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KLLA0_E01937g KLLA0_E01937g KLLA0_E05061g KLLA0_E05061g KLLA0_E05171g KLLA0_E05171g RLP24 RLP24 KLLA0_E12519g KLLA0_E12519g RAI1 RAI1 NSA2 NSA2 LOC1 LOC1 SPB4 SPB4 ALB1 ALB1 KLLA0_E17799g KLLA0_E17799g REX4 REX4 KLLA0_C18546g KLLA0_C18546g RLP7 RLP7 RPL25 RPL25 ERB1 ERB1 KLLA0_F26070g KLLA0_F26070g DBP10 DBP10 KLLA0_F23650g KLLA0_F23650g KLLA0_F21846g KLLA0_F21846g KLLA0_F21670g KLLA0_F21670g KLLA0_F19888g KLLA0_F19888g RPL3 RPL3 DRS1 DRS1 IPI1 IPI1 DBP7 DBP7 RSA3 RSA3 KLLA0_F11506g KLLA0_F11506g KLLA0_E18151g KLLA0_E18151g NOG1 NOG1 KLLA0_F01122g KLLA0_F01122g KLLA0_F01727g KLLA0_F01727g KLLA0_F03399g KLLA0_F03399g KLLA0_F03663g KLLA0_F03663g KLLA0_F05247g KLLA0_F05247g KLLA0_F06666g KLLA0_F06666g DBP6 DBP6 RAT1 RAT1 NOP12 NOP12 NSA1 NSA1 KLLA0_A04037g KLLA0_A04037g KLLA0_A05456g KLLA0_A05456g KLLA0_A07931g KLLA0_A07931g HAS1 HAS1 KLLA0_B01804g KLLA0_B01804g MRH4 MRH4 KLLA0_B03234g KLLA0_B03234g RIX1 RIX1 KLLA0_B08239g KLLA0_B08239g JIP5 JIP5 KLLA0_B10934g KLLA0_B10934g KLLA0_B13046g KLLA0_B13046g KLLA0_B13563g KLLA0_B13563g SPB1 SPB1 DBP9 DBP9 YTM1 YTM1 KLLA0_C08547g KLLA0_C08547g MAK5 MAK5 KLLA0_C12331g KLLA0_C12331g KLLA0_C14564g KLLA0_C14564g DBP3 DBP3 KLLA0_C17556g KLLA0_C17556g KLLA0_D00792g KLLA0_D00792g TIF6 TIF6 KLLA0_D03168g KLLA0_D03168g KLLA0_D03410g KLLA0_D03410g KLLA0_D05643g KLLA0_D05643g KLLA0_D06941g KLLA0_D06941g IPI3 IPI3 KLLA0_D09735g KLLA0_D09735g KLLA0_D11792g KLLA0_D11792g KLLA0_D13618g KLLA0_D13618g NOP16 NOP16 NOP7 NOP7 KLLA0_D15873g KLLA0_D15873g KLLA0_D16852g KLLA0_D16852g KLLA0_D19602g KLLA0_D19602g GRC3 GRC3 KLLA0_E00837g KLLA0_E00837g
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KLLA0_E01937gKLLA0E01937p. (484 aa)
KLLA0_E05061gKLLA0E05061p. (616 aa)
KLLA0_E05171gKLLA0E05171p. (421 aa)
RLP24Ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles. (198 aa)
KLLA0_E12519gKLLA0E12519p. (1006 aa)
RAI1Decapping nuclease RAI1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (384 aa)
NSA2Ribosome biogenesis protein NSA2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (261 aa)
LOC160S ribosomal subunit assembly/export protein LOC1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (207 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (596 aa)
ALB1Ribosome biogenesis protein ALB1; Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (160 aa)
KLLA0_E17799gKLLA0E17799p. (298 aa)
REX4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (294 aa)
KLLA0_C18546gKLLA0C18546p. (132 aa)
RLP7Ribosome biogenesis protein RLP7; Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (318 aa)
RPL2560S ribosomal protein L25; Belongs to the universal ribosomal protein uL23 family. (142 aa)
ERB1Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (791 aa)
KLLA0_F26070gKLLA0F26070p. (447 aa)
DBP10ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (973 aa)
KLLA0_F23650gKLLA0F23650p. (312 aa)
KLLA0_F21846gKLLA0F21846p. (376 aa)
KLLA0_F21670gKLLA0F21670p. (292 aa)
KLLA0_F19888gMidasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4915 aa)
RPL360S ribosomal protein L3. (387 aa)
DRS1ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (748 aa)
