(98 nodes) Formation of a pool of free 40S subunits network (Kluyveromyces lactis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KLLA0_E00573g	KLLA0E00573p. (255 aa)
	KLLA0_E22001g	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (199 aa)
	KLLA0_B11231g	KLLA0B11231p; Belongs to the universal ribosomal protein uS12 family. (145 aa)
	KLLA0_F06831g	KLLA0F06831p; Belongs to the universal ribosomal protein uL15 family. (149 aa)
	RPS14	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (137 aa)
	RPL44	60S ribosomal protein L44. (106 aa)
	RPS28	40S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (67 aa)
	RPL30	60S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family. (105 aa)
	RPL24	60S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. (155 aa)
	KLLA0_F26092g	KLLA0F26092p. (471 aa)
	KLLA0_F25542g	KLLA0F25542p. (117 aa)
	KLLA0_F23265g	KLLA0F23265p. (967 aa)
	KLLA0_F18040g	KLLA0F18040p; Belongs to the universal ribosomal protein uS15 family. (151 aa)
	KLLA0_F17633g	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
	RPL3	60S ribosomal protein L3. (387 aa)
	KLLA0_F16214g	KLLA0F16214p. (118 aa)
	KLLA0_F15180g	KLLA0F15180p. (524 aa)
	COX16	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family. (118 aa)
	KLLA0_F12210g	KLLA0F12210p. (1044 aa)
	KLLA0_F09812g	KLLA0F09812p; Belongs to the universal ribosomal protein uS5 family. (259 aa)
	KLLA0_F08657g	60S ribosomal protein L20; Belongs to the eukaryotic ribosomal protein eL20 family. (146 aa)
	KLLA0_F08261g	KLLA0F08261p; Belongs to the universal ribosomal protein uL5 family. (174 aa)
	KLLA0_F07865g	KLLA0F07865p; Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa)
	KLLA0_F07843g	KLLA0F07843p; Belongs to the universal ribosomal protein uS19 family. (142 aa)
	KLLA0_F05555g	KLLA0F05555p; Belongs to the eukaryotic ribosomal protein P1/P2 family. (104 aa)
	KLLA0_F05247g	KLLA0F05247p. (120 aa)
	KLLA0_F04675g	KLLA0F04675p; Belongs to the universal ribosomal protein uL13 family. (199 aa)
	KLLA0_F04499g	KLLA0F04499p. (191 aa)
	KLLA0_F00352g	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (134 aa)
	RPS6	40S ribosomal protein S6. (236 aa)
	KLLA0_E23673g	KLLA0E23673p; Belongs to the universal ribosomal protein uS4 family. (188 aa)
	KLLA0_E23651g	KLLA0E23651p. (160 aa)
	KLLA0_E22199g	Eukaryotic translation initiation factor 5A. (157 aa)
	KLLA0_E22023g	KLLA0E22023p; Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa)
	KLLA0_E20461g	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (201 aa)
	RPS0	40S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (254 aa)
	KLLA0_E12453g	KLLA0E12453p. (189 aa)
	KLLA0_E12277g	KLLA0E12277p. (326 aa)
	KLLA0_E11661g	40S ribosomal protein S27. (82 aa)
	KLLA0_E11287g	KLLA0E11287p; Belongs to the eIF-1A family. (155 aa)
	KLLA0_E09109g	KLLA0E09109p. (191 aa)
	KLLA0_E06997g	KLLA0E06997p; Belongs to the universal ribosomal protein uL14 family. (137 aa)
	KLLA0_E06843g	KLLA0E06843p. (130 aa)
	KLLA0_E05941g	KLLA0E05941p. (92 aa)
	RPS29	40S ribosomal protein S29; Belongs to the universal ribosomal protein uS14 family. (56 aa)
	KLLA0_E03455g	KLLA0E03455p. (136 aa)
	EFT1	Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (842 aa)
	KLLA0_E02861g	KLLA0E02861p; Belongs to the eukaryotic ribosomal protein P1/P2 family. (109 aa)
	KLLA0_E01453g	KLLA0E01453p. (155 aa)
	KLLA0_D16071g	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family. (62 aa)
	KLLA0_D16027g	KLLA0D16027p. (254 aa)
	KLLA0_D12540g	60S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (100 aa)
	KLLA0_D11594g	KLLA0D11594p; Belongs to the GST superfamily. (219 aa)
	KLLA0_D10659g	KLLA0D10659p; Belongs to the universal ribosomal protein uS7 family. (227 aa)
	KLLA0_D08305g	KLLA0D08305p; Belongs to the universal ribosomal protein uS3 family. (237 aa)
	KLLA0_D07405g	KLLA0D07405p. (107 aa)
	KLLA0_D05643g	KLLA0D05643p. (220 aa)
	KLLA0_D05181g	KLLA0D05181p. (122 aa)
	KLLA0_D05115g	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (119 aa)
	KLLA0_D03410g	KLLA0D03410p. (241 aa)
	KLLA0_C18469g	KLLA0C18469p; Belongs to the EF-1-beta/EF-1-delta family. (207 aa)
	KLLA0_C18216g	KLLA0C18216p; Belongs to the eukaryotic ribosomal protein eL38 family. (78 aa)
	KLLA0_C17050g	KLLA0C17050p. (955 aa)
	KLLA0_C16115g	KLLA0C16115p. (1183 aa)
	KLLA0_C13519g	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (190 aa)
	TCTP_KLULA	Translationally-controlled tumor protein homolog; Involved in protein synthesis. Involved in microtubule stabilization (By similarity); Belongs to the TCTP family. (167 aa)
	KLLA0_C11297g	KLLA0C11297p; Belongs to the universal ribosomal protein uS13 family. (137 aa)
	KLLA0_C08371g	KLLA0C08371p. (125 aa)
	KLLA0_C07755g	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (135 aa)
	KLLA0_C04809g	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (63 aa)
	KLLA0_C01870g	Ribosomal protein L37; Binds to the 23S rRNA. (88 aa)
	KLLA0_B13409g	KLLA0B13409p. (138 aa)
	KLLA0_B08998g	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (458 aa)
	KLLA0_B08173g	KLLA0B08173p. (106 aa)
	KLLA0_B07931g	KLLA0B07931p; Belongs to the universal ribosomal protein uS8 family. (130 aa)
	RPS22	40S ribosomal protein S22; Belongs to the universal ribosomal protein uS8 family. (130 aa)
	RPL39	60S ribosomal protein L39. (51 aa)
	KLLA0_B07139g	KLLA0B07139p. (363 aa)
	KLLA0_B06182g	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (108 aa)
	KLLA0_B05918g	60S acidic ribosomal protein P0; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome t [...] (311 aa)
	KLLA0_B05742g	KLLA0B05742p. (127 aa)
	RPS1	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family. (255 aa)
	KLLA0_B04686g	KLLA0B04686p. (175 aa)
	KLLA0_B03652g	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (261 aa)
	KLLA0_B02937g	KLLA0B02937p. (114 aa)
	KLLA0_B02002g	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family. (217 aa)
	KLLA0_B01562g	KLLA0B01562p; Belongs to the universal ribosomal protein uS13 family. (146 aa)
	KLLA0_B01474g	KLLA0B01474p. (136 aa)
	KLLA0_A11660g	KLLA0A11660p. (482 aa)
	KLLA0_A10483g	KLLA0A10483p; Belongs to the universal ribosomal protein uS17 family. (156 aa)
	KLLA0_A08107g	KLLA0A08107p. (385 aa)
	KLLA0_A07227g	KLLA0A07227p. (186 aa)
	KLLA0_A07194g	KLLA0A07194p. (144 aa)
	KLLA0_A06798g	KLLA0A06798p; Belongs to the universal ribosomal protein uL14 family. (138 aa)
	KLLA0_A06336g	KLLA0A06336p; Belongs to the universal ribosomal protein uL22 family. (184 aa)
	RPS21	40S ribosomal protein S21; Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (By similarity). (87 aa)
	KLLA0_A01903g	KLLA0A01903p; Belongs to the universal ribosomal protein uL11 family. (165 aa)
	RPS16	40S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (143 aa)

