STRINGSTRING
RAB5A RAB5A PIK3C2A PIK3C2A DYNC1H1 DYNC1H1 hsp90aa1 hsp90aa1 VPS16 VPS16 ROCK2 ROCK2 map2k2 map2k2 S100A10 S100A10 EXOC5 EXOC5 ARPC2 ARPC2 vps33a vps33a ARF6 ARF6 MYL5 MYL5 MAPK1 MAPK1 RAB9A RAB9A MAP2K3 MAP2K3 nfkbia nfkbia MAPK11 MAPK11 PFN3 PFN3 MAPK12 MAPK12 pak1 pak1 rps3 rps3 MYL2 MYL2 GCC2 GCC2 tlr5 tlr5 SKP1 SKP1 FLNB FLNB DYNC1LI2 DYNC1LI2 DYNLL1 DYNLL1 NOD1 NOD1 AKT2 AKT2 irak4 irak4 NCKAP1 NCKAP1 WASF3 WASF3 PIK3CB PIK3CB VPS18 VPS18 CYFIP2 CYFIP2 Fadd Fadd STX10 STX10 KLC2 KLC2 SNX33 SNX33 RELA RELA CTNNB1 CTNNB1 DYNLT1 DYNLT1 MYO6 MYO6 PIK3CA PIK3CA SNX9 SNX9 klc4 klc4 TRAF6 TRAF6 RAB5B RAB5B DYNLL2 DYNLL2 RAB7A RAB7A ACBD3 ACBD3 PTPRC PTPRC GAPDH GAPDH KPNA1 KPNA1 MLKL MLKL AKT3 AKT3 ARHGEF26 ARHGEF26 ARF1 ARF1 TAB2 TAB2 JUN JUN TAB3 TAB3 KPNA4 KPNA4 PIK3C2B PIK3C2B PFN2 PFN2 TAB1 TAB1 LEF1 LEF1 RHOA RHOA NLRC4 NLRC4 DYNLRB2 DYNLRB2 DYNLRB1 DYNLRB1 LOC100565496 LOC100565496 flnc flnc myl9 myl9 LOC100558982 LOC100558982 ARPC4 ARPC4 MAP2K7 MAP2K7 MYD88 MYD88 NAIP NAIP CASP7 CASP7 FLNA FLNA RIPK2 RIPK2 MYC MYC tcf7l2 tcf7l2 RHOB RHOB klc1 klc1 CXCL8 CXCL8 TCF7L1 TCF7L1 MAPK8 MAPK8 AKT1 AKT1 RHOH RHOH MAPK10 MAPK10 LOC100567364 LOC100567364 CHUK CHUK LOC100553105 LOC100553105 DYNC2H1 DYNC2H1 CDC42 CDC42 birc2 birc2 RAB7B RAB7B LOC103278612 LOC103278612 IKBKB IKBKB RAC1 RAC1 cd14 cd14 TXN TXN PLEKHM1 PLEKHM1 Ly96 Ly96 CYTH3 CYTH3 LOC100560655 LOC100560655 PAK3 PAK3 PIK3CD PIK3CD LOC100554079 LOC100554079 TLR4 TLR4 KPNA3 KPNA3 RHOG RHOG PIK3C3 PIK3C3 RAB9B RAB9B DYNC1I1 DYNC1I1 Nckap1l Nckap1l DYNC1LI1 DYNC1LI1 DYNLT3 DYNLT3 HSP90AB1 HSP90AB1 PIK3CG PIK3CG HRAS HRAS LOC100562114 LOC100562114 MAPK3 MAPK3 LOC100555639 LOC100555639 DYNC2LI1 DYNC2LI1 actg1 actg1 MYL10 MYL10 VPS39 VPS39 H9GM92_ANOCA H9GM92_ANOCA SNX18 SNX18 DNM2 DNM2 ANXA2 ANXA2 CSE1L CSE1L ARPC3 ARPC3 RHOJ RHOJ HSP90B1 HSP90B1 CYTH1 CYTH1 TXN2 TXN2 TNFSF10 TNFSF10 BAK1 BAK1 DYNC1I2 DYNC1I2 MAPK9 MAPK9 cyth2 cyth2 PKN1 PKN1 MAPK13 MAPK13 MAPK14 MAPK14 H9GNX9_ANOCA H9GNX9_ANOCA Exoc4 Exoc4 LOC100566904 LOC100566904 MAP2K4 MAP2K4 M6PR M6PR BAX BAX RALA RALA VPS41 VPS41 RIPK1 RIPK1 ELMO1 ELMO1 EXOC2 EXOC2 rab5c rab5c tlr2 tlr2 LOC100561101 LOC100561101 vps11 vps11 LOC100555944 LOC100555944 LOC103279342 LOC103279342 TRADD TRADD TIRAP TIRAP LOC100564690 LOC100564690 MAP3K7 MAP3K7 Rilp Rilp RAF1 RAF1 LOC100559769 LOC100559769 LOC100559887 LOC100559887 rufy4 rufy4 LOC103278072 LOC103278072 WASL WASL IL6 IL6 TXNDC8 TXNDC8 map2k6 map2k6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB5ARAB5A, member RAS oncogene family. (215 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1691 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4657 aa)
hsp90aa1HATPase_c domain-containing protein. (728 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (836 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
map2k2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
EXOC5Exocyst complex component 5. (742 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (396 aa)
vps33aUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
MYL5Myosin light chain 5. (172 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (348 aa)
nfkbiaANK_REP_REGION domain-containing protein. (310 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
pak1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
MYL2Myosin light chain 2. (165 aa)
GCC2GRIP and coiled-coil domain containing 2. (1681 aa)
tlr5TIR domain-containing protein; Belongs to the Toll-like receptor family. (883 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
FLNBFilamin B. (2545 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (538 aa)
DYNLL1Dynein light chain. (89 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (950 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
irak4Interleukin 1 receptor associated kinase 4. (498 aa)
NCKAP1NCK associated protein 1. (1128 aa)
WASF3WASP family member 3. (491 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (974 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
FaddDeath domain-containing protein. (110 aa)
STX10Syntaxin 10. (243 aa)
KLC2Kinesin light chain 2. (626 aa)
SNX33Sorting nexin. (565 aa)
RELARELA proto-oncogene, NF-kB subunit. (243 aa)
CTNNB1Catenin beta 1. (781 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1263 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SNX9Sorting nexin. (608 aa)
klc4TPR_REGION domain-containing protein. (636 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (548 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
DYNLL2Dynein light chain. (89 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
ACBD3Acyl-CoA binding domain containing 3. (527 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1269 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
KPNA1Karyopherin subunit alpha 1. (652 aa)
MLKLMixed lineage kinase domain like pseudokinase. (433 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (877 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (696 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (695 aa)
KPNA4Importin subunit alpha; Belongs to the importin alpha family. (504 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1631 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (535 aa)
