STRINGSTRING
SQS1 SQS1 KLLA0_E00837g KLLA0_E00837g KLLA0_E04247g KLLA0_E04247g KLLA0_E04665g KLLA0_E04665g KLLA0_E05149g KLLA0_E05149g KLLA0_E07393g KLLA0_E07393g KLLA0_E07833g KLLA0_E07833g UTP25 UTP25 RLP24 RLP24 KLLA0_E12519g KLLA0_E12519g NSA2 NSA2 KLLA0_E13641g KLLA0_E13641g NOP9 NOP9 KLLA0_E13729g KLLA0_E13729g LOC1 LOC1 SPB4 SPB4 KLLA0_E15995g KLLA0_E15995g KLLA0_E17425g KLLA0_E17425g KLLA0_E17799g KLLA0_E17799g KLLA0_D06677g KLLA0_D06677g KLLA0_D08206g KLLA0_D08206g KLLA0_D08305g KLLA0_D08305g KLLA0_D08393g KLLA0_D08393g DBP4 DBP4 KLLA0_D09735g KLLA0_D09735g KLLA0_D09757g KLLA0_D09757g KLLA0_D10351g KLLA0_D10351g KLLA0_D12254g KLLA0_D12254g KLLA0_D13222g KLLA0_D13222g KLLA0_D05621g KLLA0_D05621g FYV7 FYV7 KLLA0_D03168g KLLA0_D03168g TIF6 TIF6 KLLA0_D01023g KLLA0_D01023g KLLA0_D00792g KLLA0_D00792g ESF2 ESF2 NOG2 NOG2 ROK1 ROK1 KLLA0_C16401g KLLA0_C16401g NOP14 NOP14 SLX9 SLX9 DBP3 DBP3 RRP3 RRP3 KLLA0_C12331g KLLA0_C12331g KLLA0_C11979g KLLA0_C11979g KLLA0_C11495g KLLA0_C11495g BFR2 BFR2 KLLA0_C09262g KLLA0_C09262g KLLA0_C08976g KLLA0_C08976g YTM1 YTM1 KLLA0_F01122g KLLA0_F01122g KLLA0_B11077g KLLA0_B11077g KLLA0_B10934g KLLA0_B10934g KLLA0_B10890g KLLA0_B10890g KLLA0_B08239g KLLA0_B08239g KLLA0_B06116g KLLA0_B06116g KLLA0_B05555g KLLA0_B05555g KLLA0_B04180g KLLA0_B04180g KLLA0_B03234g KLLA0_B03234g KLLA0_B02827g KLLA0_B02827g KLLA0_B02068g KLLA0_B02068g KLLA0_B01518g KLLA0_B01518g FAL1 FAL1 EFG1 EFG1 HAS1 HAS1 KLLA0_A07018g KLLA0_A07018g KLLA0_A06710g KLLA0_A06710g KLLA0_A05753g KLLA0_A05753g DBP8 DBP8 KLLA0_F01727g KLLA0_F01727g KLLA0_F02013g KLLA0_F02013g KLLA0_F03399g KLLA0_F03399g KLLA0_F06622g KLLA0_F06622g DBP6 DBP6 NOP12 NOP12 NOP58 NOP58 KLLA0_F09812g KLLA0_F09812g NSA1 NSA1 ARX1 ARX1 KLLA0_F13244g KLLA0_F13244g RSA3 RSA3 KLLA0_F13508g KLLA0_F13508g KLLA0_F13772g KLLA0_F13772g KLLA0_F15598g KLLA0_F15598g DRS1 DRS1 KLLA0_F16280g KLLA0_F16280g KLLA0_F16467g KLLA0_F16467g KLLA0_F17435g KLLA0_F17435g KLLA0_F19888g KLLA0_F19888g UTP10 UTP10 KLLA0_F21670g KLLA0_F21670g KLLA0_F21846g KLLA0_F21846g KLLA0_A05181g KLLA0_A05181g KLLA0_A04818g KLLA0_A04818g KLLA0_A04653g KLLA0_A04653g KLLA0_A04037g KLLA0_A04037g RRP36 RRP36 KLLA0_C06633g KLLA0_C06633g KLLA0_C05984g KLLA0_C05984g KLLA0_C04389g KLLA0_C04389g KLLA0_C01914g KLLA0_C01914g KLLA0_C01408g KLLA0_C01408g SPB1 SPB1 KLLA0_C00506g KLLA0_C00506g KLLA0_B13563g KLLA0_B13563g KLLA0_B13046g KLLA0_B13046g KLLA0_E21165g KLLA0_E21165g KLLA0_E21869g KLLA0_E21869g SNU13 SNU13 NOG1 NOG1 KLLA0_F00484g KLLA0_F00484g KLLA0_F23650g KLLA0_F23650g NAT10 NAT10 DBP10 DBP10 KLLA0_F26224g KLLA0_F26224g ERB1 ERB1 KLLA0_F27269g KLLA0_F27269g DIM1 DIM1 RPL25 RPL25 RLP7 RLP7 KLLA0_D13618g KLLA0_D13618g NOP16 NOP16 KLLA0_D14806g KLLA0_D14806g MRD1 MRD1 NOP7 NOP7 KLLA0_D16390g KLLA0_D16390g KLLA0_D18029g KLLA0_D18029g
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SQS1Protein SQS1; May be involved in splicing; Belongs to the SQS1 family. (740 aa)
KLLA0_E00837gKLLA0E00837p. (814 aa)
KLLA0_E04247gKLLA0E04247p; Belongs to the protein kinase superfamily. (373 aa)
KLLA0_E04665gKLLA0E04665p. (647 aa)
KLLA0_E05149gKLLA0E05149p. (787 aa)
KLLA0_E07393gKLLA0E07393p. (588 aa)
KLLA0_E07833gKLLA0E07833p. (283 aa)
UTP25U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (704 aa)
RLP24Ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles. (198 aa)
KLLA0_E12519gKLLA0E12519p. (1006 aa)
