)
	TSC1	TSC complex subunit 1. (1234 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	G6PC3	Glucose-6-phosphatase catalytic subunit 3. (391 aa)
	GYS1	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (732 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (412 aa)
	HK2	Hexokinase 2. (917 aa)
	SHC4	SHC adaptor protein 4. (617 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1340 aa)
	CBLB	Cbl proto-oncogene B. (979 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (565 aa)
	HK3	Hexokinase 3. (689 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (187 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (320 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (528 aa)
	CRK	CRK proto-oncogene, adaptor protein. (228 aa)
	TSC2	TSC complex subunit 2. (1291 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2203 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	HKDC1	Hexokinase domain containing 1. (917 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	LOC100558982	Protein kinase domain-containing protein. (173 aa)
	Prkaca	Uncharacterized protein. (172 aa)
	FASN	Fatty acid synthase. (2510 aa)
	CALML4	Calmodulin like 4. (155 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (550 aa)
	Pik3r2	Uncharacterized protein. (215 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (258 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (657 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (807 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PHKG2	Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (402 aa)
	GCK	Phosphotransferase. (467 aa)
	PHKA2	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1243 aa)
	MAPK10	Mitogen-activated protein kinase. (442 aa)
	LOC100567364	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1072 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (314 aa)
	SOCS2	Suppressor of cytokine signaling 2. (186 aa)
	IRS4	Insulin receptor substrate 4. (976 aa)
	shc2	Uncharacterized protein. (589 aa)
	PDE3B	Phosphodiesterase. (669 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (761 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (340 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1047 aa)
	LOC100557368	acidPPc domain-containing protein. (429 aa)
	PHKB	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (809 aa)
	PYGB	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (735 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	SOCS1	Suppressor of cytokine signaling 1. (193 aa)
	LOC100566319	Uncharacterized protein. (254 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (432 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	rptor	Raptor_N domain-containing protein. (725 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1202 aa)
	pik3r3	Uncharacterized protein. (473 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (693 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	FOXO1	Forkhead box O1. (633 aa)
	SOCS3	Suppressor of cytokine signaling 3. (211 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	GYS2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (704 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (479 aa)
	LOC100559807	Uncharacterized protein. (186 aa)
	rps6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	Ppp1r3f	CBM21 domain-containing protein. (263 aa)
	LOC100560082	SH2 domain-containing protein. (169 aa)
	LOC100560886	Uncharacterized protein. (108 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (649 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (114 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (467 aa)
	LOC100552727	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (353 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (417 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	Acaca	ENSACAP00000009205	ENSACAP00000002314	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.901
ACACB	FASN	ENSACAP00000009205	ENSACAP00000009733	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.943
ACACB	PRKAA1	ENSACAP00000009205	ENSACAP00000010079	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.921
ACACB	PRKAA2	ENSACAP00000009205	ENSACAP00000006688	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.920
ACACB	PRKAB1	ENSACAP00000009205	ENSACAP00000003321	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.911
ACACB	PRKAB2	ENSACAP00000009205	ENSACAP00000012971	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.910
ACACB	PRKAG1	ENSACAP00000009205	ENSACAP00000008018	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.906
ACACB	PRKAG2	ENSACAP00000009205	ENSACAP00000002374	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.906
ACACB	PRKAG3	ENSACAP00000009205	ENSACAP00000012696	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.906
AKT1	AKT2	ENSACAP00000011395	ENSACAP00000002886	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT1	AKT3	ENSACAP00000011395	ENSACAP00000006639	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	FOXO1	ENSACAP00000011395	ENSACAP00000016353	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.973
AKT1	IKBKB	ENSACAP00000011395	ENSACAP00000012680	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.961
AKT1	IRS1	ENSACAP00000011395	ENSACAP00000003729	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.482
AKT1	LOC100567364	ENSACAP00000011395	ENSACAP00000011831	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.831
AKT1	MAPK1	ENSACAP00000011395	ENSACAP00000001346	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.922
AKT1	MAPK3	ENSACAP00000011395	ENSACAP00000014825	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.922
AKT1	MTOR	ENSACAP00000011395	ENSACAP00000000462	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR.	0.974
AKT1	PDE3B	ENSACAP00000011395	ENSACAP00000012439	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphodiesterase.	0.919
AKT1	PDPK1	ENSACAP00000011395	ENSACAP00000003468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.986