STRINGSTRING
DBP10 DBP10 KLLA0_E17535g KLLA0_E17535g KLLA0_B06622g KLLA0_B06622g LSM4 LSM4 KLLA0_F18568g KLLA0_F18568g CBF5 CBF5 RLP7 RLP7 ERB1 ERB1 KLLA0_F26224g KLLA0_F26224g KLLA0_F26070g KLLA0_F26070g NAT10 NAT10 KLLA0_F23760g KLLA0_F23760g KLLA0_F23650g KLLA0_F23650g KLLA0_F23243g KLLA0_F23243g KLLA0_F21846g KLLA0_F21846g KLLA0_F21670g KLLA0_F21670g GAR1 GAR1 UTP10 UTP10 RPB5 RPB5 KLLA0_F20119g KLLA0_F20119g KLLA0_F19888g KLLA0_F19888g KLLA0_F18722g KLLA0_F18722g KLLA0_F18304g KLLA0_F18304g KLLA0_F17435g KLLA0_F17435g KLLA0_F17237g KLLA0_F17237g KLLA0_F16467g KLLA0_F16467g KLLA0_F16280g KLLA0_F16280g DRS1 DRS1 KLLA0_F15598g KLLA0_F15598g KLLA0_F15180g KLLA0_F15180g DBP7 DBP7 KLLA0_F13772g KLLA0_F13772g KLLA0_F13508g KLLA0_F13508g RSA3 RSA3 KLLA0_F13244g KLLA0_F13244g KLLA0_F13222g KLLA0_F13222g KLLA0_F12540g KLLA0_F12540g KLLA0_F12496g KLLA0_F12496g ARX1 ARX1 KLLA0_F11506g KLLA0_F11506g KLLA0_F11253g KLLA0_F11253g KLLA0_F11000g KLLA0_F11000g NSA1 NSA1 KLLA0_F10241g KLLA0_F10241g KLLA0_F09207g KLLA0_F09207g KLLA0_F09097g KLLA0_F09097g NOP58 NOP58 KLLA0_F08206g KLLA0_F08206g NOP12 NOP12 DBP6 DBP6 KLLA0_F06710g KLLA0_F06710g KLLA0_F06622g KLLA0_F06622g KLLA0_F05962g KLLA0_F05962g RRT14 RRT14 KLLA0_F03399g KLLA0_F03399g KLLA0_F03124g KLLA0_F03124g FEN1 FEN1 KLLA0_F02453g KLLA0_F02453g KLLA0_F02321g KLLA0_F02321g KLLA0_F02211g KLLA0_F02211g KLLA0_F02013g KLLA0_F02013g KLLA0_F01364g KLLA0_F01364g KLLA0_F01122g KLLA0_F01122g KLLA0_F00484g KLLA0_F00484g KLLA0_E24663g KLLA0_E24663g NOG1 NOG1 KLLA0_E22881g KLLA0_E22881g SNU13 SNU13 KLLA0_E21869g KLLA0_E21869g KLLA0_E21165g KLLA0_E21165g KLLA0_E21121g KLLA0_E21121g KLLA0_E18151g KLLA0_E18151g KLLA0_E17799g KLLA0_E17799g KLLA0_E17425g KLLA0_E17425g KLLA0_E16457g KLLA0_E16457g KLLA0_E15995g KLLA0_E15995g SPB4 SPB4 LOC1 LOC1 KLLA0_E13729g KLLA0_E13729g NOP9 NOP9 KLLA0_E13641g KLLA0_E13641g NSA2 NSA2 KLLA0_E13047g KLLA0_E13047g KLLA0_E12739g KLLA0_E12739g KLLA0_E12519g KLLA0_E12519g KLLA0_E12145g KLLA0_E12145g CGR1 CGR1 KLLA0_E10671g KLLA0_E10671g KLLA0_E10495g KLLA0_E10495g KLLA0_E10209g KLLA0_E10209g KLLA0_E10099g KLLA0_E10099g RLP24 RLP24 KLLA0_E09219g KLLA0_E09219g KLLA0_E08515g KLLA0_E08515g KLLA0_E08383g KLLA0_E08383g KLLA0_E08361g KLLA0_E08361g UTP25 UTP25 KLLA0_E07833g KLLA0_E07833g TRM13 TRM13 KLLA0_E07393g KLLA0_E07393g KLLA0_E05149g KLLA0_E05149g KLLA0_E04665g KLLA0_E04665g KLLA0_E04247g KLLA0_E04247g LSM6 LSM6 KLLA0_E02091g KLLA0_E02091g KLLA0_E01937g KLLA0_E01937g KLLA0_E01277g KLLA0_E01277g KLLA0_E00837g KLLA0_E00837g GRC3 GRC3 KLLA0_E00551g KLLA0_E00551g KLLA0_D19701g KLLA0_D19701g KLLA0_D19602g KLLA0_D19602g KLLA0_D19448g KLLA0_D19448g KLLA0_D18029g KLLA0_D18029g KLLA0_D16940g KLLA0_D16940g KLLA0_D16390g KLLA0_D16390g KLLA0_D16137g KLLA0_D16137g NOP7 NOP7 KLLA0_D14993g KLLA0_D14993g MRD1 MRD1 KLLA0_D14861g KLLA0_D14861g KLLA0_D14806g KLLA0_D14806g NOP16 NOP16 KLLA0_D13618g KLLA0_D13618g KLLA0_D13222g KLLA0_D13222g KLLA0_D12870g KLLA0_D12870g KLLA0_D12254g KLLA0_D12254g KLLA0_D10351g KLLA0_D10351g KLLA0_D09757g KLLA0_D09757g