STRINGSTRING
SYF1 SYF1 KLLA0_C15323g KLLA0_C15323g KLLA0_C15169g KLLA0_C15169g KLLA0_C14388g KLLA0_C14388g KLLA0_C14025g KLLA0_C14025g KLLA0_C08800g KLLA0_C08800g HUB1 HUB1 KLLA0_C08019g KLLA0_C08019g CEF1 CEF1 KLLA0_C07216g KLLA0_C07216g SPP2 SPP2 KLLA0_C05192g KLLA0_C05192g KLLA0_C03322g KLLA0_C03322g CWC25 CWC25 KLLA0_B11594g KLLA0_B11594g KLLA0_B10472g KLLA0_B10472g KLLA0_B08976g KLLA0_B08976g KLLA0_B08910g KLLA0_B08910g KLLA0_B08525g KLLA0_B08525g KLLA0_B06369g KLLA0_B06369g KLLA0_B05203g KLLA0_B05203g KLLA0_B02156g KLLA0_B02156g KLLA0_B00979g KLLA0_B00979g SPT5 SPT5 KLLA0_B00627g KLLA0_B00627g KLLA0_B00561g KLLA0_B00561g KLLA0_A09537g KLLA0_A09537g RSE1 RSE1 KLLA0_A08019g KLLA0_A08019g KLLA0_A07733g KLLA0_A07733g KLLA0_A06688g KLLA0_A06688g KLLA0_A05280g KLLA0_A05280g KLLA0_A04565g KLLA0_A04565g KLLA0_A02299g KLLA0_A02299g LSM4 LSM4 KLLA0_F24662g KLLA0_F24662g KLLA0_F22473g KLLA0_F22473g CWC26 CWC26 KLLA0_F18018g KLLA0_F18018g CLF1 CLF1 KLLA0_F17523g KLLA0_F17523g ISY1 ISY1 KLLA0_F14861g KLLA0_F14861g SLU7 SLU7 KLLA0_F14344g KLLA0_F14344g PRP46 PRP46 PRP5 PRP5 KLLA0_F09207g KLLA0_F09207g KLLA0_F08591g KLLA0_F08591g KLLA0_F07249g KLLA0_F07249g KLLA0_F06204g KLLA0_F06204g KLLA0_F04191g KLLA0_F04191g PRP45 PRP45 KLLA0_E22881g KLLA0_E22881g SNU13 SNU13 SUB2 SUB2 KLLA0_E21187g KLLA0_E21187g KLLA0_E20505g KLLA0_E20505g KLLA0_E19031g KLLA0_E19031g KLLA0_E18239g KLLA0_E18239g KLLA0_E16457g KLLA0_E16457g KLLA0_E14125g KLLA0_E14125g EXO84 EXO84 KLLA0_E11045g KLLA0_E11045g KLLA0_E10209g KLLA0_E10209g KLLA0_E09285g KLLA0_E09285g KLLA0_E04929g KLLA0_E04929g KLLA0_E04819g KLLA0_E04819g LSM6 LSM6 KLLA0_E01409g KLLA0_E01409g SQS1 SQS1 KLLA0_D17160g KLLA0_D17160g CWC15 CWC15 KLLA0_D14927g KLLA0_D14927g KLLA0_D14883g KLLA0_D14883g KLLA0_D13420g KLLA0_D13420g KLLA0_D09526g KLLA0_D09526g KLLA0_D09284g KLLA0_D09284g KLLA0_D07678g KLLA0_D07678g KLLA0_D04466g KLLA0_D04466g KLLA0_D03883g KLLA0_D03883g KLLA0_D03795g KLLA0_D03795g KLLA0_D02728g KLLA0_D02728g CWC24 CWC24 SNU71 SNU71 KLLA0_C17798g KLLA0_C17798g KLLA0_C15675g KLLA0_C15675g PRP28 PRP28 CWC2 CWC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYF1Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing and cell cycle progression. (798 aa)
KLLA0_C15323gKLLA0C15323p. (462 aa)
KLLA0_C15169gKLLA0C15169p. (549 aa)
KLLA0_C14388gKLLA0C14388p. (203 aa)
KLLA0_C14025gKLLA0C14025p. (529 aa)
KLLA0_C08800gKLLA0C08800p. (157 aa)
HUB1Ubiquitin-like modifier HUB1. (74 aa)
KLLA0_C08019gKLLA0C08019p. (301 aa)
CEF1Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control. (543 aa)
KLLA0_C07216gKLLA0C07216p. (683 aa)
SPP2Pre-mRNA-splicing factor SPP2; Involved in spliceosome maturation and the first step of pre- mRNA splicing. (189 aa)
KLLA0_C05192gKLLA0C05192p. (189 aa)
KLLA0_C03322gKLLA0C03322p. (385 aa)
CWC25Pre-mRNA-splicing factor CWC25; Involved in pre-mRNA splicing. (206 aa)
KLLA0_B11594gKLLA0B11594p. (114 aa)
KLLA0_B10472gNuclear cap-binding protein subunit 2. (198 aa)
KLLA0_B08976gKLLA0B08976p. (305 aa)
KLLA0_B08910gSpliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
KLLA0_B08525gKLLA0B08525p. (326 aa)
KLLA0_B06369gKLLA0B06369p. (271 aa)
KLLA0_B05203gKLLA0B05203p. (83 aa)
KLLA0_B02156gKLLA0B02156p. (242 aa)
KLLA0_B00979gKLLA0B00979p. (342 aa)