Your Current Organism:

Kluyveromyces lactis

NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX16	EFT1	Q6CK73	Q6CPQ9	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]	0.769
COX16	KLLA0_A01903g	Q6CK73	Q6CYA5	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A01903p; Belongs to the universal ribosomal protein uL11 family.	0.753
COX16	KLLA0_A06336g	Q6CK73	Q6CXQ6	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A06336p; Belongs to the universal ribosomal protein uL22 family.	0.938
COX16	KLLA0_A06798g	Q6CK73	Q6CXN6	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A06798p; Belongs to the universal ribosomal protein uL14 family.	0.783
COX16	KLLA0_A07194g	Q6CK73	Q6CXM0	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A07194p.	0.913
COX16	KLLA0_A07227g	Q6CK73	Q6CXL8	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A07227p.	0.919
COX16	KLLA0_A08107g	Q6CK73	Q6CXH9	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A08107p.	0.826
COX16	KLLA0_A10483g	Q6CK73	Q6CX80	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A10483p; Belongs to the universal ribosomal protein uS17 family.	0.906
COX16	KLLA0_A11660g	Q6CK73	Q6CX32	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0A11660p.	0.762
COX16	KLLA0_B01474g	Q6CK73	Q6CWU3	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B01474p.	0.915
COX16	KLLA0_B01562g	Q6CK73	Q6CWT9	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B01562p; Belongs to the universal ribosomal protein uS13 family.	0.914
COX16	KLLA0_B02002g	Q6CK73	Q6CWR9	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.912
COX16	KLLA0_B02937g	Q6CK73	Q6CWM6	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B02937p.	0.940
COX16	KLLA0_B03652g	Q6CK73	Q6CWJ2	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family.	0.922
COX16	KLLA0_B04686g	Q6CK73	Q6CWE7	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B04686p.	0.929
COX16	KLLA0_B05742g	Q6CK73	Q6CW97	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B05742p.	0.961
COX16	KLLA0_B05918g	Q6CK73	Q6CW89	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	60S acidic ribosomal protein P0; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome t [...]	0.946
COX16	KLLA0_B06182g	Q6CK73	Q6CW78	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.906
COX16	KLLA0_B07139g	Q6CK73	Q6CW41	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B07139p.	0.886
COX16	KLLA0_B07931g	Q6CK73	Q6CW06	Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.	KLLA0B07931p; Belongs to the universal ribosomal protein uS8 family.	0.768