KLLA0_D09735g KLLA0_D09735g KLLA0_D09625g KLLA0_D09625g DBP4 DBP4 KLLA0_D09482g KLLA0_D09482g KLLA0_D08459g KLLA0_D08459g KLLA0_D08393g KLLA0_D08393g KLLA0_D08206g KLLA0_D08206g KLLA0_D08008g KLLA0_D08008g KLLA0_D07139g KLLA0_D07139g KLLA0_D06699g KLLA0_D06699g KLLA0_D06677g KLLA0_D06677g KLLA0_D05995g KLLA0_D05995g FYV7 FYV7 KLLA0_D03234g KLLA0_D03234g TIF6 TIF6 KLLA0_D01815g KLLA0_D01815g KLLA0_D01309g KLLA0_D01309g KLLA0_D01023g KLLA0_D01023g KLLA0_D00792g KLLA0_D00792g ESF2 ESF2 NOG2 NOG2 KLLA0_C18381g KLLA0_C18381g KLLA0_C17578g KLLA0_C17578g KLLA0_C17512g KLLA0_C17512g ROK1 ROK1 NOP10 NOP10 KLLA0_C16401g KLLA0_C16401g NOP14 NOP14 SLX9 SLX9 DBP3 DBP3 KLLA0_C15345g KLLA0_C15345g KLLA0_C14718g KLLA0_C14718g RRP3 RRP3 PXR1 PXR1 KLLA0_C12199g KLLA0_C12199g KLLA0_C11847g KLLA0_C11847g KLLA0_C11495g KLLA0_C11495g BMT2 BMT2 MAK5 MAK5 KLLA0_C11099g KLLA0_C11099g BFR2 BFR2 KLLA0_C09394g KLLA0_C09394g KLLA0_C09262g KLLA0_C09262g KLLA0_C08976g KLLA0_C08976g KLLA0_C08547g KLLA0_C08547g YTM1 YTM1 KLLA0_C07359g KLLA0_C07359g RRP36 RRP36 KLLA0_C06633g KLLA0_C06633g PNO1 PNO1 KLLA0_C06116g KLLA0_C06116g KLLA0_C05984g KLLA0_C05984g KLLA0_C05852g KLLA0_C05852g DBP9 DBP9 KLLA0_C04389g KLLA0_C04389g KLLA0_C03520g KLLA0_C03520g KLLA0_C02959g KLLA0_C02959g KLLA0_C01914g KLLA0_C01914g KLLA0_C01408g KLLA0_C01408g SPB1 SPB1 KLLA0_C00506g KLLA0_C00506g KLLA0_B13860g KLLA0_B13860g KLLA0_B13563g KLLA0_B13563g KLLA0_B13046g KLLA0_B13046g KLLA0_B12738g KLLA0_B12738g KLLA0_B11792g KLLA0_B11792g KLLA0_B11077g KLLA0_B11077g KLLA0_B10890g KLLA0_B10890g JIP5 JIP5 KLLA0_B08239g KLLA0_B08239g KLLA0_B06303g KLLA0_B06303g KLLA0_B06116g KLLA0_B06116g KLLA0_B05973g KLLA0_B05973g KLLA0_B05555g KLLA0_B05555g KLLA0_B05203g KLLA0_B05203g FPR3 FPR3 KLLA0_B04180g KLLA0_B04180g KLLA0_B03476g KLLA0_B03476g KLLA0_B02827g KLLA0_B02827g KLLA0_B02266g KLLA0_B02266g KLLA0_B02068g KLLA0_B02068g KLLA0_B01518g KLLA0_B01518g KLLA0_A10835g KLLA0_A10835g FAL1 FAL1 EFG1 EFG1 HAS1 HAS1 KLLA0_A07931g KLLA0_A07931g KLLA0_A07018g KLLA0_A07018g KLLA0_A06710g KLLA0_A06710g KLLA0_A05973g KLLA0_A05973g KLLA0_A05753g KLLA0_A05753g KLLA0_A05456g KLLA0_A05456g DBP8 DBP8 KLLA0_A05181g KLLA0_A05181g KLLA0_A04818g KLLA0_A04818g KLLA0_A04653g KLLA0_A04653g KLLA0_A04037g KLLA0_A04037g KLLA0_A02079g KLLA0_A02079g ACS2 ACS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBP10ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (973 aa)
KLLA0_E17535gRepressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (329 aa)
KLLA0_B06622gKLLA0B06622p. (508 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (183 aa)
KLLA0_F18568gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (112 aa)
CBF5H/ACA ribonucleoprotein complex subunit CBF5; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridy [...] (474 aa)
RLP7Ribosome biogenesis protein RLP7; Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (318 aa)
ERB1Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (791 aa)
KLLA0_F26224gKLLA0F26224p. (732 aa)
