(158 nodes) Mixed, incl. Ubiquitin-dependent degradation of Cyclin D, and Ubiquitin-conjugating enzyme E2 network (Capitella teleta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	R7T3K8_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (389 aa)
	R7T4G7_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (177 aa)
	R7T500_CAPTE	Ubiquitin carboxyl-terminal hydrolase. (517 aa)
	R7T5W9_CAPTE	Proteasome subunit beta. (275 aa)
	R7T6H2_CAPTE	Uncharacterized protein. (828 aa)
	R7T7N5_CAPTE	USP domain-containing protein; Belongs to the peptidase C19 family. (730 aa)
	R7T7N9_CAPTE	Ubiquitin carboxyl-terminal hydrolase. (166 aa)
	R7T7P0_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
	R7TBG8_CAPTE	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (679 aa)
	R7TCI0_CAPTE	Proteasome subunit alpha type. (254 aa)
	R7TCM7_CAPTE	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (930 aa)
	R7TCQ5_CAPTE	Proteasome subunit beta. (229 aa)
	R7TCR9_CAPTE	Uncharacterized protein. (237 aa)
	R7TF07_CAPTE	Proteasome subunit alpha type. (241 aa)
	R7TFP4_CAPTE	Uncharacterized protein. (248 aa)
	R7TG79_CAPTE	PDZ domain-containing protein. (204 aa)
	R7TGD2_CAPTE	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (956 aa)
	R7TGN0_CAPTE	Uncharacterized protein. (1104 aa)
	R7TGT6_CAPTE	Uncharacterized protein. (394 aa)
	R7TGU4_CAPTE	Ubiquitin-like domain-containing protein. (115 aa)
	R7THR9_CAPTE	Proteasome subunit beta. (199 aa)
	R7TIB8_CAPTE	Proteasome subunit alpha type. (235 aa)
	R7TJ74_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (4849 aa)
	R7TJL4_CAPTE	Uncharacterized protein. (344 aa)
	R7TJR2_CAPTE	Uncharacterized protein. (457 aa)
	R7TJY7_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	R7TKT7_CAPTE	Ubiquitin carboxyl-terminal hydrolase. (798 aa)
	R7TL23_CAPTE	RPN13_C domain-containing protein. (392 aa)
	R7TL84_CAPTE	Proteasome subunit alpha type. (279 aa)
	R7TLF0_CAPTE	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (870 aa)
	R7TLX6_CAPTE	AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa)
	R7TM29_CAPTE	Ubiquitin-like domain-containing protein. (228 aa)
	R7TND3_CAPTE	MPN domain-containing protein. (411 aa)
	R7TNG5_CAPTE	TMEM189_B_dmain domain-containing protein. (285 aa)
	R7TPM6_CAPTE	Uncharacterized protein. (515 aa)
	R7TQD4_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (633 aa)
	R7TQV3_CAPTE	Ubiquitin-like domain-containing protein. (51 aa)
	R7TRE2_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	R7TS17_CAPTE	Uncharacterized protein. (538 aa)
	R7TS54_CAPTE	VWFA domain-containing protein. (417 aa)
	R7TSE7_CAPTE	Uncharacterized protein. (313 aa)
	R7TU44_CAPTE	Uncharacterized protein. (433 aa)
	R7TUT7_CAPTE	Proteasome subunit beta. (231 aa)
	R7TUX8_CAPTE	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] (412 aa)
	R7TVC4_CAPTE	Uncharacterized protein. (180 aa)
	R7TVI6_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
	R7TWD2_CAPTE	Uncharacterized protein. (107 aa)
	R7TWV5_CAPTE	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (132 aa)
	R7TWY6_CAPTE	Proteasome subunit beta; Belongs to the peptidase T1B family. (215 aa)
	R7TX70_CAPTE	PCI domain-containing protein. (423 aa)
	R7TX86_CAPTE	Uncharacterized protein. (170 aa)
	R7TXC7_CAPTE	Uncharacterized protein. (127 aa)
	R7TXH5_CAPTE	Proteasome subunit alpha type. (263 aa)
	R7TXQ8_CAPTE	BLM10_mid domain-containing protein. (1747 aa)
	R7TYJ8_CAPTE	Ubiquitin-like domain-containing protein. (93 aa)
	R7TZ08_CAPTE	PCI domain-containing protein. (448 aa)
	R7TZL0_CAPTE	OTU domain-containing protein. (265 aa)
	R7TZQ4_CAPTE	Uncharacterized protein. (924 aa)
	R7U3X7_CAPTE	Uncharacterized protein. (1075 aa)
	R7U3Z5_CAPTE	UBA_e1_C domain-containing protein. (1007 aa)
	R7U442_CAPTE	Uncharacterized protein. (202 aa)
	R7U506_CAPTE	Uncharacterized protein. (393 aa)
	R7U554_CAPTE	Ubiquitin-like domain-containing protein. (51 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (529 aa)