SPT5Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (1036 aa)
KLLA0_B00627gKLLA0B00627p. (191 aa)
KLLA0_B00561gKLLA0B00561p. (767 aa)
KLLA0_A09537gKLLA0A09537p. (954 aa)
RSE1Pre-mRNA-splicing factor RSE1; Involved in pre-mRNA splicing and cell cycle control. (1269 aa)
KLLA0_A08019gKLLA0A08019p. (615 aa)
KLLA0_A07733gKLLA0A07733p. (1064 aa)
KLLA0_A06688gKLLA0A06688p. (933 aa)
KLLA0_A05280gKLLA0A05280p. (2411 aa)
KLLA0_A04565gKLLA0A04565p. (189 aa)
KLLA0_A02299gSmall nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (183 aa)
KLLA0_F24662gKLLA0F24662p. (530 aa)
KLLA0_F22473gKLLA0F22473p. (253 aa)
CWC26Pre-mRNA-splicing factor CWC26; Involved in pre-mRNA splicing. (268 aa)
KLLA0_F18018gKLLA0F18018p. (459 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)
KLLA0_F17523gKLLA0F17523p. (855 aa)
ISY1Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing. (237 aa)
KLLA0_F14861gKLLA0F14861p. (589 aa)
SLU7Pre-mRNA-splicing factor SLU7; Involved in pre-mRNA splicing. (341 aa)
KLLA0_F14344gKLLA0F14344p. (284 aa)
PRP46Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M. (434 aa)
PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (812 aa)
KLLA0_F09207gU6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
KLLA0_F08591gKLLA0F08591p. (557 aa)
KLLA0_F07249gKLLA0F07249p. (256 aa)
KLLA0_F06204gKLLA0F06204p. (877 aa)
KLLA0_F04191gKLLA0F04191p. (885 aa)
PRP45Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing. (430 aa)
KLLA0_E22881gKLLA0E22881p. (110 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (437 aa)
KLLA0_E21187gKLLA0E21187p. (429 aa)
KLLA0_E20505gKLLA0E20505p. (357 aa)
KLLA0_E19031gKLLA0E19031p. (652 aa)
KLLA0_E18239gKLLA0E18239p. (571 aa)
KLLA0_E16457gKLLA0E16457p. (96 aa)
KLLA0_E14125gKLLA0E14125p. (477 aa)
EXO84Exocyst complex component EXO84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity). (720 aa)
KLLA0_E11045gKLLA0E11045p. (432 aa)
KLLA0_E10209gKLLA0E10209p. (84 aa)
KLLA0_E09285gKLLA0E09285p. (424 aa)
KLLA0_E04929gKLLA0E04929p. (112 aa)
KLLA0_E04819gKLLA0E04819p. (459 aa)
LSM6U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (80 aa)
KLLA0_E01409gKLLA0E01409p. (186 aa)
SQS1Protein SQS1; May be involved in splicing; Belongs to the SQS1 family. (740 aa)
KLLA0_D17160gSmall nuclear ribonucleoprotein Sm D3. (100 aa)
CWC15Pre-mRNA-splicing factor CWC15; Involved in pre-mRNA splicing. (187 aa)
KLLA0_D14927gKLLA0D14927p. (507 aa)
KLLA0_D14883gKLLA0D14883p. (467 aa)
KLLA0_D13420gKLLA0D13420p. (166 aa)
KLLA0_D09526gKLLA0D09526p. (217 aa)
KLLA0_D09284gSmall nuclear ribonucleoprotein Sm D2. (110 aa)
KLLA0_D07678gSmall nuclear ribonucleoprotein G. (73 aa)
KLLA0_D04466gKLLA0D04466p. (385 aa)
KLLA0_D03883gKLLA0D03883p. (491 aa)
KLLA0_D03795gKLLA0D03795p. (234 aa)
KLLA0_D02728gKLLA0D02728p. (667 aa)
CWC24Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing. (229 aa)
SNU71U1 small nuclear ribonucleoprotein component SNU71; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity). (568 aa)
KLLA0_C17798gKLLA0C17798p. (2149 aa)
KLLA0_C15675gKLLA0C15675p. (111 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (539 aa)
CWC2Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (337 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.