STRINGSTRING
uvrB uvrB rnhB rnhB SDW08767.1 SDW08767.1 fen fen uvrC uvrC ligA ligA taw1 taw1 SDW24312.1 SDW24312.1 cca cca SDW25433.1 SDW25433.1 SDW21185.1 SDW21185.1 SDW28768.1 SDW28768.1 mutS mutS mutL mutL rfcS rfcS polC polC SDW33644.1 SDW33644.1 nfo nfo SDW43598.1 SDW43598.1 SDW43758.1 SDW43758.1 SDW45835.1 SDW45835.1 uvrA uvrA nth nth spt5 spt5 SDW55511.1 SDW55511.1 dnaG dnaG rfcL rfcL SDW66207.1 SDW66207.1 rad50 rad50 mre11 mre11 SDW67382.1 SDW67382.1 topA topA SDW76729.1 SDW76729.1 priS priS SDW79807.1 SDW79807.1 spt4 spt4 priL priL pcn pcn SDW79839.1 SDW79839.1 polB polB SDW81018.1 SDW81018.1 lig lig dbh dbh SDX00055.1 SDX00055.1 radB radB SDX06076.1 SDX06076.1 SDX07527.1 SDX07527.1 SDX14082.1 SDX14082.1 SDX16358.1 SDX16358.1 taw2 taw2 radA radA mutS-2 mutS-2 endA endA SDX20341.1 SDX20341.1 SDX21549.1 SDX21549.1 SDX21435.1 SDX21435.1 SDX22705.1 SDX22705.1 SDX23976.1 SDX23976.1 SDX24003.1 SDX24003.1 SDX24168.1 SDX24168.1 SDX26418.1 SDX26418.1 SDX30770.1 SDX30770.1 SDX32809.1 SDX32809.1 SDX34223.1 SDX34223.1 SDX34283.1 SDX34283.1 SDX34876.1 SDX34876.1 SDX36151.1 SDX36151.1 SDX37661.1 SDX37661.1 SDX37682.1 SDX37682.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (686 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (211 aa)
SDW08767.1Hypothetical protein; Involved in DNA damage repair. (429 aa)
fenFlap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (326 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (581 aa)
ligADNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (693 aa)
taw1tRNA wybutosine-synthesizing protein 1; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (326 aa)
SDW24312.1ATP-dependent DNA helicase, Rep family. (613 aa)
ccatRNA adenylyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (466 aa)
SDW25433.1Replication factor A1. (490 aa)
SDW21185.1DNA helicase-4. (1120 aa)
SDW28768.1Replication factor C small subunit. (366 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (921 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (717 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (325 aa)
polCDNA polymerase II large subunit /intein; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1395 aa)
SDW33644.1Fanconi anemia group M protein. (837 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (277 aa)
SDW43598.1methylated-DNA-[protein]-cysteine S-methyltransferase. (156 aa)
SDW43758.1Endonuclease-3. (277 aa)
SDW45835.1Replication factor A1. (94 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (993 aa)
nthDNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
spt5LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (145 aa)
SDW55511.1DNA polymerase (family 10). (578 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (445 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (503 aa)
SDW66207.1Replicative DNA polymerase I. (935 aa)
rad50Exonuclease SbcC; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily. (891 aa)
mre11DNA repair exonuclease SbcCD nuclease subunit; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. (417 aa)
SDW67382.1GTP-binding conserved hypothetical protein TIGR00650. (395 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (827 aa)
SDW76729.1GTP-binding conserved hypothetical protein TIGR00650. (393 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (392 aa)
SDW79807.1Hypothetical protein. (45 aa)
spt4DNA-directed RNA polymerase, subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (65 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (358 aa)
pcnMonomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
SDW79839.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (524 aa)
polBDNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (522 aa)
SDW81018.1Replicative DNA helicase Mcm; Belongs to the MCM family. (698 aa)
ligDNA ligase-1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (553 aa)
dbhDNA polymerase IV (DinB-like DNA polymerase); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (449 aa)
SDX00055.1Hypothetical protein. (719 aa)
radBDNA repair protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (236 aa)
SDX06076.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (414 aa)
SDX07527.1Endonuclease-3. (233 aa)
SDX14082.1Cell division control protein 6; Involved in regulation of DNA replication. (395 aa)
SDX16358.1Ribonuclease HI. (224 aa)
taw2Methyltransferase; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (363 aa)
radADNA repair protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (349 aa)
mutS-2DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (945 aa)
endAtRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (341 aa)
SDX20341.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (442 aa)
SDX21549.1ORC complex protein Cdc6/Orc1. (342 aa)
SDX21435.1DNA polymerase I. (720 aa)
SDX22705.1Hypothetical protein. (122 aa)
SDX23976.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (484 aa)
SDX24003.1DNA polymerase I. (716 aa)
SDX24168.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (342 aa)
SDX26418.1Hypothetical protein. (286 aa)
SDX30770.1DNA-3-methyladenine glycosylase II. (203 aa)
SDX32809.1Cell division control protein 6; Involved in regulation of DNA replication. (252 aa)
SDX34223.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (418 aa)
SDX34283.1Proliferating cell antigen. (290 aa)
SDX34876.1ERCC4 domain-containing protein. (165 aa)
SDX36151.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (454 aa)
SDX37661.1Hypothetical protein. (383 aa)
SDX37682.1Hypothetical protein. (319 aa)
Your Current Organism:
Haloarcula vallismortis
NCBI taxonomy Id: 28442
Other names: ATCC 29715, CGMCC 1.2048, DSM 3756, H. vallismortis, Halobacterium vallismortis, IFO 14741, JCM 8877, NBRC 14741, strain J. F. 54
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.