KLLA0_F26070gKLLA0F26070p. (447 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1055 aa)
KLLA0_F23760gKLLA0F23760p. (127 aa)
KLLA0_F23650gKLLA0F23650p. (312 aa)
KLLA0_F23243gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1653 aa)
KLLA0_F21846gKLLA0F21846p. (376 aa)
KLLA0_F21670gKLLA0F21670p. (292 aa)
GAR1H/ACA ribonucleoprotein complex subunit GAR1; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA. (219 aa)
UTP10U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1774 aa)
RPB5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (215 aa)
KLLA0_F20119gCondensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1085 aa)
KLLA0_F19888gMidasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4915 aa)
KLLA0_F18722gKLLA0F18722p. (270 aa)
KLLA0_F18304gKLLA0F18304p. (236 aa)
KLLA0_F17435gKLLA0F17435p. (1271 aa)
KLLA0_F17237gKLLA0F17237p. (523 aa)
KLLA0_F16467gKLLA0F16467p; Belongs to the protein kinase superfamily. (340 aa)
KLLA0_F16280g20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (472 aa)
DRS1ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (748 aa)
KLLA0_F15598gKLLA0F15598p. (478 aa)
KLLA0_F15180gKLLA0F15180p. (524 aa)
DBP7ATP-dependent RNA helicase DBP7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (740 aa)
KLLA0_F13772gKLLA0F13772p. (520 aa)
KLLA0_F13508gU3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (249 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (203 aa)
KLLA0_F13244gKLLA0F13244p. (814 aa)
KLLA0_F13222gKLLA0F13222p. (984 aa)
KLLA0_F12540gKLLA0F12540p. (125 aa)
KLLA0_F12496gSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (311 aa)
ARX1Probable metalloprotease ARX1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (571 aa)
KLLA0_F11506gRibosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (444 aa)
KLLA0_F11253gKLLA0F11253p. (676 aa)
KLLA0_F11000gKLLA0F11000p. (555 aa)
NSA1Ribosome biogenesis protein NSA1; Involved in the biogenesis of the 60S ribosomal subunit. (436 aa)
KLLA0_F10241gKLLA0F10241p. (176 aa)
KLLA0_F09207gU6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
KLLA0_F09097gKLLA0F09097p; Belongs to the MT-A70-like family. (524 aa)
NOP58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (511 aa)
KLLA0_F08206gKLLA0F08206p. (838 aa)
NOP12Nucleolar protein 12; Involved in pre-25S rRNA processing; Belongs to the RRM RBM34 family. (462 aa)
DBP6ATP-dependent RNA helicase DBP6; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (630 aa)
KLLA0_F06710gKLLA0F06710p. (1096 aa)
KLLA0_F06622gKLLA0F06622p. (478 aa)
KLLA0_F05962gKLLA0F05962p. (267 aa)
RRT14Regulator of rDNA transcription 14; Involved in ribosome biogenesis, probably through modulation of rDNA transcription; Belongs to the RRT14 family. (201 aa)
KLLA0_F03399gKLLA0F03399p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (619 aa)
KLLA0_F03124gKLLA0F03124p. (433 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
KLLA0_F02453gKLLA0F02453p. (214 aa)
KLLA0_F02321gKLLA0F02321p. (287 aa)
KLLA0_F02211gRibonuclease P protein subunit. (274 aa)
KLLA0_F02013gKLLA0F02013p. (566 aa)
KLLA0_F01364gKLLA0F01364p. (1073 aa)