IPI1Pre-rRNA-processing protein IPI1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (381 aa)
DBP7ATP-dependent RNA helicase DBP7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (740 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (203 aa)
KLLA0_F11506gRibosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (444 aa)
KLLA0_E18151gKLLA0E18151p. (1696 aa)
NOG1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (643 aa)
KLLA0_F01122gKLLA0F01122p. (712 aa)
KLLA0_F01727gKLLA0F01727p. (404 aa)
KLLA0_F03399gKLLA0F03399p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (619 aa)
KLLA0_F03663gKLLA0F03663p. (368 aa)
KLLA0_F05247gKLLA0F05247p. (120 aa)
KLLA0_F06666gKLLA0F06666p. (648 aa)
DBP6ATP-dependent RNA helicase DBP6; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (630 aa)
RAT15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (992 aa)
NOP12Nucleolar protein 12; Involved in pre-25S rRNA processing; Belongs to the RRM RBM34 family. (462 aa)
NSA1Ribosome biogenesis protein NSA1; Involved in the biogenesis of the 60S ribosomal subunit. (436 aa)
KLLA0_A04037gProtein MAK16; Belongs to the MAK16 family. (302 aa)
KLLA0_A05456gProtein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (759 aa)
KLLA0_A07931gKLLA0A07931p. (344 aa)
HAS1ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (497 aa)
KLLA0_B01804gKLLA0B01804p. (3242 aa)
MRH4ATP-dependent RNA helicase MRH4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (584 aa)
KLLA0_B03234gKLLA0B03234p. (804 aa)
RIX1Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1. (776 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
JIP5WD repeat-containing protein JIP5. (525 aa)
KLLA0_B10934gKLLA0B10934p. (253 aa)
KLLA0_B13046gRibosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (204 aa)
KLLA0_B13563gRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
DBP9ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (594 aa)
YTM1Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (444 aa)
KLLA0_C08547gKLLA0C08547p. (515 aa)
MAK5ATP-dependent RNA helicase MAK5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (796 aa)
KLLA0_C12331gKLLA0C12331p. (662 aa)
KLLA0_C14564gKLLA0C14564p. (165 aa)
DBP3ATP-dependent RNA helicase DBP3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (504 aa)
KLLA0_C17556gKLLA0C17556p. (607 aa)
KLLA0_D00792gKLLA0D00792p. (1020 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
KLLA0_D03168gKLLA0D03168p. (505 aa)
KLLA0_D03410gKLLA0D03410p. (241 aa)
KLLA0_D05643gKLLA0D05643p. (220 aa)
KLLA0_D06941gKLLA0D06941p. (297 aa)
IPI3Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (508 aa)
KLLA0_D09735gNucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (662 aa)
KLLA0_D11792gKLLA0D11792p. (685 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
NOP16Nucleolar protein 16; Involved in the biogenesis of the 60S ribosomal subunit. (239 aa)
NOP7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (605 aa)
KLLA0_D15873gKLLA0D15873p. (431 aa)
KLLA0_D16852gKLLA0D16852p. (374 aa)
KLLA0_D19602gKLLA0D19602p. (620 aa)
GRC3Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (631 aa)
KLLA0_E00837gKLLA0E00837p. (814 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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