(78 nodes) DNA replication network (Capitella teleta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	R7U2I4_CAPTE	Uncharacterized protein. (170 aa)
	R7VKU2_CAPTE	AAA domain-containing protein. (340 aa)
	R7VKE9_CAPTE	Uncharacterized protein. (603 aa)
	R7VJK2_CAPTE	Uncharacterized protein. (181 aa)
	R7VIH4_CAPTE	RPA_C domain-containing protein. (217 aa)
	R7VHF9_CAPTE	Uncharacterized protein. (301 aa)
	R7VFZ8_CAPTE	AAA domain-containing protein. (1709 aa)
	R7VF06_CAPTE	DNA polymerase. (1425 aa)
	R7VEN2_CAPTE	Uncharacterized protein. (409 aa)
	R7VEE4_CAPTE	Uncharacterized protein. (411 aa)
	R7VAU2_CAPTE	BRCT domain-containing protein. (730 aa)
	R7VA93_CAPTE	Uncharacterized protein. (112 aa)
	R7V9M8_CAPTE	Uncharacterized protein. (85 aa)
	R7V9M6_CAPTE	Uncharacterized protein. (124 aa)
	R7V768_CAPTE	Poly [ADP-ribose] polymerase. (153 aa)
	R7V762_CAPTE	Uncharacterized protein. (494 aa)
	R7V6X5_CAPTE	DNA helicase; Belongs to the MCM family. (836 aa)
	R7V615_CAPTE	VWFA domain-containing protein. (302 aa)
	R7V3G1_CAPTE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2273 aa)
	R7V2U4_CAPTE	DNA helicase; Belongs to the MCM family. (732 aa)
	R7V2E2_CAPTE	XPGI domain-containing protein. (206 aa)
	R7V2A0_CAPTE	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (608 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (377 aa)
	R7UZN3_CAPTE	AAA domain-containing protein. (343 aa)
	R7UZD9_CAPTE	Uncharacterized protein. (1169 aa)
	R7UYG1_CAPTE	Uncharacterized protein. (571 aa)
	R7UXH4_CAPTE	Uncharacterized protein. (352 aa)
	R7UWH7_CAPTE	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
	R7UVE8_CAPTE	DNA polymerase. (573 aa)
	R7UV60_CAPTE	Uncharacterized protein. (452 aa)
	R7UQ01_CAPTE	AAA domain-containing protein. (214 aa)
	R7UNY3_CAPTE	CBFD_NFYB_HMF domain-containing protein. (112 aa)
	R7UM80_CAPTE	PH domain-containing protein. (673 aa)
	R7ULZ2_CAPTE	AAA domain-containing protein. (333 aa)
	R7UKD9_CAPTE	Uncharacterized protein. (103 aa)
	R7UJZ4_CAPTE	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (513 aa)
	R7UHG3_CAPTE	MCM_lid domain-containing protein. (190 aa)
	R7UGC3_CAPTE	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
	R7UE34_CAPTE	Uncharacterized protein. (465 aa)
	R7UE23_CAPTE	Macro domain-containing protein. (191 aa)
	R7UDQ3_CAPTE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (706 aa)
	R7UDL4_CAPTE	RNase H domain-containing protein. (146 aa)
	R7UCQ9_CAPTE	Uncharacterized protein. (140 aa)
	R7UBP8_CAPTE	Torsin. (348 aa)
	R7UBH1_CAPTE	Replicative DNA helicase. (397 aa)
	R7UB80_CAPTE	Uncharacterized protein. (130 aa)
	R7U9D6_CAPTE	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	R7U8U8_CAPTE	RRM domain-containing protein. (1004 aa)
	R7U7W9_CAPTE	DNA ligase. (603 aa)
	R7U7R0_CAPTE	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (317 aa)
	R7U5X9_CAPTE	AAA domain-containing protein. (358 aa)
	R7U4I9_CAPTE	Uncharacterized protein. (328 aa)
	R7U3M0_CAPTE	RNase H domain-containing protein. (142 aa)
	R7U2B0_CAPTE	Uncharacterized protein. (97 aa)
	R7U1M1_CAPTE	Macro domain-containing protein. (206 aa)
	R7U0X7_CAPTE	Uncharacterized protein. (87 aa)
	R7TW78_CAPTE	C2 domain-containing protein. (521 aa)
	R7TW05_CAPTE	Uncharacterized protein. (1812 aa)
	R7TVV9_CAPTE	CBFD_NFYB_HMF domain-containing protein. (150 aa)
	R7TV21_CAPTE	Uncharacterized protein. (409 aa)
	R7TTU7_CAPTE	Uncharacterized protein. (311 aa)
	R7TRS2_CAPTE	Uncharacterized protein. (469 aa)
	R7TQH5_CAPTE	Chromo_2 domain-containing protein. (279 aa)
	R7TPS2_CAPTE	Poly [ADP-ribose] polymerase. (1702 aa)
	R7TNS6_CAPTE	Uncharacterized protein. (200 aa)
	R7TMR8_CAPTE	MCM_lid domain-containing protein. (622 aa)
	R7TIY6_CAPTE	DNA helicase; Belongs to the MCM family. (811 aa)
	R7TIH5_CAPTE	Uncharacterized protein. (270 aa)
	R7THB3_CAPTE	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
	R7TGR0_CAPTE	Uncharacterized protein. (655 aa)
	R7TGI4_CAPTE	DNA polymerase. (1052 aa)
	R7TDJ0_CAPTE	Uncharacterized protein. (87 aa)
	R7TBK9_CAPTE	Uncharacterized protein. (537 aa)
	R7TAP1_CAPTE	DNA helicase; Belongs to the MCM family. (817 aa)
	R7TAB0_CAPTE	MCM domain-containing protein; Belongs to the MCM family. (833 aa)
	R7T7U7_CAPTE	Uncharacterized protein. (538 aa)
	R7T5N4_CAPTE	REPA_OB_2 domain-containing protein. (418 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)