LEF1Lymphoid enhancer binding factor 1. (403 aa)
RHOARas homolog family member A. (193 aa)
NLRC4NLR family CARD domain containing 4. (950 aa)
DYNLRB2Dynein light chain roadblock. (96 aa)
DYNLRB1Dynein light chain roadblock. (96 aa)
LOC100565496Uncharacterized protein. (172 aa)
flncUncharacterized protein. (1203 aa)
myl9Uncharacterized protein. (172 aa)
LOC100558982Protein kinase domain-containing protein. (173 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (521 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
NAIPNLR family apoptosis inhibitory protein. (1352 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (305 aa)
FLNAFilamin A. (2702 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (560 aa)
MYCTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (443 aa)
tcf7l2HMG box domain-containing protein. (475 aa)
RHOBRas homolog family member B. (197 aa)
klc1Uncharacterized protein. (744 aa)
CXCL8Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RHOHRas homolog family member H. (191 aa)
MAPK10Mitogen-activated protein kinase. (442 aa)
LOC100567364Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1072 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (679 aa)
LOC100553105Uncharacterized protein. (199 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4302 aa)
CDC42Uncharacterized protein. (80 aa)
birc2Uncharacterized protein. (603 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
LOC103278612Uncharacterized protein. (435 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (761 aa)
RAC1Rac family small GTPase 1. (192 aa)
cd14Uncharacterized protein. (456 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1067 aa)
Ly96Uncharacterized protein. (47 aa)
CYTH3Cytohesin 3. (399 aa)
LOC100560655Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
PAK3Non-specific serine/threonine protein kinase. (557 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1047 aa)
LOC100554079CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (218 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
KPNA3Importin subunit alpha; Belongs to the importin alpha family. (566 aa)
RHOGRas homolog family member G. (191 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (628 aa)
Nckap1lUncharacterized protein. (633 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (596 aa)
DYNLT3Dynein light chain Tctex-type 3. (116 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (727 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1107 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC100562114Uncharacterized protein. (191 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
LOC100555639Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
DYNC2LI1Dynein cytoplasmic 2 light intermediate chain 1. (353 aa)
actg1Actin gamma 1. (374 aa)
MYL10Myosin light chain 10. (167 aa)
VPS39VPS39 subunit of HOPS complex. (875 aa)
H9GM92_ANOCAUncharacterized protein. (170 aa)
SNX18Sorting nexin. (595 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
ANXA2Annexin. (406 aa)
CSE1LChromosome segregation 1 like. (971 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
RHOJRas homolog family member J. (212 aa)
HSP90B1Heat shock protein 90 beta family member 1. (795 aa)
CYTH1Cytohesin 1. (417 aa)
TXN2Thioredoxin 2. (171 aa)
TNFSF10TNF superfamily member 10; Belongs to the tumor necrosis factor family. (301 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (611 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
cyth2Uncharacterized protein. (415 aa)
PKN1Protein kinase N1. (943 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
H9GNX9_ANOCAELMO domain-containing protein. (216 aa)
Exoc4Sec8_exocyst domain-containing protein. (382 aa)
LOC100566904MATH domain-containing protein. (307 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (426 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (279 aa)
BAXBCL2 associated X, apoptosis regulator. (207 aa)
RALARAS like proto-oncogene A. (206 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (699 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
rab5cUncharacterized protein. (216 aa)
tlr2TIR domain-containing protein. (775 aa)
LOC100561101TNF_2 domain-containing protein. (234 aa)
vps11Uncharacterized protein. (184 aa)
LOC100555944TIR domain-containing protein; Belongs to the Toll-like receptor family. (801 aa)
LOC103279342Uncharacterized protein. (553 aa)
TRADDTNFRSF1A associated via death domain. (327 aa)
TIRAPTIR domain containing adaptor protein. (215 aa)
LOC100564690TIR domain-containing protein. (801 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (615 aa)
RilpRH2 domain-containing protein. (167 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (649 aa)
LOC100559769Uncharacterized protein. (340 aa)
LOC100559887Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
rufy4Uncharacterized protein. (1024 aa)
LOC103278072TNF_2 domain-containing protein. (239 aa)
WASLWASP like actin nucleation promoting factor. (513 aa)
IL6Interleukin 6. (211 aa)
TXNDC8Thioredoxin; Belongs to the thioredoxin family. (123 aa)
map2k6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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