	R7U692_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (303 aa)
	R7U7D4_CAPTE	USP domain-containing protein; Belongs to the peptidase C19 family. (1244 aa)
	R7U7M1_CAPTE	AAA domain-containing protein; Belongs to the AAA ATPase family. (265 aa)
	R7UA52_CAPTE	PAW domain-containing protein. (636 aa)
	R7UB63_CAPTE	Uncharacterized protein. (147 aa)
	R7UBE7_CAPTE	Proteasome subunit alpha type. (246 aa)
	R7UCJ2_CAPTE	Uncharacterized protein. (472 aa)
	R7UCP3_CAPTE	HECT domain-containing protein. (651 aa)
	R7UEM3_CAPTE	MPN domain-containing protein. (438 aa)
	R7UF00_CAPTE	Uncharacterized protein. (227 aa)
	R7UF29_CAPTE	Uncharacterized protein. (116 aa)
	R7UF81_CAPTE	Ubiquitin-like domain-containing protein. (70 aa)
	R7UFI7_CAPTE	Ubiquitin carboxyl-terminal hydrolase. (466 aa)
	R7UFI8_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
	R7UFM4_CAPTE	Ubiquitin-like domain-containing protein. (59 aa)
	R7UGF4_CAPTE	Proteasome subunit beta. (273 aa)
	R7UI95_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (113 aa)
	R7UJU2_CAPTE	Uncharacterized protein. (167 aa)
	R7ULA6_CAPTE	Uncharacterized protein. (320 aa)
	R7ULJ9_CAPTE	Uncharacterized protein. (218 aa)
	R7ULP6_CAPTE	MPN domain-containing protein. (312 aa)
	R7ULT5_CAPTE	AAA domain-containing protein; Belongs to the AAA ATPase family. (393 aa)
	R7UM57_CAPTE	ThiF domain-containing protein. (415 aa)
	R7UMB4_CAPTE	Uncharacterized protein. (496 aa)
	R7UMB7_CAPTE	Proteasome endopeptidase complex. (166 aa)
	R7UML3_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	R7UMZ7_CAPTE	Uncharacterized protein. (503 aa)
	R7UN64_CAPTE	PCI domain-containing protein. (265 aa)
	R7UNK8_CAPTE	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	R7UPF5_CAPTE	Uncharacterized protein. (1857 aa)
	R7UQ75_CAPTE	Proteasome subunit beta. (272 aa)
	R7UQG4_CAPTE	Proteasome subunit beta. (205 aa)
	R7URK7_CAPTE	AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
	R7US71_CAPTE	Uncharacterized protein. (231 aa)
	R7USI7_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
	R7UTL8_CAPTE	USP domain-containing protein; Belongs to the peptidase C19 family. (1084 aa)
	R7UU90_CAPTE	Uncharacterized protein. (339 aa)
	R7UUW9_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (239 aa)
	R7UV76_CAPTE	Uncharacterized protein. (532 aa)
	R7UV82_CAPTE	ANK_REP_REGION domain-containing protein. (171 aa)
	R7UVA7_CAPTE	MIB/HERC2 domain-containing protein. (75 aa)
	R7UVD2_CAPTE	Uncharacterized protein. (59 aa)
	R7UVV5_CAPTE	UBA domain-containing protein. (335 aa)
	R7UW77_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
	R7UWG9_CAPTE	RBR-type E3 ubiquitin transferase. (503 aa)
	R7UWH8_CAPTE	Uncharacterized protein. (356 aa)
	R7UX04_CAPTE	Uncharacterized protein. (375 aa)
	R7UXM0_CAPTE	Uncharacterized protein. (591 aa)
	R7UY95_CAPTE	Ubiquitin-like domain-containing protein. (50 aa)
	R7UYN8_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (137 aa)
	R7UZQ8_CAPTE	RBR-type E3 ubiquitin transferase. (757 aa)
	R7V023_CAPTE	Uncharacterized protein. (280 aa)
	R7V070_CAPTE	RING-type domain-containing protein. (263 aa)
	R7V1B5_CAPTE	Ubiquitin-like domain-containing protein. (179 aa)
	R7V245_CAPTE	IBR domain-containing protein. (269 aa)
	R7V2C0_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (235 aa)
	R7V2S5_CAPTE	AN1-type domain-containing protein. (89 aa)
	R7V359_CAPTE	Ubiquitin carboxyl-terminal hydrolase. (344 aa)
	R7V396_CAPTE	RBR-type E3 ubiquitin transferase. (414 aa)
	R7V3P3_CAPTE	RPN6_N domain-containing protein. (290 aa)
	R7V3W5_CAPTE	Uncharacterized protein. (597 aa)
	R7V436_CAPTE	ANK_REP_REGION domain-containing protein. (117 aa)
	R7V5I4_CAPTE	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1061 aa)
	R7V6B0_CAPTE	Uncharacterized protein. (555 aa)
	R7V700_CAPTE	Ubiquitin-like domain-containing protein. (99 aa)
	R7V7S0_CAPTE	AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
	R7V7V9_CAPTE	AAA domain-containing protein. (966 aa)