KLLA0_F01122gKLLA0F01122p. (712 aa)
KLLA0_F00484gKLLA0F00484p. (198 aa)
KLLA0_E24663gKLLA0E24663p. (136 aa)
NOG1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (643 aa)
KLLA0_E22881gKLLA0E22881p. (110 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
KLLA0_E21869gCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (260 aa)
KLLA0_E21165gKLLA0E21165p. (627 aa)
KLLA0_E21121gSerine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (526 aa)
KLLA0_E18151gKLLA0E18151p. (1696 aa)
KLLA0_E17799gKLLA0E17799p. (298 aa)
KLLA0_E17425gKLLA0E17425p. (2493 aa)
KLLA0_E16457gKLLA0E16457p. (96 aa)
KLLA0_E15995gKLLA0E15995p. (183 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (596 aa)
LOC160S ribosomal subunit assembly/export protein LOC1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (207 aa)
KLLA0_E13729gKLLA0E13729p. (483 aa)
NOP9Nucleolar protein 9; RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity); Belongs to the NOP9 family. (668 aa)
KLLA0_E13641gKLLA0E13641p. (395 aa)
NSA2Ribosome biogenesis protein NSA2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (261 aa)
KLLA0_E13047gKLLA0E13047p. (368 aa)
KLLA0_E12739gKLLA0E12739p. (437 aa)
KLLA0_E12519gKLLA0E12519p. (1006 aa)
KLLA0_E12145gKLLA0E12145p; Belongs to the protein kinase superfamily. (455 aa)
CGR1rRNA-processing protein CGR1; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Belongs to the CGR1 family. (121 aa)
KLLA0_E10671gKLLA0E10671p. (862 aa)
KLLA0_E10495gKLLA0E10495p. (138 aa)
KLLA0_E10209gKLLA0E10209p. (84 aa)
KLLA0_E10099gKLLA0E10099p. (233 aa)
RLP24Ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles. (198 aa)
KLLA0_E09219gKLLA0E09219p. (264 aa)
KLLA0_E08515gKLLA0E08515p. (323 aa)
KLLA0_E08383gHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (704 aa)
KLLA0_E08361gKLLA0E08361p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (491 aa)
UTP25U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (704 aa)
KLLA0_E07833gKLLA0E07833p. (283 aa)
TRM13tRNA:m(4)X modification enzyme TRM13; tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). (434 aa)
KLLA0_E07393gKLLA0E07393p. (588 aa)
KLLA0_E05149gKLLA0E05149p. (787 aa)
KLLA0_E04665gKLLA0E04665p. (647 aa)
KLLA0_E04247gKLLA0E04247p; Belongs to the protein kinase superfamily. (373 aa)
LSM6U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (80 aa)
KLLA0_E02091gKLLA0E02091p. (240 aa)
KLLA0_E01937gKLLA0E01937p. (484 aa)
KLLA0_E01277gKLLA0E01277p. (266 aa)
KLLA0_E00837gKLLA0E00837p. (814 aa)
GRC3Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (631 aa)
KLLA0_E00551gKLLA0E00551p. (242 aa)
KLLA0_D19701gKLLA0D19701p. (297 aa)
KLLA0_D19602gKLLA0D19602p. (620 aa)
KLLA0_D19448gKLLA0D19448p. (817 aa)
KLLA0_D18029gKLLA0D18029p. (244 aa)
KLLA0_D16940gKLLA0D16940p. (540 aa)
KLLA0_D16390gKLLA0D16390p. (936 aa)
KLLA0_D16137gKLLA0D16137p. (341 aa)
NOP7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (605 aa)
KLLA0_D14993gKLLA0D14993p. (225 aa)
MRD1Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (878 aa)
KLLA0_D14861gKLLA0D14861p. (334 aa)
