STRINGSTRING
purQ purQ purS purS SDW07623.1 SDW07623.1 adk adk carB carB carA carA map map guaAB guaAB SDW14309.1 SDW14309.1 SDW28885.1 SDW28885.1 pyrE pyrE purO purO pyrC pyrC SDW43878.1 SDW43878.1 purF purF guaB guaB guaAA guaAA SDW74593.1 SDW74593.1 SDW74682.1 SDW74682.1 SDW77754.1 SDW77754.1 SDW86794.1 SDW86794.1 SDW86841.1 SDW86841.1 purD purD pyrB pyrB pyrI pyrI SDW93427.1 SDW93427.1 SDW94867.1 SDW94867.1 surE surE purK purK pyrF pyrF purE purE SDX06738.1 SDX06738.1 purL purL SDX18111.1 SDX18111.1 pyrD pyrD purA purA purM purM SDX36533.1 SDX36533.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (228 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (84 aa)
SDW07623.1Phosphoribosylaminoimidazole-succinocarboxamide synthase. (344 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1083 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (348 aa)
mapMethionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (298 aa)
guaABGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (305 aa)
SDW14309.1Adenine phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown. (189 aa)
SDW28885.1dITPase. (223 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (183 aa)
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (202 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (443 aa)
SDW43878.1Adenine phosphoribosyltransferase. (182 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (480 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
guaAAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (189 aa)
SDW74593.1IMP cyclohydrolase. (526 aa)
SDW74682.1Adenylosuccinate lyase. (460 aa)
SDW77754.1Phosphoribosylamine--glycine ligase. (166 aa)
SDW86794.1Dihydropyrimidinase/dihydroorotase. (447 aa)
SDW86841.1Nucleobase:cation symporter-2, NCS2 family. (468 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (449 aa)
pyrBAspartate carbamoyltransferase. (304 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (155 aa)
SDW93427.1Phosphoribosylamine--glycine ligase. (33 aa)
SDW94867.1Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (168 aa)
surE5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (269 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (381 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (277 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (216 aa)
SDX06738.1Inosine-5'-monophosphate dehydrogenase. (369 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (721 aa)
SDX18111.1GMP synthase (glutamine-hydrolysing). (238 aa)
pyrDDihydroorotate oxidase A /dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (350 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (458 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (338 aa)
SDX36533.1GMP synthase (glutamine-hydrolysing). (112 aa)
Your Current Organism:
Haloarcula vallismortis
NCBI taxonomy Id: 28442
Other names: ATCC 29715, CGMCC 1.2048, DSM 3756, H. vallismortis, Halobacterium vallismortis, IFO 14741, JCM 8877, NBRC 14741, strain J. F. 54
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.