	R7V8I0_CAPTE	RBR-type E3 ubiquitin transferase. (488 aa)
	R7V9J6_CAPTE	Proteasome subunit alpha type. (252 aa)
	R7VA27_CAPTE	PCI domain-containing protein. (515 aa)
	R7VAC1_CAPTE	Uncharacterized protein. (106 aa)
	R7VAJ1_CAPTE	Uncharacterized protein. (188 aa)
	R7VAQ4_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	R7VAV4_CAPTE	PCI domain-containing protein. (389 aa)
	R7VBF4_CAPTE	Proteasome endopeptidase complex. (241 aa)
	R7VBY0_CAPTE	AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
	R7VCK5_CAPTE	Uncharacterized protein. (710 aa)
	R7VCT5_CAPTE	Uncharacterized protein. (325 aa)
	R7VD94_CAPTE	FGGY_N domain-containing protein. (292 aa)
	R7VDF8_CAPTE	RBR-type E3 ubiquitin transferase. (1101 aa)
	R7VDP4_CAPTE	Uncharacterized protein. (131 aa)
	R7VE13_CAPTE	U-box domain-containing protein. (996 aa)
	R7VE49_CAPTE	Uncharacterized protein. (166 aa)
	R7VEA5_CAPTE	RBR-type E3 ubiquitin transferase. (310 aa)
	R7VEB6_CAPTE	UBIQUITIN_CONJUGAT_2 domain-containing protein. (1158 aa)
	R7VEY1_CAPTE	RBR-type E3 ubiquitin transferase. (336 aa)
	R7VF96_CAPTE	Uncharacterized protein. (382 aa)
	R7VFM5_CAPTE	Uncharacterized protein. (265 aa)
	R7VG07_CAPTE	Uncharacterized protein. (1640 aa)
	R7VH85_CAPTE	Ubiquitin-like domain-containing protein. (93 aa)
	R7VI40_CAPTE	Uncharacterized protein. (126 aa)
	R7VIJ8_CAPTE	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
	R7VKA5_CAPTE	Uncharacterized protein. (1030 aa)
	R7VKY2_CAPTE	Ubiquitin-like domain-containing protein. (79 aa)

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KATNAL2	R7T4G7_CAPTE	R7U5C0	R7T4G7	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.703
KATNAL2	R7T500_CAPTE	R7U5C0	R7T500	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Ubiquitin carboxyl-terminal hydrolase.	0.891
KATNAL2	R7T5W9_CAPTE	R7U5C0	R7T5W9	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Proteasome subunit beta.	0.925
KATNAL2	R7T7N5_CAPTE	R7U5C0	R7T7N5	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.664
KATNAL2	R7T7N9_CAPTE	R7U5C0	R7T7N9	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Ubiquitin carboxyl-terminal hydrolase.	0.773
KATNAL2	R7TCI0_CAPTE	R7U5C0	R7TCI0	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Proteasome subunit alpha type.	0.925
KATNAL2	R7TCQ5_CAPTE	R7U5C0	R7TCQ5	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Proteasome subunit beta.	0.925
KATNAL2	R7TCR9_CAPTE	R7U5C0	R7TCR9	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Uncharacterized protein.	0.863
KATNAL2	R7TF07_CAPTE	R7U5C0	R7TF07	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Proteasome subunit alpha type.	0.925
KATNAL2	R7TFP4_CAPTE	R7U5C0	R7TFP4	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Uncharacterized protein.	0.924
KATNAL2	R7TG79_CAPTE	R7U5C0	R7TG79	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	PDZ domain-containing protein.	0.897
KATNAL2	R7TGD2_CAPTE	R7U5C0	R7TGD2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.999
KATNAL2	R7TGN0_CAPTE	R7U5C0	R7TGN0	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Uncharacterized protein.	0.448
KATNAL2	R7TGU4_CAPTE	R7U5C0	R7TGU4	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Ubiquitin-like domain-containing protein.	0.906
KATNAL2	R7THR9_CAPTE	R7U5C0	R7THR9	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Proteasome subunit beta.	0.925
KATNAL2	R7TIB8_CAPTE	R7U5C0	R7TIB8	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Proteasome subunit alpha type.	0.974
KATNAL2	R7TJ74_CAPTE	R7U5C0	R7TJ74	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.784
KATNAL2	R7TJR2_CAPTE	R7U5C0	R7TJR2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Uncharacterized protein.	0.904
KATNAL2	R7TJY7_CAPTE	R7U5C0	R7TJY7	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.703
KATNAL2	R7TL23_CAPTE	R7U5C0	R7TL23	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	RPN13_C domain-containing protein.	0.979

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