(43 nodes) HDR through Single Strand Annealing (SSA), and Rad51 network (Capitella teleta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	R7T347_CAPTE	Helicase ATP-binding domain-containing protein. (1021 aa)
	R7T5F2_CAPTE	RECA_2 domain-containing protein. (274 aa)
	R7T5N4_CAPTE	REPA_OB_2 domain-containing protein. (418 aa)
	R7T6W0_CAPTE	Uncharacterized protein. (572 aa)
	R7TCT6_CAPTE	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (439 aa)
	R7TDX8_CAPTE	Cell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
	R7TJU1_CAPTE	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (934 aa)
	R7TPW7_CAPTE	Uncharacterized protein. (347 aa)
	R7TPY4_CAPTE	Uncharacterized protein. (408 aa)
	R7TQC8_CAPTE	Rad51 domain-containing protein. (139 aa)
	R7TSH5_CAPTE	FHA domain-containing protein. (318 aa)
	R7TU09_CAPTE	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1501 aa)
	R7TVE5_CAPTE	RING-type domain-containing protein. (83 aa)
	R7TZW7_CAPTE	Uncharacterized protein. (1565 aa)
	R7UB68_CAPTE	Checkpoint protein; Belongs to the HUS1 family. (278 aa)
	R7UC31_CAPTE	Uncharacterized protein. (246 aa)
	R7UDI5_CAPTE	BRCT domain-containing protein. (266 aa)
	R7UDP5_CAPTE	Uncharacterized protein. (423 aa)
	R7UEP4_CAPTE	ANK_REP_REGION domain-containing protein. (137 aa)
	R7UIT5_CAPTE	Mre11_DNA_bind domain-containing protein. (543 aa)
	R7UM34_CAPTE	HTH_40 domain-containing protein. (566 aa)
	R7UR47_CAPTE	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (818 aa)
	R7URX3_CAPTE	Uncharacterized protein. (644 aa)
	R7UTQ4_CAPTE	Uncharacterized protein. (829 aa)
	R7UZD1_CAPTE	BRCT domain-containing protein. (216 aa)
	R7V2A0_CAPTE	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (608 aa)
	R7V2E2_CAPTE	XPGI domain-containing protein. (206 aa)
	R7V2Y0_CAPTE	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (747 aa)
	R7V410_CAPTE	ANK_REP_REGION domain-containing protein. (96 aa)
	R7V578_CAPTE	Uncharacterized protein. (282 aa)
	R7V5A4_CAPTE	AAA_23 domain-containing protein. (219 aa)
	R7V9I5_CAPTE	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (599 aa)
	R7VA11_CAPTE	DUF1767 domain-containing protein. (210 aa)
	R7VA93_CAPTE	Uncharacterized protein. (112 aa)
	R7VAJ4_CAPTE	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (579 aa)
	R7VBG2_CAPTE	Uncharacterized protein. (157 aa)
	R7VC05_CAPTE	Uncharacterized protein. (1262 aa)
	R7VCA9_CAPTE	ANK_REP_REGION domain-containing protein. (88 aa)
	R7VCK8_CAPTE	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (856 aa)
	R7VEJ9_CAPTE	Uncharacterized protein. (853 aa)
	R7VIH4_CAPTE	RPA_C domain-containing protein. (217 aa)
	R7VKE9_CAPTE	Uncharacterized protein. (603 aa)
	R7VMB1_CAPTE	RECA_2 domain-containing protein. (146 aa)

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R7T347_CAPTE	R7T5F2_CAPTE	R7T347	R7T5F2	Helicase ATP-binding domain-containing protein.	RECA_2 domain-containing protein.	0.659
R7T347_CAPTE	R7T5N4_CAPTE	R7T347	R7T5N4	Helicase ATP-binding domain-containing protein.	REPA_OB_2 domain-containing protein.	0.689
R7T347_CAPTE	R7T6W0_CAPTE	R7T347	R7T6W0	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.732
R7T347_CAPTE	R7TCT6_CAPTE	R7T347	R7TCT6	Helicase ATP-binding domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.677
R7T347_CAPTE	R7TDX8_CAPTE	R7T347	R7TDX8	Helicase ATP-binding domain-containing protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.650
R7T347_CAPTE	R7TJU1_CAPTE	R7T347	R7TJU1	Helicase ATP-binding domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.677
R7T347_CAPTE	R7TPW7_CAPTE	R7T347	R7TPW7	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.775
R7T347_CAPTE	R7TPY4_CAPTE	R7T347	R7TPY4	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.830
R7T347_CAPTE	R7TQC8_CAPTE	R7T347	R7TQC8	Helicase ATP-binding domain-containing protein.	Rad51 domain-containing protein.	0.700
R7T347_CAPTE	R7TSH5_CAPTE	R7T347	R7TSH5	Helicase ATP-binding domain-containing protein.	FHA domain-containing protein.	0.924
R7T347_CAPTE	R7TU09_CAPTE	R7T347	R7TU09	Helicase ATP-binding domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.739
R7T347_CAPTE	R7TZW7_CAPTE	R7T347	R7TZW7	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.825
R7T347_CAPTE	R7UB68_CAPTE	R7T347	R7UB68	Helicase ATP-binding domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.619
R7T347_CAPTE	R7UC31_CAPTE	R7T347	R7UC31	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.830
R7T347_CAPTE	R7UDI5_CAPTE	R7T347	R7UDI5	Helicase ATP-binding domain-containing protein.	BRCT domain-containing protein.	0.922
R7T347_CAPTE	R7UDP5_CAPTE	R7T347	R7UDP5	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.854
R7T347_CAPTE	R7UEP4_CAPTE	R7T347	R7UEP4	Helicase ATP-binding domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.917
R7T347_CAPTE	R7UIT5_CAPTE	R7T347	R7UIT5	Helicase ATP-binding domain-containing protein.	Mre11_DNA_bind domain-containing protein.	0.879
R7T347_CAPTE	R7UM34_CAPTE	R7T347	R7UM34	Helicase ATP-binding domain-containing protein.	HTH_40 domain-containing protein.	0.830
R7T347_CAPTE	R7UR47_CAPTE	R7T347	R7UR47	Helicase ATP-binding domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.830

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