NSA2Ribosome biogenesis protein NSA2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (261 aa)
KLLA0_E13641gKLLA0E13641p. (395 aa)
NOP9Nucleolar protein 9; RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity); Belongs to the NOP9 family. (668 aa)
KLLA0_E13729gKLLA0E13729p. (483 aa)
LOC160S ribosomal subunit assembly/export protein LOC1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (207 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (596 aa)
KLLA0_E15995gKLLA0E15995p. (183 aa)
KLLA0_E17425gKLLA0E17425p. (2493 aa)
KLLA0_E17799gKLLA0E17799p. (298 aa)
KLLA0_D06677gKLLA0D06677p. (851 aa)
KLLA0_D08206gKLLA0D08206p. (391 aa)
KLLA0_D08305gKLLA0D08305p; Belongs to the universal ribosomal protein uS3 family. (237 aa)
KLLA0_D08393gKLLA0D08393p. (220 aa)
DBP4ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (770 aa)
KLLA0_D09735gNucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (662 aa)
KLLA0_D09757gU3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (608 aa)
KLLA0_D10351gKLLA0D10351p. (859 aa)
KLLA0_D12254gKLLA0D12254p. (513 aa)
KLLA0_D13222gKLLA0D13222p. (736 aa)
KLLA0_D05621gKLLA0D05621p. (167 aa)
FYV7rRNA-processing protein FYV7; Involved in the processing of the 20S pre-rRNA. Belongs to the FYV7 family. (144 aa)
KLLA0_D03168gKLLA0D03168p. (505 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
KLLA0_D01023gKLLA0D01023p. (268 aa)
KLLA0_D00792gKLLA0D00792p. (1020 aa)
ESF2Pre-rRNA-processing protein ESF2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (293 aa)
NOG2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (513 aa)
ROK1ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (579 aa)
KLLA0_C16401gKLLA0C16401p. (612 aa)
NOP14Probable nucleolar complex protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (837 aa)
SLX9Ribosome biogenesis protein SLX9; Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks (By similarity). (198 aa)
DBP3ATP-dependent RNA helicase DBP3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (504 aa)
RRP3ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (487 aa)
KLLA0_C12331gKLLA0C12331p. (662 aa)
KLLA0_C11979gKLLA0C11979p. (261 aa)
KLLA0_C11495gKLLA0C11495p. (445 aa)
BFR2Protein BFR2. (526 aa)
KLLA0_C09262gKLLA0C09262p. (558 aa)
KLLA0_C08976gKLLA0C08976p. (911 aa)
YTM1Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (444 aa)
KLLA0_F01122gKLLA0F01122p. (712 aa)
KLLA0_B11077gKLLA0B11077p. (567 aa)
KLLA0_B10934gKLLA0B10934p. (253 aa)
KLLA0_B10890gKLLA0B10890p. (521 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
KLLA0_B06116gKLLA0B06116p. (1051 aa)
KLLA0_B05555gKLLA0B05555p. (1997 aa)
KLLA0_B04180gKLLA0B04180p. (539 aa)
KLLA0_B03234gKLLA0B03234p. (804 aa)
KLLA0_B02827gKLLA0B02827p. (942 aa)
KLLA0_B02068gKLLA0B02068p. (1167 aa)
KLLA0_B01518gKLLA0B01518p. (454 aa)
FAL1ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (398 aa)
EFG1rRNA-processing protein EFG1; Involved in rRNA processing; Belongs to the EFG1 family. (228 aa)
HAS1ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (497 aa)
KLLA0_A07018gKLLA0A07018p. (189 aa)
KLLA0_A06710gKLLA0A06710p. (423 aa)
KLLA0_A05753gKLLA0A05753p. (270 aa)
DBP8ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (435 aa)
KLLA0_F01727gKLLA0F01727p. (404 aa)
KLLA0_F02013gKLLA0F02013p. (566 aa)
KLLA0_F03399gKLLA0F03399p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (619 aa)
KLLA0_F06622gKLLA0F06622p. (478 aa)