KLLA0_D14806gU3 small nucleolar RNA-associated protein 22. (1212 aa)
NOP16Nucleolar protein 16; Involved in the biogenesis of the 60S ribosomal subunit. (239 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
KLLA0_D13222gKLLA0D13222p. (736 aa)
KLLA0_D12870gSignal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (584 aa)
KLLA0_D12254gKLLA0D12254p. (513 aa)
KLLA0_D10351gKLLA0D10351p. (859 aa)
KLLA0_D09757gU3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (608 aa)
KLLA0_D09735gNucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (662 aa)
KLLA0_D09625gKLLA0D09625p. (245 aa)
DBP4ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (770 aa)
KLLA0_D09482gKLLA0D09482p; Belongs to the cyclin family. (323 aa)
KLLA0_D08459gKLLA0D08459p; Belongs to the peptidase C19 family. (750 aa)
KLLA0_D08393gKLLA0D08393p. (220 aa)
KLLA0_D08206gKLLA0D08206p. (391 aa)
KLLA0_D08008gKLLA0D08008p. (70 aa)
KLLA0_D07139gDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
KLLA0_D06699gKLLA0D06699p. (70 aa)
KLLA0_D06677gKLLA0D06677p. (851 aa)
KLLA0_D05995gKLLA0D05995p. (303 aa)
FYV7rRNA-processing protein FYV7; Involved in the processing of the 20S pre-rRNA. Belongs to the FYV7 family. (144 aa)
KLLA0_D03234gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
KLLA0_D01815gKLLA0D01815p. (356 aa)
KLLA0_D01309gKLLA0D01309p. (744 aa)
KLLA0_D01023gKLLA0D01023p. (268 aa)
KLLA0_D00792gKLLA0D00792p. (1020 aa)
ESF2Pre-rRNA-processing protein ESF2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (293 aa)
NOG2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (513 aa)
KLLA0_C18381gTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (861 aa)
KLLA0_C17578gKLLA0C17578p. (1525 aa)
KLLA0_C17512gDNA helicase; Belongs to the MCM family. (892 aa)
ROK1ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (579 aa)
NOP10H/ACA ribonucleoprotein complex subunit NOP10; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA. (57 aa)
KLLA0_C16401gKLLA0C16401p. (612 aa)
NOP14Probable nucleolar complex protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (837 aa)
SLX9Ribosome biogenesis protein SLX9; Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks (By similarity). (198 aa)
DBP3ATP-dependent RNA helicase DBP3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (504 aa)
KLLA0_C15345gRibonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (149 aa)
KLLA0_C14718gKLLA0C14718p. (285 aa)
RRP3ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (487 aa)
PXR1Protein PXR1; Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase; Belongs to the PINX1 family. (271 aa)
KLLA0_C12199gKLLA0C12199p. (198 aa)
KLLA0_C11847gRibosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family. (377 aa)
KLLA0_C11495gKLLA0C11495p. (445 aa)
BMT225S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family. (354 aa)
MAK5ATP-dependent RNA helicase MAK5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (796 aa)
KLLA0_C11099gKLLA0C11099p. (305 aa)
BFR2Protein BFR2. (526 aa)
KLLA0_C09394gKLLA0C09394p. (1184 aa)
