STRINGSTRING
LSM4 LSM4 KLLA0_F24662g KLLA0_F24662g KLLA0_F22473g KLLA0_F22473g CWC26 CWC26 SPP381 SPP381 SLT11 SLT11 KLLA0_F18018g KLLA0_F18018g CLF1 CLF1 KLLA0_F17523g KLLA0_F17523g ISY1 ISY1 KLLA0_F14861g KLLA0_F14861g SLU7 SLU7 KLLA0_F14344g KLLA0_F14344g PRP46 PRP46 KLLA0_F09449g KLLA0_F09449g KLLA0_F09207g KLLA0_F09207g KLLA0_F07249g KLLA0_F07249g KLLA0_F06204g KLLA0_F06204g KLLA0_F04191g KLLA0_F04191g PRP45 PRP45 SNU13 SNU13 SUB2 SUB2 KLLA0_E21187g KLLA0_E21187g KLLA0_E18239g KLLA0_E18239g KLLA0_E04929g KLLA0_E04929g SYF2 SYF2 LSM6 LSM6 KLLA0_E01409g KLLA0_E01409g KLLA0_D17160g KLLA0_D17160g CWC15 CWC15 KLLA0_D14883g KLLA0_D14883g KLLA0_D09284g KLLA0_D09284g KLLA0_D07678g KLLA0_D07678g KLLA0_D03883g KLLA0_D03883g KLLA0_D03795g KLLA0_D03795g CWC24 CWC24 KLLA0_C18172g KLLA0_C18172g SNU71 SNU71 KLLA0_C17798g KLLA0_C17798g KLLA0_C15675g KLLA0_C15675g CWC2 CWC2 KLLA0_C15169g KLLA0_C15169g KLLA0_C14388g KLLA0_C14388g KLLA0_C14025g KLLA0_C14025g KLLA0_C08800g KLLA0_C08800g KLLA0_C08019g KLLA0_C08019g CEF1 CEF1 SPP2 SPP2 KLLA0_C03322g KLLA0_C03322g CWC25 CWC25 CWC23 CWC23 KLLA0_B11594g KLLA0_B11594g KLLA0_B10472g KLLA0_B10472g CWC21 CWC21 KLLA0_B08976g KLLA0_B08976g KLLA0_B06369g KLLA0_B06369g KLLA0_B02156g KLLA0_B02156g KLLA0_B00627g KLLA0_B00627g KLLA0_B00561g KLLA0_B00561g KLLA0_A09537g KLLA0_A09537g RSE1 RSE1 KLLA0_A08019g KLLA0_A08019g KLLA0_A07733g KLLA0_A07733g KLLA0_A05280g KLLA0_A05280g KLLA0_A02299g KLLA0_A02299g SYF1 SYF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (183 aa)
KLLA0_F24662gKLLA0F24662p. (530 aa)
KLLA0_F22473gKLLA0F22473p. (253 aa)
CWC26Pre-mRNA-splicing factor CWC26; Involved in pre-mRNA splicing. (268 aa)
SPP381Pre-mRNA-splicing factor SPP381; Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity). (262 aa)
SLT11Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). (302 aa)
KLLA0_F18018gKLLA0F18018p. (459 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)
KLLA0_F17523gKLLA0F17523p. (855 aa)
ISY1Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing. (237 aa)
KLLA0_F14861gKLLA0F14861p. (589 aa)
SLU7Pre-mRNA-splicing factor SLU7; Involved in pre-mRNA splicing. (341 aa)
KLLA0_F14344gKLLA0F14344p. (284 aa)
PRP46Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M. (434 aa)
KLLA0_F09449gKLLA0F09449p; Belongs to the chaperonin (HSP60) family. (574 aa)
KLLA0_F09207gU6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
KLLA0_F07249gKLLA0F07249p. (256 aa)
KLLA0_F06204gKLLA0F06204p. (877 aa)
KLLA0_F04191gKLLA0F04191p. (885 aa)
PRP45Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing. (430 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (437 aa)
KLLA0_E21187gKLLA0E21187p. (429 aa)
KLLA0_E18239gKLLA0E18239p. (571 aa)
KLLA0_E04929gKLLA0E04929p. (112 aa)
SYF2Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing. (221 aa)
LSM6U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (80 aa)
KLLA0_E01409gKLLA0E01409p. (186 aa)
KLLA0_D17160gSmall nuclear ribonucleoprotein Sm D3. (100 aa)
CWC15Pre-mRNA-splicing factor CWC15; Involved in pre-mRNA splicing. (187 aa)
KLLA0_D14883gKLLA0D14883p. (467 aa)
KLLA0_D09284gSmall nuclear ribonucleoprotein Sm D2. (110 aa)
KLLA0_D07678gSmall nuclear ribonucleoprotein G. (73 aa)
KLLA0_D03883gKLLA0D03883p. (491 aa)
KLLA0_D03795gKLLA0D03795p. (234 aa)
CWC24Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing. (229 aa)
KLLA0_C18172gKLLA0C18172p. (152 aa)
SNU71U1 small nuclear ribonucleoprotein component SNU71; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity). (568 aa)
KLLA0_C17798gKLLA0C17798p. (2149 aa)
KLLA0_C15675gKLLA0C15675p. (111 aa)
CWC2Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (337 aa)
KLLA0_C15169gKLLA0C15169p. (549 aa)
KLLA0_C14388gKLLA0C14388p. (203 aa)
KLLA0_C14025gKLLA0C14025p. (529 aa)
KLLA0_C08800gKLLA0C08800p. (157 aa)
KLLA0_C08019gKLLA0C08019p. (301 aa)
CEF1Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control. (543 aa)
SPP2Pre-mRNA-splicing factor SPP2; Involved in spliceosome maturation and the first step of pre- mRNA splicing. (189 aa)
KLLA0_C03322gKLLA0C03322p. (385 aa)
CWC25Pre-mRNA-splicing factor CWC25; Involved in pre-mRNA splicing. (206 aa)
CWC23Pre-mRNA-splicing factor CWC23; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). (270 aa)
KLLA0_B11594gKLLA0B11594p. (114 aa)
KLLA0_B10472gNuclear cap-binding protein subunit 2. (198 aa)
CWC21Pre-mRNA-splicing factor CWC21; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). (113 aa)
KLLA0_B08976gKLLA0B08976p. (305 aa)
KLLA0_B06369gKLLA0B06369p. (271 aa)
KLLA0_B02156gKLLA0B02156p. (242 aa)
KLLA0_B00627gKLLA0B00627p. (191 aa)
KLLA0_B00561gKLLA0B00561p. (767 aa)
KLLA0_A09537gKLLA0A09537p. (954 aa)
RSE1Pre-mRNA-splicing factor RSE1; Involved in pre-mRNA splicing and cell cycle control. (1269 aa)
KLLA0_A08019gKLLA0A08019p. (615 aa)
KLLA0_A07733gKLLA0A07733p. (1064 aa)
KLLA0_A05280gKLLA0A05280p. (2411 aa)
KLLA0_A02299gSmall nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
SYF1Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing and cell cycle progression. (798 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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