DBP6ATP-dependent RNA helicase DBP6; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (630 aa)
NOP12Nucleolar protein 12; Involved in pre-25S rRNA processing; Belongs to the RRM RBM34 family. (462 aa)
NOP58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (511 aa)
KLLA0_F09812gKLLA0F09812p; Belongs to the universal ribosomal protein uS5 family. (259 aa)
NSA1Ribosome biogenesis protein NSA1; Involved in the biogenesis of the 60S ribosomal subunit. (436 aa)
ARX1Probable metalloprotease ARX1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (571 aa)
KLLA0_F13244gKLLA0F13244p. (814 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (203 aa)
KLLA0_F13508gU3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (249 aa)
KLLA0_F13772gKLLA0F13772p. (520 aa)
KLLA0_F15598gKLLA0F15598p. (478 aa)
DRS1ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (748 aa)
KLLA0_F16280g20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (472 aa)
KLLA0_F16467gKLLA0F16467p; Belongs to the protein kinase superfamily. (340 aa)
KLLA0_F17435gKLLA0F17435p. (1271 aa)
KLLA0_F19888gMidasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4915 aa)
UTP10U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1774 aa)
KLLA0_F21670gKLLA0F21670p. (292 aa)
KLLA0_F21846gKLLA0F21846p. (376 aa)
KLLA0_A05181gKLLA0A05181p. (197 aa)
KLLA0_A04818gCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (277 aa)
KLLA0_A04653gKLLA0A04653p. (700 aa)
KLLA0_A04037gProtein MAK16; Belongs to the MAK16 family. (302 aa)
RRP36rRNA biogenesis protein RRP36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (332 aa)
KLLA0_C06633gKLLA0C06633p. (631 aa)
KLLA0_C05984gKLLA0C05984p. (364 aa)
KLLA0_C04389gKLLA0C04389p. (335 aa)
KLLA0_C01914gKLLA0C01914p. (252 aa)
KLLA0_C01408gKLLA0C01408p. (326 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
KLLA0_C00506gKRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (330 aa)
KLLA0_B13563gRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
KLLA0_B13046gRibosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (204 aa)
KLLA0_E21165gKLLA0E21165p. (627 aa)
KLLA0_E21869gCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (260 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
NOG1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (643 aa)
KLLA0_F00484gKLLA0F00484p. (198 aa)
KLLA0_F23650gKLLA0F23650p. (312 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1055 aa)
DBP10ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (973 aa)
KLLA0_F26224gKLLA0F26224p. (732 aa)
ERB1Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (791 aa)
KLLA0_F27269gKLLA0F27269p. (1216 aa)
DIM1Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (320 aa)
RPL2560S ribosomal protein L25; Belongs to the universal ribosomal protein uL23 family. (142 aa)
RLP7Ribosome biogenesis protein RLP7; Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (318 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
NOP16Nucleolar protein 16; Involved in the biogenesis of the 60S ribosomal subunit. (239 aa)
KLLA0_D14806gU3 small nucleolar RNA-associated protein 22. (1212 aa)
MRD1Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (878 aa)
NOP7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (605 aa)
KLLA0_D16390gKLLA0D16390p. (936 aa)
KLLA0_D18029gKLLA0D18029p. (244 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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