KLLA0_C09262gKLLA0C09262p. (558 aa)
KLLA0_C08976gKLLA0C08976p. (911 aa)
KLLA0_C08547gKLLA0C08547p. (515 aa)
YTM1Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (444 aa)
KLLA0_C07359gtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (431 aa)
RRP36rRNA biogenesis protein RRP36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (332 aa)
KLLA0_C06633gKLLA0C06633p. (631 aa)
PNO1Pre-rRNA-processing protein PNO1; Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity). (274 aa)
KLLA0_C06116gDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (785 aa)
KLLA0_C05984gKLLA0C05984p. (364 aa)
KLLA0_C05852gKLLA0C05852p. (482 aa)
DBP9ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (594 aa)
KLLA0_C04389gKLLA0C04389p. (335 aa)
KLLA0_C03520gKLLA0C03520p. (379 aa)
KLLA0_C02959gKLLA0C02959p. (412 aa)
KLLA0_C01914gKLLA0C01914p. (252 aa)
KLLA0_C01408gKLLA0C01408p. (326 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
KLLA0_C00506gKRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (330 aa)
KLLA0_B13860gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (160 aa)
KLLA0_B13563gRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
KLLA0_B13046gRibosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (204 aa)
KLLA0_B12738gKLLA0B12738p. (658 aa)
KLLA0_B11792gKLLA0B11792p. (187 aa)
KLLA0_B11077gKLLA0B11077p. (567 aa)
KLLA0_B10890gKLLA0B10890p. (521 aa)
JIP5WD repeat-containing protein JIP5. (525 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
KLLA0_B06303gDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1203 aa)
KLLA0_B06116gKLLA0B06116p. (1051 aa)
KLLA0_B05973gKLLA0B05973p. (153 aa)
KLLA0_B05555gKLLA0B05555p. (1997 aa)
KLLA0_B05203gKLLA0B05203p. (83 aa)
FPR3FK506-binding protein 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily. (418 aa)
KLLA0_B04180gKLLA0B04180p. (539 aa)
KLLA0_B03476gKLLA0B03476p. (158 aa)
KLLA0_B02827gKLLA0B02827p. (942 aa)
KLLA0_B02266g60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
KLLA0_B02068gKLLA0B02068p. (1167 aa)
KLLA0_B01518gKLLA0B01518p. (454 aa)
KLLA0_A10835gKLLA0A10835p; Belongs to the RNR ribonuclease family. (1008 aa)
FAL1ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (398 aa)
EFG1rRNA-processing protein EFG1; Involved in rRNA processing; Belongs to the EFG1 family. (228 aa)
HAS1ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (497 aa)
KLLA0_A07931gKLLA0A07931p. (344 aa)
KLLA0_A07018gKLLA0A07018p. (189 aa)
KLLA0_A06710gKLLA0A06710p. (423 aa)
KLLA0_A05973gKLLA0A05973p. (194 aa)
KLLA0_A05753gKLLA0A05753p. (270 aa)
KLLA0_A05456gProtein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (759 aa)
DBP8ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (435 aa)
KLLA0_A05181gKLLA0A05181p. (197 aa)
KLLA0_A04818gCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (277 aa)
KLLA0_A04653gKLLA0A04653p. (700 aa)
KLLA0_A04037gProtein MAK16; Belongs to the MAK16 family. (302 aa)
KLLA0_A02079gKLLA0A02079p. (243 aa)
ACS2Acetyl-coenzyme A synthetase 2. (684 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
Server load: low (20%) [HD]