Your Current Organism:

Capitella teleta

NCBI taxonomy Id: 283909
Other names: C. teleta, Capitella sp. I, Capitella sp. I AF-2005, Capitella sp. I ECS-2004, Capitella sp. I ES-2005, Capitella sp. MKJ-2016, Capitella teleta Blake, Grassle & Eckelbarger, 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	R7V1L7	R7T3M6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.869
FEN1	R7T5N4_CAPTE	R7V1L7	R7T5N4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	REPA_OB_2 domain-containing protein.	0.821
FEN1	R7T7U7_CAPTE	R7V1L7	R7T7U7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.840
FEN1	R7TAB0_CAPTE	R7V1L7	R7TAB0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	MCM domain-containing protein; Belongs to the MCM family.	0.855
FEN1	R7TAP1_CAPTE	R7V1L7	R7TAP1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.923
FEN1	R7TGI4_CAPTE	R7V1L7	R7TGI4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.994
FEN1	R7THB3_CAPTE	R7V1L7	R7THB3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.965
FEN1	R7TIH5_CAPTE	R7V1L7	R7TIH5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.721
FEN1	R7TIY6_CAPTE	R7V1L7	R7TIY6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.931
FEN1	R7TMR8_CAPTE	R7V1L7	R7TMR8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	MCM_lid domain-containing protein.	0.554
FEN1	R7TQH5_CAPTE	R7V1L7	R7TQH5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Chromo_2 domain-containing protein.	0.721
FEN1	R7TRS2_CAPTE	R7V1L7	R7TRS2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.985
FEN1	R7TVV9_CAPTE	R7V1L7	R7TVV9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CBFD_NFYB_HMF domain-containing protein.	0.838
FEN1	R7TW05_CAPTE	R7V1L7	R7TW05	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.985
FEN1	R7U0X7_CAPTE	R7V1L7	R7U0X7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.554
FEN1	R7U3M0_CAPTE	R7V1L7	R7U3M0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RNase H domain-containing protein.	0.738
FEN1	R7U5X9_CAPTE	R7V1L7	R7U5X9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.972
FEN1	R7U7R0_CAPTE	R7V1L7	R7U7R0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.778
FEN1	R7U7W9_CAPTE	R7V1L7	R7U7W9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.994
FEN1	R7U9D6_CAPTE	R7V1L7	R7U9D6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.999

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